Clinical trials
Older Adults clinical trials
Below are recruiting older adults clinical trials, each written for real people, not researchers. We’re tracking 526 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05574127Recruiting
Brief behavioral therapy for depression in older cancer survivors
This study tests a brief behavioral activation program to help older cancer survivors with depression. It involves 10 sessions (or a shorter version) to improve mood and quality of life.
New York, New YorkAges 65 years+ - NCT05516277Recruiting
Insomnia care study for older adults with PTSD
This study tests a treatment plan for insomnia (trouble sleeping) in older adults who also have post-traumatic stress disorder (PTSD). The goal is to see whether improving sleep also supports heart and metabolic health (such as blood sugar and heart-related measures).
North Hills, CaliforniaAges 50 years+ - NCT05524597RecruitingPhase 1
Older adults write about health experiences
This study looks at how writing about your life experiences and health affects outcomes in older adults. If you’re 65 or older and meet health and safety requirements, you may be able to take part.
Los Angeles, CaliforniaAges 65 years+ - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT05465538RecruitingPhase 1/Phase 2
PET imaging study using SV2A in older adults
This early-phase study tests a PET scan tracer called SV2A in adults age 50 and older. It aims to help researchers understand how the tracer works in the brain/body, which could support future diagnostic or treatment research.
New Haven, ConnecticutAges 50 years+ - NCT05307666Enrolling by invitationPhase 4
Older adults using many medications may get simpler care
This study looks at whether older adults do better when their medication plan is simplified. You may be able to join if you’re at least 80, live in the community, and take 6 or more regular oral medications.
Edmonton, AlbertaAges 80 years+ - NCT05237687RecruitingPhase 2
Sirolimus to help prevent loss of daily function
This Phase 2 trial studies whether sirolimus can slow or prevent functional decline (more difficulty with daily activities) in older adults. You may be considered if you’re in the right age range and have no major heart, lung, liver, kidney, or recent bleeding/clotting problems.
Dallas, TexasAges 65–80 - NCT05183230Recruiting
Mobile program to help prevent suicide after hospital stay
This trial tests a phone-based (mobile) support program for middle-aged and older adults after a recent hospital stay for suicidal thoughts or an attempt. The goal is to reduce the chance of another suicidal crisis by providing structured support after discharge.
New York, New YorkAges 50–90 - NCT05124132Enrolling by invitation
Study of resilience and brain health after an earlier parent study
This trial looks at how resilience (how well people cope with stress) and brain health change over time in older adults who already joined an earlier study. You may be eligible if you participated in that “parent study.”
St Louis, MissouriAges 65 years+ - NCT05081596Recruiting
Primary care program for mood and thinking in early Alzheimer’s
This trial tests a psychosocial (talk/behavior/support) program delivered through primary care to improve thinking and depression symptoms in older adults with mild cognitive problems and early Alzheimer’s. It may help if you have early memory/thinking changes plus mild depressive symptoms and you can work with a caregiver or study partner.
White Plains, New YorkAges 60 years+ - NCT04981821Recruiting
Mobile exercise coaching for older adults with blood cancers
This study tests whether a mobile (phone-based) exercise program can help older adults with myeloid blood cancers stay active and function better while they receive outpatient cancer treatment. You may be asked to follow an exercise plan and participate in assessments during the trial.
Rochester, New YorkAges 60 years+ - NCT03894917Recruiting
Study blood and imaging features in older adults with liver cancer
This study looks at what liver cancer is like in newly diagnosed people who are older and whose cancer cannot be removed by surgery. It may help doctors better understand disease behavior and how treatments may work and affect the body.
San Antonio, TexasAges 18 years+ - NCT04521881RecruitingPhase 3
Testing an antifibrinolytic for mild head injury in older adults
This study tests whether an anti-bleeding medicine (given to reduce unwanted clot breakdown) can improve outcomes after a mild head injury in people 50 and older. It is looking for patients who arrive quickly after injury and have certain symptoms like brief loss of consciousness, confusion, or nausea.
London, LondonAges 50 years+ - NCT04405115Recruiting
Help for older adults to get better cancer aftercare
This study aims to improve “survivorship care plans,” which are follow-up instructions after chemotherapy, to help older adults feel supported after cancer treatment. You may be able to participate if you’re 65+ and recently finished chemotherapy with the goal of cure and have a plan scheduled with an oncology navigator.
Clovis, CaliforniaAges 65 years+ - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Birmingham, AlabamaAges 75 years+ - NCT04240561Recruiting
Study of hearing aid results in people with Alzheimer’s dementia
This study looks at how much hearing aid outcomes vary in older adults who have Alzheimer’s dementia or mild memory problems. It may help researchers understand what hearing aids work best and for whom.
Chicago, IllinoisAges 50–90 - NCT04078334Recruiting
Personalized exercise to prevent function decline in hospitalized older adults
This study tests whether a personalized exercise program can help older adults maintain their physical function during a hospital stay. If you are 65 or older and expect to go home after your hospital visit, this program might help you stay stronger.
Montreal, QuebecAges 65 years+ - NCT03998202Recruiting
Study of chemotherapy side effects in older colorectal cancer patients
This study looks at how chemotherapy and immunotherapy affect the body in older adults with colorectal cancer, especially early side effects. It may help researchers understand why some people lose strength and how to better predict and manage treatment toxicity.
Millville, DelawareAges 60 years+ - NCT03675724Enrolling by invitationPhase 2
Fisetin for frailty and inflammation in older adults
This trial studies whether fisetin, a supplement-like drug, can reduce frailty and inflammation in people age 70 and older. It may help improve health measures related to aging, but you must meet several safety and medication rules to join.
Rochester, MinnesotaAges 70 years+ - NCT03541135Enrolling by invitation
Study of heart health, diet, and activity in older adults
This study looks at heart health, food, and physical functioning in people age 65 and older living in Madrid. It may help researchers understand how lifestyle affects aging and cardiovascular wellbeing.
MadridAges 65–95 - NCT03035851Recruiting
Exercise program for older adults at risk of memory decline
This trial tests whether a structured aerobic (heart-pumping) exercise program can improve memory and thinking in older adults who feel memory trouble but have not been diagnosed with dementia. It focuses on people who are “at increased risk” due to common health factors like high blood pressure or diabetes.
Calgary, AlbertaAges 50–80 - NCT02290834Recruiting
Studying brain and thinking changes after chemotherapy in older breast cancer patients
This study looks at how chemotherapy may affect memory and thinking, using thinking tests and possibly brain imaging. It compares older breast cancer patients who do and do not get chemotherapy, plus a group of healthy older adults.
Boston, MassachusettsAges 60 years+ - NCT07171255Recruiting
App-based exercise program for rural adults
This trial tests if a smartphone app can help adults aged 40-85 who are not very active, live in rural parts of Kansas or Nebraska, and are at risk for health problems. The goal is to see if using the app helps them exercise more and stick with it.
Emporia, KansasAges 40–85 - NCT05468255Recruiting
Study how stopping exercise affects blood sugar and blood vessels
This study looks at what happens to blood sugar levels and blood vessel health when active adults stop exercising. It may help doctors understand how quickly these changes can happen and who may be most affected.
Norfolk, VirginiaAges Any age
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Common questions
- Are there clinical trials for older adults?
- Yes. Clin2 currently lists 526 recruiting older adults studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a older adults trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a older adults trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.