Clinical trials
Opioid Abuse (Disorder) clinical trials
Below are recruiting opioid abuse (disorder) clinical trials, each written for real people, not researchers. We’re tracking 34 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04161066RecruitingPhase 1
Psilocybin plus buprenorphine to help opioid use disorder symptoms
This Phase 1 study tests how adding psilocybin to a standard opioid treatment (buprenorphine-naloxone) affects recovery and symptoms in people with moderate-to-severe opioid use disorder. It may help researchers understand whether this combination is safe and beneficial alongside medication for opioid withdrawal and cravings.
Madison, WisconsinAges 21–65 - NCT06718491Recruiting
A smartphone program to reduce heavy drinking for people on opioid treatment
This study tests a brief smartphone-based program to help people reduce heavy drinking while they are receiving medication for opioid use disorder (MOUD). It aims to improve both alcohol and mental health outcomes.
Columbus, OhioAges 18 years+ - NCT06405607RecruitingPhase 2
Psilocybin vs Ketamine for Alcohol Use Disorder Trial
This trial tests two psychedelic-assisted therapies, psilocybin and ketamine, to see which works better for reducing heavy drinking in people with alcohol use disorder (AUD). You'll receive either drug along with counseling, and the study monitors safety closely.
Iowa City, IowaAges 21–65 - NCT06995885Enrolling by invitation
A study to improve tracking of opioid use in the fentanyl era
This study aims to develop a better tool for recalling and tracking opioid use patterns, especially with fentanyl. It may help people who use opioids outside of medical settings to more accurately report their use.
Baltimore, MarylandAges 18–99 - NCT06484075RecruitingPhase 1/Phase 2
Suvorexant for alcohol use disorder: brain effects
This study tests whether the sleep medication suvorexant can help people with alcohol use disorder by looking at its effects on brain activity. Participants will stay in the hospital for about a month, take suvorexant or a placebo, and have brain scans.
Bethesda, MarylandAges 18–75 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT06780202RecruitingPhase 2
Steroid to reduce opioid use after foot/ankle surgery
This study tests whether a steroid medicine called Medrol Dosepak can help reduce the need for opioid painkillers after foot or ankle surgery. If you are having foot or ankle surgery at Emory and are generally healthy, you may be able to join.
Atlanta, GeorgiaAges 18–95 - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT07559500RecruitingPhase 1
Study of tirzepatide for alcohol use disorder
This trial tests if tirzepatide, a diabetes drug, affects brain chemistry linked to alcohol use. Researchers want to see if it can help people with mild-to-moderate alcohol use disorder who also have tried stimulants.
Bethesda, MarylandAges 21–65
Hear when a new Opioid Abuse (Disorder) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for opioid abuse (disorder)?
- Yes. Clin2 currently lists 34 recruiting opioid abuse (disorder) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid abuse (disorder) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid abuse (disorder) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.