Clinical trials · California
Obstructive Sleep Apnea clinical trials in California
We’re tracking 22 recruiting obstructive sleep apnea studies with a site in California — including Early Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07226765RecruitingPhase 3
Weight-loss drug for sleep apnea without CPAP
This study tests a new weight-loss medication called maridebart cafraglutide against a placebo in people with moderate to severe obstructive sleep apnea who are not using a CPAP machine. The goal is to find out if weight loss can reduce symptoms like pauses in breathing during sleep.
Northridge, CaliforniaAges 18–99 - NCT07369011RecruitingPhase 3
Study of eloralintide for sleep apnea with obesity
This study tests an investigational medication called eloralintide to see if it can improve sleep apnea in people who are overweight or have obesity. You will receive either the study drug or a placebo (inactive shot), and your sleep and weight will be monitored over time.
Long Beach, CaliforniaAges 18 years+ - NCT07225686RecruitingPhase 3
Maridebart Cafraglutide for sleep apnea in adults on CPAP
This study is testing whether a new medicine, called Maridebart Cafraglutide, can help people with obstructive sleep apnea who are already using a CPAP machine. The medicine may help with weight loss and potentially improve sleep apnea. Participants will either receive the medicine or a placebo (an inactive substance), and the study lasts for several months.
Northridge, CaliforniaAges 18–99 - NCT07635563RecruitingPhase 2
Sleep Apnea Treatment with Dronabinol and Acetazolamide
This study tests a combination medication (dronabinol and acetazolamide) to treat obstructive sleep apnea in people who cannot tolerate or use CPAP machines. The goal is to find the right dose that safely reduces breathing interruptions during sleep.
Chula Vista, CaliforniaAges 18–65 - NCT07714330Recruiting
Using sound cues to treat positional sleep apnea
This study tests a device that plays sound cues to help you stay off your back while sleeping, which may reduce sleep apnea events. It's for people whose sleep apnea is worse when sleeping on their back.
Burlingame, CaliforniaAges 18–75 - NCT05237505RecruitingPhase 2
Sleep apnea plus COPD study to check heart and breathing effects
This Phase 2 study looks at the cardiovascular (heart/blood vessel) effects of having both sleep apnea and COPD. It may help doctors better understand who is at risk and how to manage these breathing problems together.
La Jolla, CaliforniaAges 40–79 - NCT05575401Recruiting
Track surgery results in kids getting tonsil removal
This trial looks at how well a specific throat surgery technique works in children who are having their tonsils removed (with or without removing adenoids). It may help improve how doctors choose and perform surgery for safer, better recovery.
Murrieta, CaliforniaAges 3–17 - NCT05804084RecruitingPhase 2
Acetazolamide for sleep apnea: sleep and brain outcomes
This study tests acetazolamide (a medicine that changes breathing chemistry) to see how it affects sleep quality and neurocognitive (brain/memory/attention) outcomes in adults with untreated moderate to severe sleep apnea. You may be eligible if you have significant sleep apnea but do not have certain safety risks or need to start standard sleep apnea treatment right away.
La Jolla, CaliforniaAges 18 years+ - NCT05953610RecruitingPhase 2
Surgery study for sleep apnea when CPAP won’t work
This Phase 2 trial tests whether a specific type of palate surgery can treat moderate-to-severe obstructive sleep apnea in people who cannot tolerate CPAP (a breathing mask). It also checks patient traits (based on sleep testing) to see who is most likely to benefit from surgery.
Westwood, Los Angeles, CaliforniaAges 21 years+ - NCT06043440RecruitingPhase 2
Oxygen therapy for sleep apnea in Down syndrome
This study tests whether oxygen therapy can help children with Down syndrome who have sleep apnea. It compares oxygen treatment to no treatment to see if it improves breathing during sleep and thinking skills.
Los Angeles, CaliforniaAges 5–18 - NCT06047496RecruitingEarly Phase 1
Time-restricted eating for sleep apnea
This study tests whether limiting your eating to a shorter daily window can improve health in people with untreated moderate to severe sleep apnea. You would eat all your meals within a set number of hours each day while tracking your progress on your smartphone.
La Jolla, CaliforniaAges 18–70 - NCT06944782Recruiting
Can mouth muscle tests help diagnose sleep apnea?
