Clinical trials
Ototoxic Hearing Loss clinical trials
Below are recruiting ototoxic hearing loss clinical trials, each written for real people, not researchers. We’re tracking 21 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06729632Recruiting
Cooling device to protect ears from noise damage
This trial tests a non-invasive device that cools the ears to prevent hearing loss from loud noise. It is for adults aged 18-55 with normal hearing who are at risk for noise-induced hearing loss, such as firefighters.
Miami, FloridaAges 18–55 - NCT04501081Recruiting
Studying how inherited hearing loss changes over time
This study follows people and families with autosomal dominant inherited hearing loss to better understand how it progresses. It may help researchers learn what to expect over time and guide future treatment planning.
Bethesda, MarylandAges 3–99 - NCT06722170Recruiting
Gene therapy study for hearing loss caused by OTOF gene mutation
This trial tests a gene therapy called EH002 for people with severe or profound hearing loss due to changes in the OTOF gene. The treatment aims to help the ear hear better by replacing the faulty gene.
Zhengzhou, HenanAges 6 months+ - NCT07364747RecruitingPhase 2
Does acetylcysteine protect hearing during cisplatin chemo?
This trial tests if taking N-acetylcysteine (NAC) can help prevent hearing loss caused by high-dose cisplatin chemotherapy. If you're getting cisplatin and are between 18 and 70, you may be able to join.
Bangkok, BangkoknoiAges 18–70 - NCT06551857Recruiting
How cancer treatments affect hearing and thinking
This study looks at how common cancer treatments (certain chemotherapies and radiation to the head and neck) affect hearing in noisy places, thinking skills, and quality of life related to hearing. It aims to understand and possibly reduce these side effects.
Turku, Southwest FinlandAges 18–75 - NCT06885411Recruiting
Hearing loss from metal-on-metal hip implants
This study looks at whether metal-on-metal hip replacements can affect hearing. It aims to understand if there is a link between these implants and hearing loss.
DelftAges Any age - NCT05129748RecruitingPhase 2
Prevent hearing damage during cisplatin chemotherapy
This Phase 2 trial tests whether sodium thiosulfate and mannitol can reduce hearing damage (ototoxicity) in adults receiving cisplatin chemotherapy. It may help protect hearing while you get cancer treatment.
Toronto, OntarioAges 18 years+ - NCT07637981RecruitingPhase 2
Safety Study of DX243 for Hearing Loss in Noise
This study tests a new medicine (DX243) to see if it is safe and well-tolerated in people with hearing difficulties, especially trouble hearing speech in noisy environments. The goal is to understand how the body processes this medicine and whether it might help improve hearing.
Liège, LiègeAges 18–75 - NCT07646119Recruiting
Understanding Hidden Hearing Loss in Older Adults
This study investigates 'hidden hearing loss'—a condition where people have normal standard hearing test results but still struggle to hear in difficult situations. Researchers want to understand this problem better in adults over 60 to potentially improve diagnosis and treatment.
Shanghai, Shanghai MunicipalityAges 60 years+ - NCT04915183RecruitingPhase 2
Atorvastatin to help prevent cisplatin-related hearing loss
This Phase 2 trial tests whether a cholesterol medicine called atorvastatin can protect hearing in people with head and neck cancer receiving cisplatin plus radiation. If it works, it may reduce the chance or severity of treatment-related hearing damage.
Atlanta, GeorgiaAges 18–100 - NCT06521190RecruitingPhase 2
Testing ACOU085 to prevent hearing loss from cisplatin chemotherapy
This trial tests a new drug called ACOU085 to prevent hearing loss in men with testicular cancer who are receiving cisplatin chemotherapy. If you meet the hearing and health criteria, you may be able to join and help see if this drug can protect your hearing.
Tübingen, Baden-WurttembergAges 18–45 - NCT05936034Recruiting
Hearing aid vs no hearing aid during platinum chemotherapy
This study compares how patients’ quality of life changes when people who have hearing loss from platinum chemotherapy use a hearing aid versus not using one. It may help understand whether hearing aids improve daily life during treatment.
Vandœuvre-lès-NancyAges 18 years+ - NCT05946577Recruiting
Links tinnitus and hearing changes after head and neck cancer treatment
This study looks at how tinnitus (ringing in the ears) and hearing problems may develop after radiotherapy alone or with certain chemotherapy for high-risk head and neck cancer. The goal is to better understand who is more likely to experience these side effects.
ParisAges 18 years+ - NCT07389213Recruiting
Can brain stimulation and hearing aids slow memory loss in older adults with hearing loss?
This trial tests whether a non-invasive brain stimulation technique (rTMS) combined with hearing aids can help slow down thinking and memory decline in older adults who have age-related hearing loss.
Guangzhou, GuangdongAges 50–85 - NCT07288580RecruitingPhase 1/Phase 2
Gene therapy for children with inherited deafness
This trial tests an injection called EHT102 for children who have severe or profound hearing loss due to mutations in the Otoferlin gene. The goal is to see if the treatment can restore or improve hearing.
Shanghai, Shanghai MunicipalityAges 1–17 - NCT03914378Recruiting
Study how radiation and cisplatin affect hearing in head and neck cancer
This study looks at how radiotherapy, and possibly cisplatin chemotherapy, affect hearing in people treated for head and neck cancer. It may help doctors better predict hearing side effects and plan hearing monitoring or prevention.
ManchesterAges 18 years+ - NCT05312983Recruiting
Testing new hearing tests to better diagnose age-related hearing loss
This study is developing a set of hearing tests to more precisely identify age-related hearing loss. It may help you (or the study team) better understand what type of hearing problem you have and how to guide next steps.
ParisAges 18 years+ - NCT06340633RecruitingPhase 2
Testing SPI-1005 with cochlear implant surgery
This trial tests an oral medication, SPI-1005, given to adults receiving a cochlear implant to see if it improves hearing outcomes. It may help people with moderate to profound hearing loss who are scheduled for implant surgery.
Iowa City, IowaAges 18 years+ - NCT06844071Recruiting
Safety of Sentio bone conduction implant in teens
This study tests the safety and performance of the Sentio bone conduction implant (a device that helps you hear by sending sound through the skull) in teenagers aged 12 to 17. It may be an option if you have certain types of hearing loss that cannot be helped by regular hearing aids.
Atlanta, GeorgiaAges 12–18 - NCT07218913RecruitingPhase 1
Testing a drug to reduce ear damage from chemo in testicular cancer
This trial tests whether adding Pedmark (sodium thiosulfate) to cisplatin chemotherapy can protect hearing in men with stage II or III testicular germ cell tumors. It aims to reduce the risk of drug-related ear damage while still treating the cancer.
Duarte, CaliforniaAges 18 years+ - NCT06355102Enrolling by invitation
Study of tinnitus after sudden hearing loss using brain scans
This study uses brain imaging (fMRI) and blood tests to understand why some people with sudden hearing loss develop tinnitus (ringing in the ears) while others do not. It may help researchers find better ways to prevent or treat tinnitus.
Nanjing, JiangsuAges 18–65
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Common questions
- Are there clinical trials for ototoxic hearing loss?
- Yes. Clin2 currently lists 21 recruiting ototoxic hearing loss studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ototoxic hearing loss trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ototoxic hearing loss trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.