Clinical trials
Nicotine clinical trials
Below are recruiting nicotine clinical trials, each written for real people, not researchers. We’re tracking 143 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06106646Recruiting
Vitamin C and smoking in pregnancy: long-term lung health follow-up
This study is checking on the long-term lung health of children whose mothers took vitamin C or a placebo during pregnancy and either smoked or did not smoke. It's a follow-up to see if vitamin C might have lasting benefits for their breathing.
Indianapolis, IndianaAges 6–16 - NCT06192316Recruiting
Testing how nicotine product claims affect appeal and use
This study looks at how different claims about nicotine products affect people's interest and use. It involves both young adults who don't use tobacco and adult tobacco users, but all must not have used oral nicotine pouches recently.
Columbus, OhioAges 18–65 - NCT06239350Recruiting
Young adult tobacco and cannabis co-use study
This study tests a program to help young adults who use both nicotine and cannabis products reduce or quit nicotine use. If you are between 18 and 25, use nicotine products at least 20 days a month and cannabis at least 10 days a month, and want to quit nicotine, you may be eligible.
Charleston, South CarolinaAges 18–25 - NCT06582706RecruitingPhase 1/Phase 2
Vitamin B3 (niacin) for Alzheimer's disease
This study tests if nicotinic acid (a form of vitamin B3) can help people with mild to moderate Alzheimer's disease. It involves taking a daily pill, having a lumbar puncture, and regular check-ups to see if the vitamin improves thinking and memory.
Indianapolis, IndianaAges 60–85 - NCT06582888RecruitingEarly Phase 1
VR attention test for smoking cravings
This study tests whether a virtual reality (VR) program can measure how your brain pays attention to smoking cues. It also involves taking a medication called varenicline (Chantix) to see if it reduces cravings. You may be eligible if you are a daily smoker, have been smoking for at least 3 years, and are not ready to quit in the next month.
San Diego, CaliforniaAges 22 years+ - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT06695884Recruiting
Finding the best TMS pulse pattern to boost brain reward activity
This study tests different pulse patterns of transcranial magnetic stimulation (TMS), a noninvasive brain stimulation, to see which one best increases activity in brain reward circuits. It may help people who are dependent on nicotine.
Newark, New JerseyAges 18–55 - NCT06765291Recruiting
Help for teens to quit or reduce vaping
This program is for teens aged 14 to 19 who vape at least once a week and want to quit or cut back. It tests a behavioral support approach to help them stop using nicotine vapes.
Boston, MassachusettsAges 14–19 - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT06803706Recruiting
Gut bacteria changes during smoking quit attempt
This study looks at how quitting smoking changes your body's gut bacteria and metabolism. It is for people with a substance use disorder who want to stop smoking.
FehringAges 18 years+ - NCT06862050Recruiting
Testing a smoking cessation program for tobacco users
This trial tests a program to help people quit tobacco. It focuses on offering support to daily tobacco users living in the Augusta or Central Savannah River Area.
Augusta, GeorgiaAges 18 years+ - NCT06991712RecruitingPhase 2
NAD supplements for nerve health in glaucoma
This trial tests whether NAD precursor supplements can improve nerve health and vision in people with glaucoma. If you have glaucoma with mild to moderate vision loss, this study may help understand if these supplements could protect your optic nerve.
Wong Chuk HangAges 18 years+ - NCT07040566RecruitingPhase 2
Varenicline to help stop vaping
This trial tests whether varenicline, a medicine that reduces cravings, can help people quit using e-cigarettes that contain nicotine. You must be a daily nicotine vaper and live in Connecticut or South Carolina.
New Haven, ConnecticutAges 18 years+ - NCT07148232RecruitingPhase 4
Helping people experiencing homelessness quit smoking
This study tests an extended program to help people who are homeless and smoke at least 5 cigarettes a day quit smoking. It provides nicotine replacement therapy (like patches or gum) and support over time.
San Francisco, CaliforniaAges 18 years+ - NCT05181891RecruitingPhase 2
Trial uses enhanced cues to reduce alcohol and smoking
This Phase 2 study tests a program designed to help people cut down or stop heavy alcohol use and daily smoking at the same time. It will check your alcohol level at the start and uses urine tests during a short induction phase to confirm recent alcohol and ongoing smoking.
Spokane, WashingtonAges 18 years+ - NCT07292883RecruitingPhase 2
Accelerated TMS for smoking cessation
This trial tests whether a rapid form of brain stimulation (TMS) can help people stop smoking. It is designed for adults who are ready to quit within the next month.
Penetanguishene, OntarioAges 18 years+ - NCT07298902Recruiting
Non-invasive brain stimulation to help quit smoking
This study tests a new non-invasive brain stimulation technique to help long-term smokers quit. You'll receive a safe magnetic pulse to brain areas linked to cravings, and researchers track your progress.
Houston, TexasAges 20–60 - NCT01036581Recruiting
Brain MRI study to improve brain imaging for drug research
This study uses advanced MRI brain scans to better show how the brain responds to medicines (drug-related effects). You may also do extra safety screening and non-invasive brain stimulation for some parts of the research.
Baltimore, MarylandAges 18–80 - NCT07476144RecruitingPhase 1
Nordic Spirit pouch nicotine effects study in smokers
This study looks at how nicotine from Nordic Spirit pouches is absorbed and whether it might be habit-forming. It is for healthy adult smokers who want to test a tobacco-free nicotine pouch.
Knoxville, TennesseeAges 22–65 - NCT07568483Recruiting
Web-based smoking cessation support program
This study tests TUBSIS 2.0, a digital program designed to help you quit or cut back on smoking. You'll use it on your computer, tablet, or phone, and researchers will track how it affects your smoking habits over time.
ZurichAges 18 years+ - NCT07491627Enrolling by invitation
Nicotine's effect on gum disease treatment in smokers and non-smokers
This study looks at how smoking and nicotine affect the success of gum disease treatment. It compares results between smokers and non-smokers who have gum disease.
Liège, LiegeAges 18 years+ - NCT06924697Enrolling by invitation
Testing a diabetes drug to help men quit smoking
This study tests if a medication used for type 2 diabetes (GLP-1 receptor agonists) can also reduce smoking in men with diabetes who smoke. If you qualify, you may receive this drug or a standard diabetes pill to see if it helps you smoke less.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT03506867Enrolling by invitation
Test program to help recent smokers in Ottawa or Toronto
This trial offers a health program for people age 16+ who smoked recently and live in Ottawa or Toronto. It aims to help with quitting and follow-up over one year, especially for people facing financial hardship or housing instability.
Ottawa, OntarioAges 16 years+
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Common questions
- Are there clinical trials for nicotine?
- Yes. Clin2 currently lists 143 recruiting nicotine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.