Clinical trials
Nicotine clinical trials
Below are recruiting nicotine clinical trials, each written for real people, not researchers. We’re tracking 139 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT06630728RecruitingPhase 4
How Addictive Are Very Low Nicotine Little Cigars?
This study is testing whether little cigars with very low nicotine are less addictive than regular ones. Researchers want to see how smoking these affects your mood, cravings, and smoking behavior.
Columbus, OhioAges 21–75 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT06506162Recruiting
Oral nicotine pouch study for young adult vapers
This study looks at how young adults who vape react to oral nicotine pouches (like Zyn). It tests whether these products might be appealing or lead to misuse. You must be 21–25, an exclusive vaper, and never have used nicotine pouches before.
Los Angeles, CaliforniaAges 21–25 - NCT05154669RecruitingPhase 3
Coaching for quitting smoking and handling money worries
This Phase 3 study tests whether combining smoking-quit coaching with financial coaching helps people stop smoking and improve their finances. It may help if you smoke daily and also want support with money stress, while also checking that nicotine patch is safe for you.
New York, New YorkAges 18–100 - NCT04163081Recruiting
Help to quit smoking started from the emergency department
This study tests a program to help people who smoke quit, beginning when they are seen in the emergency department. It aims to see if starting nicotine-cessation support right away improves quitting over the next year.
Ottawa, OntarioAges 18 years+ - NCT06544057Recruiting
E-counseling to help quit smoking or vaping
This trial tests a real-time e-counseling program to help adults quit smoking or vaping. It is designed for those who are motivated to stop using nicotine and set a quit date.
Leicester, MidlandsAges 18–65 - NCT07604246Recruiting
How nicotine affects eye movements in e-cigarette users
This study looks at how nicotine from e-cigarettes affects eye movements and related behaviors. It involves two lab visits and may help understand nicotine's effects on the brain.
Columbus, OhioAges 21–50 - NCT07503925RecruitingPhase 4
THRIVE Study: Oral nicotine pouches and health
This study looks at how oral nicotine pouches (a type of smokeless tobacco product) affect health. If you use these pouches daily and meet a few other conditions, you may help researchers understand their public health impact.
Columbus, OhioAges 21 years+ - NCT07487818RecruitingPhase 2/Phase 3
Vagus nerve stimulation with nicotine replacement for quitting smoking
This study tests whether adding a gentle nerve stimulation device to nicotine replacement therapy (like patches or gum) can help people quit smoking more effectively. It may be a new option for those who have struggled to quit before.
Rochester, MinnesotaAges 18 years+ - NCT07322432RecruitingPhase 2
The CONQUER trial: quitting vaping with e-cigarette reduction
This study tests whether gradually reducing nicotine in e-cigarettes helps people who vape quit completely. It is for adults who are ready to stop and want a structured program.
New York, New YorkAges 21 years+ - NCT07161050Recruiting
Low nicotine and price effects on illegal cigarette buying
This study looks at how low-nicotine cigarettes and higher cigarette prices affect people's choices to buy illegal or cheaper cigarettes. It may help understand how to reduce smoking.
Roanoke, VirginiaAges 21 years+ - NCT06931054Recruiting
Acupuncture, ear acupressure and nicotine patches for quitting smoking
This trial tests whether adding acupuncture and ear acupressure to nicotine replacement therapy helps people quit smoking. If you smoke at least 10 cigarettes a day, are 18 or older, and can read Chinese, you may be eligible.
Hong KongAges 18 years+ - NCT07111234Recruiting
Studying flavored nicotine pouches to understand user preferences
This study tests different flavors and cooling agents in oral nicotine pouches to see which ones people prefer. It may help develop safer alternatives for people who currently smoke cigarettes.
Columbus, OhioAges 21 years+ - NCT07099638RecruitingPhase 2
Quitting smoking with medicine and a phone app
This study tests a combination of two medicines—varenicline (Chantix) and nicotine lozenges—plus a smartphone app to help people stop smoking. You will be asked to set a quit date within the next week or two and use the app to track your progress for about 6 months.
Oklahoma City, OklahomaAges 18 years+ - NCT07095205RecruitingPhase 4
Nicotine's effect on depression in brain imaging study
This trial uses a special brain scan to see how nicotine might help treat depression. It compares people with depression to healthy volunteers to understand how nicotine affects brain chemistry related to mood.
Stony Brook, New YorkAges 18–65 - NCT07095140Recruiting
Nicotine and flavor effects on alcohol use study
This study tests how different nicotine levels and flavors in oral nicotine products affect alcohol drinking in young adults who use nicotine daily. It could help understand how to reduce alcohol-related harm.
Columbus, OhioAges 21–30 - NCT07059377RecruitingPhase 3
Semaglutide to help smokers with diabetes quit
This study tests if the diabetes drug semaglutide can help people with type 2 diabetes stop smoking more easily. Participants will get either semaglutide or a placebo to see if it improves quit rates.
Ottawa, OntarioAges 18 years+ - NCT07009509Recruiting
Yes-Can! program to prevent youth vaping
This study tests a program called YES-CAN! that aims to keep middle and high school students from starting to vape nicotine. If you are a student in grades 6-12, or an adult working in a school, you may be able to join.
Aurora, ColoradoAges 9 years+ - NCT07007195RecruitingEarly Phase 1
Smart smell app to help you quit smoking
This study tests a smartphone app that uses your sense of smell to help you quit smoking. You'll use nicotine replacement therapy (like patches or gum) and the app to avoid relapse.
Houston, TexasAges 18 years+ - NCT07001930RecruitingPhase 1
Cannabidiol effects on stress and nicotine withdrawal
This trial tests whether a cannabis-derived compound called cannabidiol (CBD) can help people who smoke cigarettes cope with stress and withdrawal symptoms when they stop smoking. CBD is not the part of cannabis that makes you high.
Baltimore, MarylandAges 21–70 - NCT06966362RecruitingPhase 4
Help cutting back on smoking for veterans not ready to quit
This study tests a medicine called varenicline (also known as Chantix) to help veterans who aren't ready to quit smoking yet but want to cut down. The goal is to see if it helps reduce how much they smoke.
San Diego, CaliforniaAges 21 years+ - NCT06948058Recruiting
E-cigarettes vs nicotine therapy for quitting smoking in obesity
This study compares e-cigarettes and nicotine replacement therapy (like patches or gum) to help people who are obese quit smoking. Participants use a study product for 8 weeks and track progress with a smartphone app.
Providence, Rhode IslandAges 21 years+ - NCT06863168Recruiting
Cigarillo Education Messages for Black Young Adults
This study tests different messages to see what works best to help Black young adults avoid or cut back on cigarillo smoking. If you are between 18 and 30, identify as non-Hispanic Black, and are either open to trying cigarillos or only use them once in a while, this may be for you.
Philadelphia, PennsylvaniaAges 18–30
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Common questions
- Are there clinical trials for nicotine?
- Yes. Clin2 currently lists 139 recruiting nicotine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.