Clinical trials
Opioid clinical trials
Below are recruiting opioid clinical trials, each written for real people, not researchers. We’re tracking 430 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06458335Recruiting
Treating opioid use and loneliness
This study tests a program to help people with opioid use disorder who also feel lonely. It aims to see if treating both together can improve your health and wellbeing.
Rochester, New YorkAges 18 years+ - NCT06432465Recruiting
Brain stimulation to help prevent opioid relapse
This study uses a type of brain stimulation called tDCS (transcranial direct current stimulation) to see if it can help people who have recently started medication for opioid dependence (buprenorphine or methadone) stay on track and avoid relapse. The treatment is non-invasive and involves a mild electrical current applied to the scalp.
Providence, Rhode IslandAges 21–60 - NCT06434233RecruitingPhase 4
Opioid use after fallopian tube removal surgery
This study looks at how much opioid pain medicine people need after having their fallopian tubes removed through small incisions (laparoscopic or robotic salpingectomy). It aims to see if the usual pain medicine can be reduced to decrease opioid use.
Baltimore, MarylandAges 18 years+ - NCT06415994Enrolling by invitation
Placental imaging and outcomes in opioid use disorder in pregnancy
This study looks at how the placenta and baby's development may be affected when a mother takes buprenorphine or methadone for opioid use disorder during pregnancy. It aims to find better ways to monitor health and improve outcomes for both mothers and babies.
Indianapolis, IndianaAges 18–100 - NCT06387290RecruitingPhase 3
Mindfulness and pain management for chronic pain on opioids
This study tests whether adding mindfulness training to standard pain management visits can help people with chronic pain who are taking long-term opioids. It aims to improve pain relief and reduce opioid-related risks.
La Jolla, CaliforniaAges 18 years+ - NCT06355778Recruiting
Brain and Opioid Use Study
This study uses brain scans to understand how adversity affects opioid use and recovery. It compares people with opioid use disorder on buprenorphine, people taking buprenorphine for chronic pain, and healthy volunteers.
Ann Arbor, MichiganAges 18–55 - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Aurora, ColoradoAges 12–17 - NCT06345872Recruiting
Better sleep to help reduce opioid use for chronic pain
This study tests a sleep improvement program to help people with chronic widespread pain reduce or stop their opioid pain medication. If you want to cut back on opioids and have trouble sleeping, this treatment might be a good fit.
Tampa, FloridaAges 18 years+ - NCT06323824RecruitingPhase 4
Methadone vs. buprenorphine for opioid use disorder treatment
This study compares two medications, methadone and buprenorphine, to see which helps people stay in treatment for opioid use disorder. You may be eligible if you are starting a new treatment episode.
Oakland, CaliforniaAges 18–99 - NCT06311838Recruiting
Preventing opioid use among homeless youth
This study tests a program to help homeless youth build social connections and find stable housing to prevent opioid use. It will be conducted by Ohio State University.
Columbus, OhioAges 14–24 - NCT06316830RecruitingPhase 2/Phase 3
Finding the best buprenorphine dose for opioid use disorder
This trial tests different doses of buprenorphine to find the safest and most effective one for treating opioid use disorder and preventing overdose. It is for people who have used fentanyl and are starting or continuing buprenorphine treatment.
Providence, Rhode IslandAges 18 years+ - NCT06292078Recruiting
School program to prevent opioid misuse and exclusion
This trial tests a school-wide program called ISLA that aims to reduce opioid misuse and keep students in school. It will involve all staff and 7th graders at participating middle schools in Oregon.
Capitola, CaliforniaAges 8–15 - NCT06275191Enrolling by invitation
Testing non-opioid pain relief after tooth extraction
This trial tests whether alternative pain treatments can replace opioid painkillers after wisdom tooth or other tooth removal in teens and young adults. It aims to find safer ways to manage dental pain without relying on opioids.
Lexington, KentuckyAges 12–25 - NCT06207162Recruiting
Brain scans and methadone treatment for opioid recovery
This study uses MRI scans over time to track brain changes in people with opioid use disorder who recently started methadone treatment. You can help researchers understand recovery patterns if you are early in your methadone journey and can commit to repeated visits.
New Haven, ConnecticutAges 18–50 - NCT06218706Recruiting
Focused ultrasound for severe opioid addiction
This trial uses focused ultrasound (sound waves aimed at a specific part of the brain) to help people who have severe opioid addiction that hasn't gotten better with other treatments. It may help reduce cravings and support recovery.
Morgantown, West VirginiaAges 22–60 - NCT06201676RecruitingPhase 4
Low-dose short-term ketorolac to cut opioid use after bone surgery
This study tests whether giving a low dose of a non-steroidal anti-inflammatory drug (NSAID) called ketorolac for a short time after orthopedic surgery can reduce the need for strong painkillers like opioids. It is for people who have broken bones that need surgery with metal plates, screws, or rods.
Boston, MassachusettsAges 18–70 - NCT06160284RecruitingPhase 1
Psilocybin for brain healing in opioid recovery
This study tests whether psilocybin, a psychedelic substance, can help change brain connections in people recovering from opioid use disorder. It involves brain scans and careful medical monitoring to explore new treatment options.
New Haven, ConnecticutAges 25–55 - NCT06133933Enrolling by invitation
Shoulder replacement and pain medication study
This study looks at how your pain tolerance before a total shoulder replacement might relate to how much pain medication you need after surgery. The goal is to help doctors better manage pain medication after surgery.
Camden, New JerseyAges 18 years+ - NCT05711056Recruiting
Telehealth help to start and link treatment for opioid use disorder
This program offers telehealth support to help you start opioid use disorder treatment and get connected to ongoing care, using toxicology/medical specialists. It may help if you’re in a stable, sober condition and not already on similar treatment.
Atlanta, GeorgiaAges 18 years+ - NCT06104280Recruiting
How opioid addiction meds affect sleep and eyes
This study tests how three common medications for opioid use disorder (methadone, buprenorphine, and naltrexone) affect eye function, sleep, and daily body rhythms. It may help find ways to improve treatment for opioid addiction.
Birmingham, AlabamaAges 18–80 - NCT06067737RecruitingPhase 2
Psilocybin and buprenorphine for opioid use disorder
This study tests whether adding psilocybin (a psychedelic medicine) to buprenorphine (a medication for opioid use disorder) can help people stop using opioids and stay in recovery. It is for people who have already been on buprenorphine but are still using other opioids.
Baltimore, MarylandAges 21–70 - NCT06063902Enrolling by invitation
Long-term opioid therapy for chronic pain
This study looks at the risks and benefits of long-term use of opioids (strong painkillers) for chronic pain that is not caused by cancer. It aims to help doctors and patients make better decisions about pain management.
UppsalaAges 18 years+ - NCT06021548Recruiting
Opioid addiction markers study
This study looks at physical, psychological, and social factors that may be linked to opioid addiction. It aims to better understand addiction to help improve future treatments.
BronAges 18 years+
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Common questions
- Are there clinical trials for opioid?
- Yes. Clin2 currently lists 430 recruiting opioid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.