Clinical trials
Oral Cavity clinical trials
Below are recruiting oral cavity clinical trials, each written for real people, not researchers. We’re tracking 82 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06097468RecruitingPhase 1/Phase 2
Nisin for mouth cancer: a treatment trial
This study tests whether a natural substance called nisin, applied to mouth cancer, can help the body fight cancer cells. It is for people with a specific type of mouth cancer who are already scheduled for surgery.
San Francisco, CaliforniaAges 18 years+ - NCT05757817Recruiting
New flap surgery for mouth or throat cancer reconstruction
This trial studies whether a new surgical reconstruction method can improve outcomes for people with oral cavity or oropharyngeal squamous cell carcinoma (a type of head and neck cancer). The goal is to rebuild the area using a tissue flap while reducing problems where the tissue is taken from.
MontpellierAges 18 years+ - NCT04265430RecruitingPhase 4
MRI scans to predict normal-tissue side effects after treatment
This trial uses repeated MRI scans to better predict which patients may develop painful jaw and mouth tissue problems after radiation and/or certain bone or blood-vessel medicines. It may help clinicians spot problems earlier and tailor follow-up care.
Houston, TexasAges 18 years+ - NCT05865028RecruitingPhase 2
Test drug APG-157 for abnormal mouth tissue
This Phase 2 trial studies whether APG-157 can safely improve abnormal cells in the mouth (dysplasia) or early cancer-like changes (carcinoma in situ). You may be eligible if you have a visible, biopsy-proven lesion and can take oral medication while meeting blood and health requirements.
Miami, FloridaAges 18 years+ - NCT07063212RecruitingPhase 2
Sacituzumab govitecan plus cetuximab for head and neck cancer
This trial tests a combination of two drugs—sacituzumab govitecan and cetuximab—for people with advanced head and neck cancer that has gotten worse after immunotherapy. The goal is to see if this new treatment can shrink or slow the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT07343596Recruiting
Immunotherapy before surgery for oral cavity cancer
This study tests if giving immunotherapy before surgery helps treat oral cavity cancer. Researchers will look for markers in your biopsy that predict how well the treatment works.
Madison, WisconsinAges 18 years+ - NCT06448026RecruitingPhase 2
Cemiplimab and cetuximab before surgery for mouth or throat cancer
This trial tests whether combining two targeted drugs (cemiplimab and cetuximab) before surgery can help people with recurrent mouth or throat cancer that has come back after initial treatment. It aims to see if this approach makes surgery more effective.
Houston, TexasAges 18 years+ - NCT05791149Recruiting
Saliva test to help diagnose oral cavity cancer
This study looks for changes in saliva (epigenetic biomarkers) that may help doctors diagnose squamous cell carcinoma in the mouth. You may be asked for saliva samples and usual clinical checks to see whether the test can help with diagnosis, especially before surgery.
Amiens, PicardieAges 18 years+ - NCT05603650Recruiting
Mouthwash study for healthy bacteria in your mouth and gut
This study tests how a mouthrinse changes the helpful bacteria in your mouth and stomach/gut. You may need several visits and phone follow-ups to see how your microbiome shifts over time.
Irvine, CaliforniaAges 18 years+ - NCT04870762RecruitingTeam says not enrollingPhase 2
3D-printed tongue stents during head and neck radiation
This Phase 2 study tests whether customized 3D-printed stents can be used safely during head and neck radiotherapy. If you’re having radiation (with or without chemotherapy), the stent may help make treatment easier and more precise, potentially improving the experience and outcomes.
Phoenix, ArizonaAges 18 years+ - NCT05429099Recruiting
Planning study for jaw reconstruction surgery
This study helps teams plan surgery for people who need part of the lower jaw removed and rebuilt using special tissue flaps. It mainly looks at whether having specific pre-surgery CT images is possible and useful for reconstruction planning.
Vancouver, British ColumbiaAges 18 years+ - NCT06714760Recruiting
Flap surgery for mouth reconstruction
This trial tests a new surgical flap (using tissue from the scalp) to repair defects in the mouth after cancer surgery. It may be an option for patients with certain jawbone defects that haven't been operated on before in a specific area.