This study tests a new device that measures muscle activity in your mouth to diagnose sleep apnea—without needing to spend the night in a lab. If you've already had a sleep test showing either no sleep apnea or moderate to severe sleep apnea, and you're not using CPAP daily, you may be able to help.
San Diego, CaliforniaAges 18–80 - NCT00695214RecruitingPhase 2
Test with medicine-assisted sleep endoscopy for sleep apnea
This trial studies how well a procedure done while you sleep helps doctors understand the blockage causing obstructive sleep apnea and plan surgery. You may be helped if you’re an adult with sleep apnea who is considering surgical treatment.
Santa Monica, CaliforniaAges 18 years+ - NCT02431507Recruiting
First test of an implant device to prevent sleep apnea pauses
This trial is testing whether a new implanted device is safe and feasible for people with moderate to severe obstructive sleep apnea. It may help if you cannot tolerate CPAP (a common breathing device) and your apnea is caused by airflow blockage at the back of the tongue area.
San Francisco, CaliforniaAges 21–70 - NCT07476313Enrolling by invitation
Testing a new home sleep system for moderate to severe sleep apnea
This study tests a home sleep testing system called SleepView+ in people who have already been scheduled for an overnight sleep lab study. If you have moderate to severe obstructive sleep apnea, this device might offer a more convenient way to monitor your sleep at home.
Redwood City, CaliforniaAges 12 years+ - NCT07220525Recruiting
Sleep and heart rhythm study for people with sleep apnea device
This study looks at how turning off your sleep apnea device for short periods affects your heart rhythm, especially if you have a condition like atrial fibrillation. It may help understand the link between sleep and heart health.
San Francisco, CaliforniaAges 21 years+ - NCT05156112Recruiting
PAP breathing treatment for veterans with PTSD and substance use
This trial studies whether using a PAP breathing device (a machine that helps keep airways open during sleep) can help veterans who have PTSD and a substance use disorder while they receive residential treatment. It’s specifically for people with obstructive sleep apnea and aims to see if this treatment is safe and helpful during recovery.
San Diego, CaliforniaAges 18 years+ - NCT06722755Recruiting
CPAP for Sleep Apnea After Stroke
This study tests whether using a CPAP machine (a device that helps you breathe while sleeping) can improve recovery after a recent stroke or brain bleed. You may join if you had a stroke in the past month and are not already using CPAP.
Downey, CaliforniaAges 18 years+ - NCT06851338Recruiting
Inspire therapy study for teens with Down syndrome and sleep apnea
This study tests a device called Inspire that stimulates the airway during sleep to treat obstructive sleep apnea in teenagers with Down syndrome who cannot use a CPAP machine or had a tonsillectomy that did not work well.
Orange, CaliforniaAges 13–18 - NCT07280468RecruitingPhase 4
Personalized sleep apnea treatment for Down syndrome
This study tests if a treatment chosen based on your specific type of sleep apnea works better for people with Down syndrome. It looks for participants who have sleep apnea but are not already using a CPAP machine regularly.
San Diego, CaliforniaAges 6 years+ - NCT06566820Enrolling by invitationPhase 3
Long-term follow-up for sleep apnea study
This is a follow-up study for people with obstructive sleep apnea who have already completed two prior studies with the same medicine. The goal is to keep tracking your health and the medicine's effects over a longer time.
Santa Ana, CaliforniaAges 18 years+ - NCT07775976Enrolling by invitation
Whole-heart checkup with a wearable heart monitor
This study looks at how well a wearable heart monitor and special software can check the health of your whole heart and assess your risk of future heart problems. It may help doctors create more personalized care plans.
Pasadena, CaliforniaAges 18 years+
Obstructive Sleep Apnea trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting obstructive sleep apnea studies listed above.
- Collaborative Neuroscience Research · 2 studies
- Exalt Clinical Research · 2 studies
- Peninsula Research Associates · 2 studies
- UCLA Medical Center · 2 studies
- University of California San Diego · 2 studies
- University of California, San Francisco · 2 studies
- Valley Clinical Trials · 2 studies
- Altman Clinical and Translational Research Institute
What taking part in a obstructive sleep apnea study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Obstructive Sleep Apnea trials in other states
Common questions
- Are there obstructive sleep apnea clinical trials in California?
- Yes. We're currently tracking 22 recruiting obstructive sleep apnea studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a obstructive sleep apnea study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a obstructive sleep apnea trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New obstructive sleep apnea studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.