Clinical trials
Open Label clinical trials
Below are recruiting open label clinical trials, each written for real people, not researchers. We’re tracking 366 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06220487RecruitingPhase 2
New drug combo for Ph+ ALL without transplant
This trial tests a combination of three drugs—olverembatinib, a bispecific T-cell engager, and chidamide—for adults newly diagnosed with Ph+ ALL who cannot have a stem cell transplant. The goal is to see if this treatment works well without needing intensive chemotherapy.
Guangzhou, GuangdongAges 18 years+ - NCT05746897RecruitingPhase 1
First-in-human test of an anti-PVRIG drug for advanced cancers
This early-phase study tests NM1F (an anti-PVRIG antibody) in people with advanced solid tumors to see if it’s safe and whether it may work. It also includes pembrolizumab (a PD-1 “checkpoint” medicine), aiming to boost the immune system against the cancer.
Dallas, TexasAges 18 years+ - NCT06225856RecruitingPhase 1
YY201 for advanced solid tumors and blood cancers
This trial tests a new drug, YY201, that targets a protein called STAT3, which may help certain advanced solid tumors and blood cancers. It is for people who have tried standard treatments without success.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07863583Recruiting
Social connection group for older adults in subsidized housing
This study tests a program that brings older adults together in their housing community to build social connections. It may help reduce loneliness and improve well-being, and you could participate as a general resident or help lead the group.
Baltimore, MarylandAges 62 years+ - NCT07864662Recruiting
Food and vitamin D for healthy school children
This study tests if adding trout fish, cow milk with egg, and vitamin D to children's diets can improve their vitamin D levels, nutrition, and brain function. It is for healthy children aged 6-12 who go to certain schools in Pakistan.
Karachi, SindhAges 6–12 - NCT05085028RecruitingPhase 3
Lower-dose pembrolizumab for lung cancer after 6 months
This trial studies whether giving pembrolizumab less often can work just as well for advanced non-small cell lung cancer after you’ve already had 6 months of treatment and are still benefiting. It may help reduce how often you need treatment while keeping cancer control.
BournemouthAges 18 years+ - NCT06234007RecruitingPhase 2
Short radiation plus combo therapy for advanced rectal cancer
This trial tests a short course of radiation therapy followed by a combination of three drugs (fruquintinib, adebrelimab, and CAPOX chemotherapy) before surgery for people with locally advanced rectal cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
WuhanAges 18–75 - NCT07845071RecruitingPhase 3
Cebranopadol for acute pain after surgery or injury
This study tests an investigational medication called cebranopadol to see if it safely and effectively relieves acute (short-term) pain after surgery or from a muscle or bone injury. It may offer a new option for people who need relief from moderate to severe pain.
Phoenix, ArizonaAges 18–75 - NCT06467500RecruitingPhase 2
Cadonilimab plus chemo for lung cancer after immunotherapy
This trial tests a new drug called cadonilimab combined with chemotherapy for people with advanced lung cancer who have already tried and failed immunotherapy. It aims to see if this combination can help when standard immunotherapy no longer works.
YichangAges 18–75 - NCT07827014Recruiting
Protein shake study for healthy adults
This study tests a daily protein shake in two flavors to see how well people tolerate it and if it affects their well-being. You would drink it once a day for 15 days and answer some questionnaires.
Carlsbad, CaliforniaAges 21–65 - NCT07826767RecruitingPhase 1/Phase 2
Gene therapy for inherited immune disease
This trial tests a new gene therapy (SGX-001) for chronic granulomatous disease caused by a specific genetic change. The treatment tries to fix the gene in your immune cells so they can fight infections better, and the trial will follow participants for up to 15 years to make sure it's safe and effective.
UlmAges 1.5 years+ - NCT07829263Recruiting
Brain stimulation with talk therapy for cocaine use disorder
This study tests whether a non-invasive brain stimulation method (high-definition transcranial direct current stimulation, or HD-tDCS) combined with cognitive behavioral therapy (a type of talk therapy) can help people reduce cocaine use. It explores if this combination is safe and practical.
Richmond, VirginiaAges 18–65 - NCT06477991Recruiting
No surgery after immunotherapy for MSI-H colorectal cancer
This trial is studying whether some people with a specific type of advanced colorectal cancer (MSI-H/dMMR) might be able to skip surgery after immunotherapy. Doctors will use a blood test (MRD monitoring) to track the cancer, and then decide whether to keep an eye on it or operate.
