Clinical trials
Open Fracture clinical trials
Below are recruiting open fracture clinical trials, each written for real people, not researchers. We’re tracking 34 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05785182Recruiting
Scans with eye imaging for open and infected broken bones
This trial studies a special scan technique (using light from an eye camera) to look at healing in open fractures that are infected. It may help doctors better monitor how these difficult injuries respond to treatment.
Lebanon, New HampshireAges 18 years+ - NCT04299022Recruiting
Study of ViviGen bone graft for fracture healing
This study follows people who are treated with a bone graft called ViviGen to help heal fractures, delayed healing, or non-healing (“non-union”) bone problems. The goal is to check how safe it is and how well it works in real-world orthopaedic care.
Orlando, FloridaAges Any age - NCT06055712Enrolling by invitationPhase 4
Antibiotics for children with open fractures
This trial tests whether giving antibiotics can prevent infections in children with mild open fractures (grade 1 or 2) that don't need surgery. It aims to find a safer, simpler treatment plan.
St Louis, MissouriAges birth–17 years - NCT07437339RecruitingPhase 4
Irrigation volume for open fracture cleaning
This trial tests if using less fluid to clean open fractures (broken bones that poke through the skin) works just as well as using more fluid. It compares two different amounts of salt water (saline) to see which one helps prevent infections and helps bones heal better.
Falls Church, VirginiaAges 18 years+ - NCT00870064Recruiting
Study of treating small open bone breaks in children
This study looks at how to treat certain small open fractures (where a bone has broken through the skin) in children using non-surgical realignment when possible. It may help doctors confirm the best early treatment approach for less severe injuries.
Chicago, IllinoisAges 3–14 - NCT06293469Recruiting
Speeding up flap surgery for severe leg injuries
This trial tests whether performing flap surgery sooner after a severe leg injury below the knee leads to better outcomes. If you have an open fracture or dislocation that needs a flap, you may be able to join.
Sacramento, CaliforniaAges 18 years+ - NCT05421741RecruitingPhase 4
Antibiotic-coated nail to help prevent infection
This trial studies a special nail for certain broken shin bones to lower the chance of infection after surgery. If you qualify, the study team will help you receive the antibiotic-coated nail and will follow you closely for about a year.
Gainesville, FloridaAges 18 years+ - NCT05157126RecruitingPhase 4
Gentamicin antibiotic study for open tibia fractures
This trial tests whether a gentamicin antibiotic approach helps heal certain open tibia (shin bone) fractures while lowering infection risk. It focuses on adults with specific types of open, mostly closable tibia wounds treated within set time limits.
Dar es SalaamAges 18 years+ - NCT05683314Recruiting
Surgery comparison for unstable pelvic and hip socket fractures
This study looks at how to best surgically fix unstable pelvic and acetabular (hip socket) fractures, comparing different operative approaches. You might benefit if your goal is stable healing with a less invasive internal fixation method, but the study requires specific fracture types and long follow-up time.
Taichung, North DistrictAges Any age - NCT04106674Recruiting
Treating displaced shoulder fractures: non-surgery vs surgery options
This trial compares non-surgical care with two different surgical fixation methods for a displaced two-part shoulder (upper arm) fracture. It aims to see which approach leads to the best recovery and function.
Lørenskog, OsloAges 60–85 - NCT07426926Recruiting
Home light therapy for wrist fracture recovery
This study tests a special light device you can use at home to see if it helps reduce pain and improve recovery after surgery for a broken wrist (distal radius fracture). It compares the light treatment to a placebo (sham) device, so you won't know which one you get.
São PauloAges 18–65 - NCT06793644Recruiting
ICG dye imaging for open fractures and infections
This trial tests if injecting a special dye (ICG) during surgery can help doctors see blood flow and infection in open fractures or infected bone areas. The dye glows under a special camera, which may guide better treatment decisions.
Lebanon, New HampshireAges 18 years+ - NCT07775690Recruiting
Comparing two plate types for mid-upper arm fracture surgery
This study compares two surgical techniques for fixing a break in the middle of the upper arm bone. It aims to find which approach leads to better healing and recovery for patients.
Sāhīwāl, Punjab ProvinceAges 16–65 - NCT06249126Recruiting
Heel bone fusion for severe fractures
This trial tests whether fusing the joint just below the ankle (subtalar joint) during heel bone fracture repair helps people with severe fractures heal better. You may qualify if you have a specific type of broken heel bone and can return for follow-up visits for one year.
Orange, CaliforniaAges 18 years+ - NCT03713853Recruiting
Compare hip surgery methods for new pelvic bone fractures
This study compares two ways of fixing a recently broken acetabulum (the hip socket): one method keeps/repairs the socket (ORIF) and the other replaces it (THA). It aims to find which surgery approach leads to better outcomes for people who can have surgery soon after the injury.
Toronto, OntarioAges 60 years+ - NCT05766670RecruitingPhase 3
Calcium and antibiotic placed inside tibia nail for open fractures
This Phase 3 study tests whether a calcium/antibiotic “depot” released from an intramedullary nail can lower infection risk in certain open tibia fractures. It may help by delivering antibiotics right at the fracture area while the nail fixes the bone.
Los Angeles, CaliforniaAges 18 years+ - NCT05131672Recruiting
Casting vs surgery for elbow bone fractures in children
This study compares two treatments—casting or an operation—for a specific elbow fracture in children. It aims to see which approach works best for healing and recovery after a recent fracture.
Chicago, IllinoisAges 7–17 - NCT04640727Enrolling by invitation
Surgery comparison for rotated elbow fractures in children
This trial compares two surgical methods for children with a specific type of rotated, fully shifted outer elbow fracture. It aims to find which approach works better for healing and restoring elbow function.
Guangzhou, GuangdongAges 1–18 - NCT04678154RecruitingPhase 3
Antibiotic trial for severe open fractures of the leg or foot
This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.
Redwood City, CaliforniaAges 18–64 - NCT06921707Recruiting
WounDx test for healing decisions in large wounds
This trial tests a new tool called WounDx that helps doctors decide the best way to treat large wounds on arms, legs, or buttocks. It may help your wound heal better by guiding your care.
Birmingham, AlabamaAges 18–65 - NCT03765567RecruitingPhase 4
Antibiotic powder placed in certain emergency open fractures
This study tests whether putting antibiotic powder directly into an open fracture wound in the emergency room can improve care outcomes. It focuses on adults treated shortly after injury.
San Antonio, TexasAges 18–89 - NCT07400692Recruiting
Surgery vs. Non-surgery for Broken Elbow in Older Adults
This study compares two ways to treat a certain type of broken elbow in adults over 65 who are not extremely active or frail. It tests if using a metal plate to fix the bone during surgery leads to better arm function and recovery than treating the injury without surgery.
LuganoAges 65 years+ - NCT07227493Recruiting
Bioactive glass for open pilon fracture repair
This trial tests a special glass material to help heal severe ankle bone fractures. It may help people who need a bone graft after an open pilon fracture.
Columbia, MissouriAges 18 years+ - NCT05615844RecruitingPhase 3
Antibiotic beads versus negative pressure dressing for severe leg fractures
This Phase 3 study compares two ways to help heal a severe open tibia (shin bone) fracture and prevent complications like infection. If you qualify, you may receive antibiotic beads or a negative pressure wound therapy dressing after urgent wound cleaning.
Chandler, ArizonaAges 18 years+
Hear when a new Open Fracture trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for open fracture?
- Yes. Clin2 currently lists 34 recruiting open fracture studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a open fracture trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a open fracture trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.