Orientation clinical trials

Brain stimulation for better mobility in vision loss

This study tests whether a safe, noninvasive brain stimulation technique (called tDCS) can help people with vision loss from retinitis pigmentosa, rod-cone dystrophy, or advanced glaucoma move around more easily and safely. Participants will do walking and orientation tasks while receiving the stimulation.

Writing program for preschoolers with sensory issues

This trial tests a task-based writing program designed to help preschoolers with sensory integration dysfunction improve their writing skills. It may benefit children who have trouble processing sensory information.

Robot hand and electrical stimulation for hand function after stroke

This test combines a soft robotic hand and electrical stimulation to help improve hand movement in people recovering from a stroke. It may benefit stroke survivors who have some ability to extend their fingers and are in the early months of recovery.

Mindfulness vs CBT for chronic pain relief

This study compares two non-drug treatments—mindfulness training and cognitive-behavioral therapy—to see which helps adults with chronic pain better. Both aim to reduce pain and improve quality of life.

Task training for multiple sclerosis patients

This trial tests a task-oriented training program to help improve hand and finger movement in people with multiple sclerosis.

Religious vs. standard hypnosis for anxiety and depression

This study compares two types of hypnosis (one that includes Islamic themes and one that follows a standard approach) to see which works better for anxiety and depression. It is designed for Muslim adults who are feeling stressed but do not have a formal mental health diagnosis.

Testing a 3D clock for Alzheimer's time orientation

This study tests a 3D tool (like a special clock) to help people with Alzheimer's keep track of time. You may be eligible if you have mild to moderate Alzheimer's and trouble with time orientation.

Combination therapy and radiation for EGFR-mutant lung cancer after resistance

This trial tests whether adding radiation therapy to a drug combination can help people with a specific type of lung cancer that has stopped responding to standard first-line pills. It's for patients whose cancer has a certain gene change (EGFR) and has spread to other parts of the body.

Task-based therapy for children with coordination difficulties

This study tests whether task-oriented exercises can improve coordination and daily skills in children aged 4 to 12 with developmental coordination disorder (a condition that makes motor tasks like writing or catching harder). The goal is to help them move more easily and feel more confident in everyday activities.

Bevel direction during dialysis fistula puncture

This study looks at which way the needle bevel should face when starting dialysis through a new fistula. It might help reduce pain or damage to the fistula.

Exercise therapy program for cancer patients in treatment

This study is testing a care program that helps cancer patients add exercise to their treatment. If you're currently on chemo, immunotherapy, or radiation and have side effects like fatigue (or just want guidance on exercise), you may be able to join.

Different therapy models for premature babies based on the ICF biopsychosocial model

This trial compares different therapy approaches for premature babies. It aims to help with their development using the ICF biopsychosocial model, which looks at health from many angles.

Emotional and orientation support to prevent delirium after surgery

This study tests whether extra emotional help and re-orienting (helping you know where you are and what’s happening) can lower the risk of confusion called postoperative delirium after surgery. It is designed for older adults having certain types of non-heart, non-brain surgery.

Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

Robot-assisted exercises for recovery after stroke

This trial tests a rehabilitation program that uses a walking robot (exoskeleton) to help people who have had a stroke on the right side of the brain and have trouble leaning or moving to one side. The goal is to improve balance and movement during recovery.

Religious beliefs and menopause: what women experience

This study looks at how religious beliefs and attitudes are connected to the menopause experience in women. It may help healthcare providers offer more caring and respectful support to women during this stage of life.

Heart Pump Device to Help After Heart Surgery Complications

This trial tests a new heart-assist device designed to help patients whose hearts are too weak to pump blood on their own after heart surgery. The device is placed through a catheter (thin tube) and aims to improve blood flow and survival in people who don't respond to standard medications.

Healthy cooking to prevent dementia and diabetes

This study tests whether learning to cook healthy meals can help prevent dementia and diabetes. You'll be asked to follow a cooking program and use your smartphone to track progress.

Group treatment to help Veterans after a recent suicidal crisis

This trial studies a “recovery-oriented” group therapy for Veterans who had a suicide attempt or started planning within the last year. It aims to help reduce risk and improve coping and recovery after a post-acute suicidal episode.

More affordable adult hearing care for eligible Alabama residents

This study aims to improve access and affordability of hearing healthcare for adults who have mild to moderate hearing loss. If you live in parts of South or West Central Alabama and meet the age and health requirements, your care may be coordinated through the program being tested.

Using health and movement data to diagnose sacroiliac pain

This study looks at medical records and physical/neurological exam findings to help diagnose sacroiliac joint dysfunction, a common source of chronic low back or buttock pain. It may help your care team better sort out what’s causing your pain and choose the right next steps.

Group therapy for joint pain in breast cancer survivors

This study tests two supportive group programs—one using mindfulness skills, the other providing supportive talk therapy—to help breast cancer survivors manage joint pain caused by hormone-blocking pills. If you have ongoing joint pain and are taking an aromatase inhibitor, you may be able to join a free, video-based group.

High-intensity exercise for inherited high cholesterol

This trial tests whether a program of high-intensity interval training can help people with familial hypercholesterolemia (an inherited condition that causes very high cholesterol). It aims to see if exercise can improve cholesterol levels and heart health.

Balance training after ACL surgery

This study compares two types of physical therapy exercises to see which works better for reducing pain, improving movement, balance, and daily function in men who have had ACL surgery. It may help you recover more fully after your knee surgery.