Clinical trials
Opioid Use clinical trials
Below are recruiting opioid use clinical trials, each written for real people, not researchers. We’re tracking 280 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06297200Recruiting
Ultrasound treatment for complex back pain patients
This study tests a new, non-invasive ultrasound treatment for people with long-term back pain who also have opioid use disorder and anxiety. It aims to see if this gentle brain stimulation can reduce pain and improve quality of life.
Roanoke, VirginiaAges 18–65 - NCT06288711Recruiting
Video therapy for PTSD in people taking opioid medication
This trial tests a therapy called prolonged exposure (a type of talk therapy) delivered via video calls to help people with both opioid use disorder and PTSD. It aims to see if this approach can reduce PTSD symptoms.
Burlington, VermontAges 18 years+ - NCT04512144Recruiting
Mindfulness coaching for endometrial or cervical cancer patients
This study tests a mindfulness program (using an app) for people newly diagnosed with endometrial cancer surgery or cervical cancer treated with chemo-sensitizing radiation. It may help improve how you cope during treatment.
St Louis, MissouriAges 18–90 - NCT06223503Recruiting
Pain support service study for veterans after surgery
This study tests a telehealth pain support program for veterans having orthopedic surgery. It aims to help manage pain after surgery and reduce the need for long-term opioid use.
Salt Lake City, UtahAges 18 years+ - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT06136247Recruiting
Brain & thinking tests in opioid use disorder
This study tests whether brain scans and thinking tests can help understand opioid use disorder. It is for people on stable buprenorphine or methadone treatment.
Philadelphia, PennsylvaniaAges 18–60 - NCT06113211RecruitingPhase 4
Non-opioid pain control after fracture surgery
This trial tests a combination of non-opioid medications to manage pain after surgery for a broken bone, aiming to reduce or avoid the use of opioids. It may help you control pain without the risks of strong painkillers.
Detroit, MichiganAges 18–80 - NCT06100172Recruiting
Ear Stimulation After Back Surgery
This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.
Dallas, TexasAges 18–85 - NCT04724252RecruitingPhase 2/Phase 3
Gabapentin to help children use less opioid after surgery
This study tests whether gabapentin can reduce how much opioid pain medicine children need after certain major chest or heart surgeries. If it works, it may lower opioid-related side effects while still helping with postoperative pain.
Sacramento, CaliforniaAges Up to 17 years - NCT06077422Enrolling by invitationPhase 2/Phase 3
Comparing two pain blocks for heart surgery recovery
This trial compares two types of pain blocks (Exparel vs. Marcaine) given during heart surgery to see which one provides better pain relief. If you are scheduled for a heart surgery through a small or full chest incision, you may be able to join.
New Brunswick, New JerseyAges 18 years+ - NCT06051890RecruitingPhase 4
Assessing switching to long-acting buprenorphine injection in jail
This study tests whether switching from daily buprenorphine/naloxone (Suboxone) to a long-acting injectable buprenorphine (XRB) is safe and effective for men who are unsentenced and in jail for at least 4 days. It aims to see if the injection can help continue treatment without needing daily medication.
Boston, MassachusettsAges Any age - NCT05769218Recruiting
Rapid HIV prevention and opioid treatment access for people who inject
This study helps people who inject drugs start HIV prevention (PrEP) and medication for opioid use disorder (MOUD) faster. It may reduce HIV risk and improve access to treatment, while the study checks whether the “rapid access” approach works.
Boston, MassachusettsAges 18 years+ - NCT05675735Recruiting
Methadone take-home program to help people stay in treatment
This trial studies whether changing how methadone is allowed to be taken home can improve how long people stay in opioid use disorder treatment. It focuses on clinics and on adults who have already been receiving take-home methadone.
Storrs, ConnecticutAges 18 years+ - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05669534RecruitingPhase 4
HIV prevention support for people starting PrEP
This study tests how to better support HIV prevention for people who inject drugs and are newly starting PrEP (medicine to prevent HIV). It focuses on people taking medication for opioid use disorder and who have mild thinking and memory problems, to help them stay safe and adhere to prevention.
New Haven, ConnecticutAges 18 years+ - NCT05589181RecruitingPhase 3
High-dose buprenorphine start in the emergency department for fentanyl use
This Phase 3 study tests whether starting a high dose of buprenorphine in the emergency department helps people with opioid use disorder come through withdrawal more safely and effectively. It focuses on people whose urine test shows fentanyl and who are already in withdrawal when they arrive.
Newark, New JerseyAges 18 years+ - NCT05579470Recruiting
Study opioid treatment access with staff, patients, and local leaders
This study looks at how to expand opioid addiction treatment in Central Asia by gathering survey and discussion input from people with opioid dependence, people delivering treatment, and local health leadership. It may help improve how treatment programs are set up and delivered in the future.
New Haven, ConnecticutAges 18 years+ - NCT05487911Recruiting
Brain stimulation for depression
This study uses a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to treat depression. It may help reduce depressive symptoms for people who have not found relief from other treatments.
Houston, TexasAges 18–64 - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT05380531Recruiting
Personalized pain plan for planned C-section using opioid options
This trial tests a personalized approach to pain control during and after a scheduled C-section. It may help by matching pain medicine choices to each person’s needs, including the use of in-hospital opioids for relief.
Indianapolis, IndianaAges 18 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT05033028RecruitingPhase 3
Using a smartphone to support opioid addiction recovery
This Phase 3 study tests whether using smartphones can help people with opioid-use disorder stick with treatment and recover more successfully. It focuses on people starting or already in treatment using methadone or buprenorphine, with support delivered through the study app or messages.
Piscataway, New JerseyAges 18–85 - NCT04893525RecruitingPhase 2/Phase 3
Buprenorphine-naloxone microdosing versus standard dosing after ED discharge
This study compares a smaller “microdose” starting method versus the usual starting dose of buprenorphine/naloxone for people with opioid use disorder when they are discharged from the emergency department. It may help find a safer, easier way to start treatment right after an ED visit and avoid problems caused by starting too early.
Calgary, AlbertaAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85
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Common questions
- Are there clinical trials for opioid use?
- Yes. Clin2 currently lists 280 recruiting opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.