Bologna, Emilia-RomagnaAges 18 years+ - NCT05774483Recruiting
Check nodes in early mouth cancer using a biopsy or planned neck surgery
This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.
Mumbai, MaharashtraAges 18–80 - NCT06682494Recruiting
Oral Cancer Awareness for African Americans
This study aims to raise awareness about oral cancer in the African American community. It will help researchers understand how to better communicate about prevention and early detection.
Richmond, VirginiaAges 18 years+ - NCT07180901Recruiting
Optimizing care for head and neck cancer surgery patients
This trial uses a computer system to send reminders and tracking alerts to doctors and patients, aiming to improve care and outcomes after surgery for head and neck cancer. It may help you stay on track with your treatment plan.
Montreal, QuebecAges 18 years+ - NCT04809324Recruiting
Testing how best to check surgical margins in oral cancer
This trial compares two ways of checking whether all oral cancer tissue was removed during surgery by looking at the tissue edges. It may help surgeons choose the safest approach to reduce the chance of cancer coming back.
Mumbai, MaharashtraAges 18–100 - NCT05740033Recruiting
Closing the radial forearm donor site after mouth surgery
This study looks at how best to close the skin area on the forearm after surgeons take tissue to rebuild part of the mouth. If you need a radial forearm tissue reconstruction, you may be asked about outcomes afterward using English questionnaires.
Vancouver, British ColumbiaAges 18 years+ - NCT06381505Recruiting
Retractor study for mouth and throat cancer surgery
This trial tests a new tool, called a retractor, that helps doctors see and reach tumors in the mouth, throat, or voice box during surgery. It's for people with suspected or confirmed cancer in these areas who are having a scope exam at Dartmouth Hitchcock Medical Center.
Lebanon, New HampshireAges 18 years+ - NCT07343271Recruiting
Comparing CT and MRI scans for mouth and throat cancer
This trial compares two types of scans—dual-energy CT and MRI—to see which is better at evaluating squamous cell cancers of the mouth or throat. It is for patients who have already had both scans as part of their care.
StrasbourgAges 18 years+ - NCT06987253Recruiting
Test of OROXID® mouth rinse after oral surgery
This trial tests if a special mouth rinse, OROXID®, helps heal and prevent infection after a tooth extraction or root-tip surgery. It may be an option for people who are generally healthy and need this type of oral surgery.
Muljava, Municipality of Ivančna GoricaAges 18 years+ - NCT01269190Recruiting
Imaging mouth lesions during surgery to see them more clearly
This study uses a special dye and camera imaging while you have surgery or a biopsy to remove a mouth lesion. The goal is to better visualize the lesion during the operation, which may help doctors guide care more accurately.
Houston, TexasAges 18 years+ - NCT05911750Recruiting
HPV study in men with Crohn’s or ulcerative colitis
This study looks at how common human papillomavirus (HPV) is in men with Crohn’s disease or ulcerative colitis and what it may mean for health. You would answer questions and provide biology samples so researchers can understand the link, if any, between HPV and bowel disease.
BarcelonaAges 18–79 - NCT07717307Recruiting
Comparing two neck surgeries for oral cancer spread
This trial tests whether a smaller neck surgery works as well as a larger one for people with oral cancer that has spread to one lymph node. The goal is to see if less extensive surgery can reduce side effects while still controlling the cancer.
Kolhāpur, MaharashtraAges 21–75 - NCT04191460RecruitingPhase 2
Fluorescence-guided surgery for oral cancer
This Phase 2 trial tests a special light-tracking medicine (cRGD-ZW800-1) to help surgeons see oral cancer during surgery. The goal is to improve how well the tumor is found and removed while keeping side effects manageable.
Rotterdam, South HollandAges 18 years+
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Common questions
- Are there clinical trials for oral cavity?
- Yes. Clin2 currently lists 82 recruiting oral cavity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral cavity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral cavity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.