Clinical trials
Nicotine clinical trials
Below are recruiting nicotine clinical trials, each written for real people, not researchers. We’re tracking 143 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07698470Recruiting
Brain response to smoking cues after using nicotine pouches
This study looks at how your brain reacts to smoking cues after using an oral nicotine pouch. You would need to try the pouch and avoid nicotine for 12 hours before each session.
Los Angeles, CaliforniaAges 21–55 - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT06506162Recruiting
Oral nicotine pouch study for young adult vapers
This study looks at how young adults who vape react to oral nicotine pouches (like Zyn). It tests whether these products might be appealing or lead to misuse. You must be 21–25, an exclusive vaper, and never have used nicotine pouches before.
Los Angeles, CaliforniaAges 21–25 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT06597435Recruiting
How nicotine pouch traits affect your choices
This study looks at how different features of nicotine pouches (like flavor and strength) affect people's thoughts and use. Researchers want to learn more about what people like and how they respond, which could help guide future rules or health information.
Los Angeles, CaliforniaAges 21–35 - NCT06614504RecruitingPhase 2
Nicotine control for dual e-cigarette and cigarette users
This study is testing how to help people who both smoke cigarettes and use e-cigarettes. It looks at ways to control nicotine use to help you quit or cut back.
Providence, Rhode IslandAges 21 years+ - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT06832085RecruitingPhase 4
Comparing stop-smoking medications for adult smokers in Ontario
This study compares three different stop-smoking treatments—nicotine patches, cytisine, or varenicline—to see which works best. If you want to quit or cut down in the next six months, this could help you find the right medication.
Ottawa, OntarioAges 18 years+ - NCT07250230Recruiting
Nicotine patch for pain after lung surgery in male smokers
This study tests if a high-dose nicotine patch worn before and after lung surgery can reduce pain in men who smoke but are quitting for the procedure. It aims to help manage pain during recovery.
Zhengzhou, HenanAges 18–75 - NCT07001930RecruitingPhase 1
Cannabidiol effects on stress and nicotine withdrawal
This trial tests whether a cannabis-derived compound called cannabidiol (CBD) can help people who smoke cigarettes cope with stress and withdrawal symptoms when they stop smoking. CBD is not the part of cannabis that makes you high.
Baltimore, MarylandAges 21–70 - NCT04971954Recruiting
Nicotine test to improve age-related hearing processing
This study tests whether nicotine can improve how your brain processes sounds, which can get worse with age. It’s designed for non-smokers without significant hearing or medical/medication issues.
Irvine, CaliforniaAges 18–85 - NCT06584929Recruiting
Rural smoking cessation app study
This study tests a smartphone-based program to help people who smoke at least 5 cigarettes a day quit. It focuses on adults in rural areas who want to stop smoking using their own device.
Minneapolis, MinnesotaAges 21 years+ - NCT06066996RecruitingEarly Phase 1
Study of withdrawal symptoms when people vape less
This study looks at what happens when people who vape nicotine daily try to cut back. Researchers want to understand withdrawal symptoms and find better ways to help people reduce or quit vaping.
Baltimore, MarylandAges 21–55 - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT06595459RecruitingPhase 4
Options 2 study: testing nicotine replacement or medicines to help smokers switch
This study compares different nicotine replacement options to help people who smoke switch away from cigarettes. It may be a good fit if you smoke at least 5 cigarettes a day, aren't ready to quit in the next month, and are willing to stop using other stop-smoking aids.
Madison, WisconsinAges 21 years+ - NCT06315881RecruitingPhase 2
Study of Nicotine Pouches for Cigarette or Snuff Users
This trial tests nicotine pouches (like small pouches you put in your mouth) as a way to help people who smoke cigarettes or use moist snuff. It studies how your body reacts to these pouches under controlled conditions and during daily life.
Columbus, OhioAges 21 years+ - NCT05589220Recruiting
Music and nicotine patches to reduce cravings in student smokers
This study tests whether combining music therapy with nicotine replacement (like a patch or gum) can reduce smoking cravings when students try to quit. It’s aimed at motivated students who smoke regularly and want help with quitting.
PoitiersAges 18–25 - NCT07161050Recruiting
Low nicotine and price effects on illegal cigarette buying
This study looks at how low-nicotine cigarettes and higher cigarette prices affect people's choices to buy illegal or cheaper cigarettes. It may help understand how to reduce smoking.
Roanoke, VirginiaAges 21 years+ - NCT07095140Recruiting
Nicotine and flavor effects on alcohol use study
This study tests how different nicotine levels and flavors in oral nicotine products affect alcohol drinking in young adults who use nicotine daily. It could help understand how to reduce alcohol-related harm.
Columbus, OhioAges 21–30 - NCT06851936Recruiting
Help quitting tobacco for cancer survivors and their caregivers
This study tests a program to help people with a history of cancer and their family caregivers quit using tobacco or nicotine products. You may help researchers learn what works best for supporting quitting in this group.
Gainesville, FloridaAges 18 years+ - NCT06529055Enrolling by invitation
Caffeine and nicotine pouch effects on exercise and brain function
This trial tests how caffeine and nicotine pouches affect your body during exercise, including heart function, thinking, and behavior. It looks at short bursts of high-intensity activity in healthy men who already exercise regularly.
Hattiesburg, MississippiAges 21–40 - NCT07009509Recruiting
Yes-Can! program to prevent youth vaping
This study tests a program called YES-CAN! that aims to keep middle and high school students from starting to vape nicotine. If you are a student in grades 6-12, or an adult working in a school, you may be able to join.
Aurora, ColoradoAges 9 years+ - NCT06096714RecruitingEarly Phase 1
Testing nicotine's addictive threshold in smokers
This study tests how nicotine affects the brain's reward system in people who smoke. It aims to find the level of nicotine that becomes addictive, helping guide future treatments.
West Haven, ConnecticutAges 21–59
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Common questions
- Are there clinical trials for nicotine?
- Yes. Clin2 currently lists 143 recruiting nicotine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.