Kunming, YunnanAges 18–75 - NCT07814248RecruitingPhase 1
TS-104 for advanced solid tumors
This trial tests a new drug called TS-104 for people with certain advanced solid tumors that have stopped responding to standard treatments. The drug is given alone (not with other cancer treatments) to see if it can shrink tumors or slow their growth.
Maumee, OhioAges 18 years+ - NCT07807111RecruitingPhase 1/Phase 2
Gene therapy for advanced rod-cone dystrophy
This study tests a new gene therapy for people with advanced rod-cone dystrophy, a genetic condition that causes progressive vision loss. The treatment is given as an injection into the eye, and the study aims to see if it is safe and if it can help improve or preserve vision.
GhentAges 18 years+ - NCT07807995Enrolling by invitationPhase 3
Long-term treatment for IgA nephropathy
This study tests a medication called povetacicept for long-term use in adults with IgA nephropathy, a kidney disease. If you've already completed the earlier study, this trial aims to see how well the drug works over a longer period to help keep your kidneys working longer.
Arvada, ColoradoAges 18 years+ - NCT07808827RecruitingPhase 3
New targeted drug plus chemo for large b-cell lymphoma
This trial compares a new targeted medicine (JS203) combined with chemotherapy against a standard treatment (rituximab) with chemotherapy for people whose large B-cell lymphoma has returned or not responded. The goal is to see if the new combination works better and to offer a possible new option.
Beijing, Beijing MunicipalityAges 18–75 - NCT06517004RecruitingPhase 1
Study of JWCAR201 for relapsed or refractory large B-cell lymphoma
This trial tests a new cell therapy called JWCAR201 for people with a type of lymphoma (diffuse large B-cell lymphoma) that has come back or not responded to at least two prior treatments. The goal is to see if this treatment can help when standard options have stopped working.
ShanghaiAges 18 years+ - NCT07790445RecruitingPhase 4
Adjuvant chemotherapy for bile duct cancer after surgery
This study tests whether giving chemotherapy directly into the liver (HAIC) plus an oral chemo pill (capecitabine) after surgery helps prevent bile duct cancer from coming back, compared to just the pill. It's for people who recently had their cancer completely removed.
Zhengzhou, HenanAges 18 years+ - NCT06539481RecruitingPhase 4
ILUVIEN eye implant for kids with recurrent eye inflammation
This trial tests an eye implant (ILUVIEN) in children and teens ages 6 to 17 who have a type of eye inflammation called uveitis that keeps coming back. The implant releases medicine slowly over time to control inflammation and may help reduce the need for other treatments.
BerlinAges 6–17 - NCT06176534RecruitingPhase 2
Comparing two treatments for advanced breast cancer with low hormone receptor
This trial compares two treatment options for advanced breast cancer that has low hormone receptor levels and is HER2-negative. It tests whether a combination of chemotherapy followed by maintenance therapy works better than a CDK4/6 inhibitor combined with hormone therapy. This is for people who have not had chemotherapy for their advanced disease.
Zhengzhou, HenanAges 18 years+ - NCT07773883Enrolling by invitationPhase 3
Long-term safety of solriamfetol for ADHD in children and teens
This study checks the long-term safety of the drug solriamfetol for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents who have already completed an earlier study of this medication.
Dothan, AlabamaAges 6–18 - NCT07764146RecruitingPhase 1
Study of VY1706 for early Alzheimer's disease
This study tests an experimental treatment called VY1706 for people with early Alzheimer's disease. It aims to see if the treatment is safe and how well it works, and may help slow down the disease.
Maitland, FloridaAges 30–80 - NCT07759609Recruiting
Intrauterine insemination after pregnancy loss
This study tests whether intrauterine insemination (IUI), a simple procedure where sperm is placed directly into the uterus, improves the chance of a successful pregnancy for couples who have had at least one unexplained miscarriage. It aims to help couples who are trying again within a year of their loss.
Beijing, Beijing MunicipalityAges 20–37
Hear when a new Open Label trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for open label?
- Yes. Clin2 currently lists 366 recruiting open label studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a open label trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a open label trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.