Clinical trials
Opioid clinical trials
Below are recruiting opioid clinical trials, each written for real people, not researchers. We’re tracking 430 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06487533Recruiting
Sensing opioid withdrawal and cravings with wearable sensors
This study uses wearable sensors to track physical signs of opioid withdrawal and cravings over 14 days. It aims to better understand these symptoms in people currently taking or planning to start medication for opioid use disorder.
Center City, MinnesotaAges 18–50 - NCT05027919RecruitingPhase 2
Testing ways to predict opioid withdrawal during a taper
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
Baltimore, MarylandAges 18–65 - NCT06358040Recruiting
Opioid dispenser after back surgery trial
This trial tests a special device that gives you pain medication (opioids) after back surgery, instead of a prescription. It may help you use just the right amount of pain medicine, and you'll use your smartphone for follow-up visits.
New York, New YorkAges 18 years+ - NCT05511909RecruitingPhase 2
Buspirone study for opioid withdrawal symptoms
This Phase 2 study tests whether buspirone can help reduce symptoms during opioid detox (withdrawal). You may be able to take part if you have opioid withdrawal and are planning medically supervised detox.
Baltimore, MarylandAges 18–75 - NCT04894864RecruitingPhase 4
Opioid-free anesthesia for elective abdominal aortic aneurysm surgery
This trial studies an “opioid-free” anesthesia and pain plan during planned open surgery for an abdominal aortic aneurysm. The goal is to see whether this approach reduces surgical stress and pain compared with usual care.
Heraklion, CreteAges 40–85 - NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT07810322Recruiting
Testing a new tool to improve treatment connection for opioid use disorder
This study tests a new mobile tool called emPath that helps connect people with opioid use disorder to treatment and support. The goal is to see if using this tool improves how well people stay engaged in care.
Durham, North CarolinaAges 18 years+ - NCT07672808Recruiting
Pain relief after hip replacement without opioids
This study tests a combination of non-opioid pain medicines to reduce the need for opioids after hip replacement surgery. It aims to help patients manage pain with fewer risks of addiction and side effects.
Detroit, MichiganAges 18 years+ - NCT07639281Enrolling by invitation
Opioid Education for Ventral Hernia Repair Surgery
This study teaches patients about opioid pain medication before hernia repair surgery. It aims to help patients make informed decisions about pain management and understand safer opioid use.
Lexington, KentuckyAges 18–85 - NCT07631598Recruiting
Buprenorphine at Needle Exchange Programs to Prevent Overdoses
This study tests whether offering buprenorphine (a medication that reduces cravings and withdrawal) directly at syringe service programs (places where people get clean needles) can help people with opioid addiction stay safe and reduce overdose risk. If you use opioids and visit a syringe service program, this may be an option to explore.
Los Angeles, CaliforniaAges 18 years+ - NCT07610746Recruiting
Brain Blood Flow in Newborns Exposed to Opioids Before Birth
This study looks at how opioid exposure during pregnancy affects blood flow and brain function in newborns. Researchers will compare babies exposed to opioids in the womb with babies who were not exposed, to better understand how prenatal opioid exposure affects the developing brain.
Indianapolis, IndianaAges Up to 1 day - NCT06367218Recruiting
Opioid-free anesthesia with spontaneous breathing for VATS lung nodule surgery
This trial tests a way to do VATS lung nodule surgery without using strong painkillers (opioids) and while you keep breathing on your own. It may help you recover faster with fewer side effects.
Wuhan, HubeiAges 18–70 - NCT07510373Recruiting
Helping patients cut back on opioids after orthopedic surgery
This trial tests a program to help patients safely reduce their opioid pain relievers after leaving the hospital following orthopedic surgery. It is designed for people who are new to opioids and want to avoid long-term use.
The Bronx, New YorkAges 18 years+ - NCT07490717Enrolling by invitation
Treating PTSD and opioid use in jails
This study tests new ways to screen and treat people in jail who have both post-traumatic stress disorder (PTSD) and opioid use disorder. It aims to help participants with therapy while incarcerated and after release.
Little Rock, ArkansasAges 18 years+ - NCT07485335RecruitingPhase 4
Overdose prevention support after emergency department care
This study tests a package of support services to help people who have had an opioid overdose and are starting buprenorphine in the emergency department. The goal is to keep them safe and reduce the chance of another overdose.
Birmingham, AlabamaAges 19 years+ - NCT07486505Recruiting
Mindfulness for pain after arm or leg fracture surgery
This study tests whether brief mindfulness sessions before and after surgery help people manage pain and anxiety while recovering from a broken arm or leg, and may reduce the need for strong painkillers (opioids). It aims to see if this approach is practical and helpful for patients.
Hamilton, OntarioAges 18 years+ - NCT07389096RecruitingPhase 4
Pain relief without opioids for teens having spine surgery
This trial tests if a drug combination that avoids opioids can safely control pain during and after scoliosis surgery in teenagers. It aims to reduce opioid side effects and improve recovery.
Port SaidAges 8–18 - NCT07378189Recruiting
Opioid-free anesthesia for pancreatic surgery
This trial tests whether using a combination of non-opioid drugs during general anesthesia can reduce side effects after laparoscopic pancreatic surgery. If you are scheduled for this type of surgery and are between 18 and 80 years old, you may be able to join.
Krakow, Lesser Poland VoivodeshipAges 18–80 - NCT07348627RecruitingPhase 3
Opioid-free hip replacement study
This trial tests if using fewer opioids after hip replacement surgery can still control pain well. It uses a specific type of hip replacement called anterior total hip arthroplasty and aims to help patients recover with less reliance on strong pain medicines.
Atlanta, GeorgiaAges 18 years+ - NCT06607029Recruiting
Painkiller-free anesthesia for brain tumor surgery
This trial tests whether avoiding opioid painkillers during anesthesia for brain tumor removal can be safe and effective. It may help patients recover with fewer side effects.
BeijingAges 18–65 - NCT07231796Recruiting
Study of naldemedine for opioid-induced constipation in cancer patients
This trial tests whether naldemedine, a medication for constipation, can help cancer patients who have constipation caused by opioids. It looks at how well it works and how patients feel.
AmsterdamAges 18 years+ - NCT07218549RecruitingPhase 1
Study of psychoactive substances in people with past opioid use
This trial tests how safe certain psychoactive substances are and what effects they have in people who have used opioids in the past but are not currently dependent on them. It aims to gather information that could help future treatment options.
Houston, TexasAges 18–55 - NCT07202026Enrolling by invitation
Opioid tapering decision aid for long-term pain patients
This study tests a decision aid to help people who have been taking opioids for chronic pain decide if and how to safely reduce their dose. It aims to support patients and doctors in making careful, personalized choices.
Seattle, WashingtonAges 18 years+ - NCT07197801Recruiting
Peer support program for opioid use disorder treatment
This study tests if a peer recovery support program helps people stay in treatment for opioid use disorder. Participants who recently started medication for opioid use disorder may get extra support from a peer who has been through recovery themselves.
Danville, PennsylvaniaAges 18–89
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Common questions
- Are there clinical trials for opioid?
- Yes. Clin2 currently lists 430 recruiting opioid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.