Clinical trials
Nicotine clinical trials
Below are recruiting nicotine clinical trials, each written for real people, not researchers. We’re tracking 143 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05413122RecruitingPhase 2/Phase 3
Smoking quit support for adults living with HIV in South Africa
This trial tests smoking-cessation interventions to help people living with HIV quit smoking or smoke less. You may be eligible if you smoke, are actively engaged in HIV treatment, and can follow the study for about a year.
Soweto, GautengAges 18 years+ - NCT05487807RecruitingPhase 1
Quit-smoking program for people with HIV in Uganda and Zambia
This study tests a tailored quit-smoking (tobacco cessation) program for people living with HIV in Uganda and Zambia. It aims to help you reduce or stop tobacco use in a way that fits your needs and local setting.
KampalaAges 18 years+ - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05665465RecruitingEarly Phase 1
Study how childhood stress may affect future smoking risk
This early study looks at how experiences from childhood may affect brain and behavior patterns related to nicotine and smoking risk. It may help researchers design better prevention strategies for people who have never smoked.
Durham, North CarolinaAges 18–21 - NCT05994209RecruitingPhase 1
Testing social media to help people stop vaping
This study tests if using social media and digital tools can help people reduce or stop vaping. It's for people who vape daily and want to quit.
St Louis, MissouriAges 15–25 - NCT06053567RecruitingPhase 3
Community smoking cessation for adults with high anxiety sensitivity
This study tests a smoking cessation program designed for adults who are very sensitive to anxiety (like feeling panicky about physical symptoms). It takes place at local YMCA centers and aims to help you quit smoking through a community-based approach.
Austin, TexasAges 18 years+ - NCT06173778RecruitingPhase 2
Semaglutide for weight management after quitting smoking
This study tests whether the drug semaglutide (often used for weight loss) can help people who quit smoking avoid gaining weight. It's for people who are overweight or have weight-related health issues and want to stop smoking.
Austin, TexasAges 18–75 - NCT06347055Recruiting
Brain stimulation study for quitting nicotine
This trial tests if a type of brain stimulation (TMS) can help people with nicotine dependence reduce cravings. It may be an option if you smoke or use e-cigarettes heavily and want to understand how your brain responds to treatment.
Columbia, MissouriAges 18–60 - NCT06461650Recruiting
Nicotine Cessation Before Breast Reconstruction
This study tests whether a program to help women with breast cancer quit using nicotine before reconstructive surgery is feasible and helpful. If you use nicotine and are scheduled for reconstruction, you may be able to join.
Gainesville, FloridaAges 18–80 - NCT06470321Recruiting
Predictors of nicotine relapse in smokers
This study looks at factors that might predict whether someone will start smoking again after quitting. It is for adults who smoke daily, want to quit, and are not on any medications.
NicosiaAges 18–60 - NCT06471387Recruiting
Study of genes linked to nicotine addiction
This study looks at your genes to understand why some people get addicted to nicotine. Your participation could help develop new treatments for quitting smoking.
NicosiaAges 18–60 - NCT06544057Recruiting
E-counseling to help quit smoking or vaping
This trial tests a real-time e-counseling program to help adults quit smoking or vaping. It is designed for those who are motivated to stop using nicotine and set a quit date.
Leicester, MidlandsAges 18–65 - NCT07007195RecruitingEarly Phase 1
Smart smell app to help you quit smoking
This study tests a smartphone app that uses your sense of smell to help you quit smoking. You'll use nicotine replacement therapy (like patches or gum) and the app to avoid relapse.
Houston, TexasAges 18 years+ - NCT06609083RecruitingPhase 1
How cannabis affects cigarette smoking
This study looks at how cannabis affects cigarette smoking habits. If you smoke every day and also use cannabis weekly, researchers want to see if cannabis changes how much you smoke.
Baltimore, MarylandAges 21 years+ - NCT06609109RecruitingPhase 1
Testing how cannabis affects e-cigarette use
This study is for daily e-cigarette users who also use cannabis at least once a week. It tests how cannabis affects vaping behavior. Researchers want to see if using cannabis changes how much or how people vape.
Baltimore, MarylandAges 21 years+ - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT06863168Recruiting
Cigarillo Education Messages for Black Young Adults
This study tests different messages to see what works best to help Black young adults avoid or cut back on cigarillo smoking. If you are between 18 and 30, identify as non-Hispanic Black, and are either open to trying cigarillos or only use them once in a while, this may be for you.
Philadelphia, PennsylvaniaAges 18–30 - NCT06931054Recruiting
Acupuncture, ear acupressure and nicotine patches for quitting smoking
This trial tests whether adding acupuncture and ear acupressure to nicotine replacement therapy helps people quit smoking. If you smoke at least 10 cigarettes a day, are 18 or older, and can read Chinese, you may be eligible.
Hong KongAges 18 years+ - NCT06948058Recruiting
E-cigarettes vs nicotine therapy for quitting smoking in obesity
This study compares e-cigarettes and nicotine replacement therapy (like patches or gum) to help people who are obese quit smoking. Participants use a study product for 8 weeks and track progress with a smartphone app.
Providence, Rhode IslandAges 21 years+ - NCT07059377RecruitingPhase 3
Semaglutide to help smokers with diabetes quit
This study tests if the diabetes drug semaglutide can help people with type 2 diabetes stop smoking more easily. Participants will get either semaglutide or a placebo to see if it improves quit rates.
Ottawa, OntarioAges 18 years+ - NCT07095205RecruitingPhase 4
Nicotine's effect on depression in brain imaging study
This trial uses a special brain scan to see how nicotine might help treat depression. It compares people with depression to healthy volunteers to understand how nicotine affects brain chemistry related to mood.
Stony Brook, New YorkAges 18–65 - NCT07111234Recruiting
Studying flavored nicotine pouches to understand user preferences
This study tests different flavors and cooling agents in oral nicotine pouches to see which ones people prefer. It may help develop safer alternatives for people who currently smoke cigarettes.
Columbus, OhioAges 21 years+ - NCT07322432RecruitingPhase 2
The CONQUER trial: quitting vaping with e-cigarette reduction
This study tests whether gradually reducing nicotine in e-cigarettes helps people who vape quit completely. It is for adults who are ready to stop and want a structured program.
New York, New YorkAges 21 years+
Hear when a new Nicotine trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for nicotine?
- Yes. Clin2 currently lists 143 recruiting nicotine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.