Clinical trials
Pain After Surgery clinical trials
Below are recruiting pain after surgery clinical trials, each written for real people, not researchers. We’re tracking 419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02352116Recruiting
Pain treatment plan after outpatient surgery for young children
This study tests a pain-management plan right after surgery for children ages 1–6 who go home the same day. It aims to see whether the plan improves comfort after anesthesia without requiring longer hospital recovery.
New York, New YorkAges 1–6 - NCT07452770Recruiting
Stress ball use during cataract surgery for pain and fear
This study tests whether squeezing a stress ball during cataract surgery can help reduce pain, fear, and increase satisfaction. It is for people having their first cataract surgery who are awake and able to squeeze a ball.
Istanbul, IstanbulAges 18 years+ - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Stanford, CaliforniaAges 18–75 - NCT06465992Enrolling by invitationPhase 4
Liposomal bupivacaine with dexamethasone for foot surgery pain relief
This trial tests whether adding dexamethasone to liposomal bupivacaine in a nerve block provides better pain relief after foot or ankle surgery. If you're having foot or ankle surgery and are willing to answer a few surveys, you may be able to join.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07578545Recruiting
Pain management after minimally invasive chest surgery
This study tests whether combining a specific type of chest surgery (using small cameras) with numbing injections around nerves reduces pain and the need for strong pain medications after surgery. Researchers want to see if this approach helps patients recover better with less opioid use.
Antalya, MuratpaşaAges 18–75 - NCT07674836Recruiting
Comparing two nerve blocks for chronic pain after breast surgery
This study tests two types of nerve blocks (SPSIP and ESP blocks) to see which one works better for long-term pain after a single-sided breast surgery like mastectomy. It aims to find a safer, more effective way to manage chronic pain after surgery.
İzmit, KocaeliAges 18–65 - NCT07186426RecruitingPhase 3
Testing HSK21542 for pain after hip replacement surgery
This trial tests a new pain medicine called HSK21542 for people who have hip replacement surgery under general anesthesia. It aims to see if the drug can safely reduce moderate to severe pain after surgery.
Beijing, Beijing MunicipalityAges 18–74 - NCT07269106RecruitingPhase 4
Testing anrikefon for pain relief after eye surgery
This trial tests a new painkiller called anrikefon for people having eye surgery under general anesthesia. It aims to see if it's safe and effective for controlling pain after the procedure.
Guangzhou, GuangdongAges 18–70 - NCT07104825Recruiting
Nerve block for pain after weight loss surgery
This trial tests if a nerve block can help control pain after gastric bypass or sleeve gastrectomy. The goal is to reduce the need for strong pain medicines and improve recovery.
Evanston, IllinoisAges 18–90 - NCT07002541Recruiting
Nerve block comparison for breast surgery pain
This study tests two different nerve-block methods (PECS-II and ESP) to see which better reduces painkiller use during breast surgery. A special monitor guides how much pain medicine you need. The goal is to help you recover with less opioid side effects.
IstanbulAges 18–80 - NCT07221786Recruiting
Opioid reduction before spine surgery
This trial tests whether slowly reducing opioid pain medications before spine surgery can lead to a better recovery afterward. It is for adults already taking daily opioids who have major spine surgery planned at least a month away.
Philadephia, PennsylvaniaAges 18 years+ - NCT07233538Recruiting
Numbing injection before nose surgery for better pain relief
This study tests a numbing injection in the cheek area before septorhinoplasty to see if it improves pain control and reduces the need for strong IV pain medicine. It may help you have a smoother recovery with less discomfort.
Ankara, YenimahalleAges 18–65 - NCT07331441Recruiting
Nerve block for pain relief after major upper abdominal surgery
This trial tests a nerve block given near the ribs to see if it reduces pain after surgeries like gastric, liver, gallbladder, or pancreatic surgery. It may help you need less pain medicine after the operation.
ShanghaiAges 18–85 - NCT07525986RecruitingPhase 4
Pain control after laparoscopic colon surgery using a button-press system
This trial tests a new pain medication (anrikefon) that patients can control themselves by pressing a button after laparoscopic colon surgery. The goal is to see if it works better or safer than standard pain relief, especially for patients whose nerve blocks alone don't fully control pain.
Beijing, Beijing MunicipalityAges 18–75 - NCT06671002RecruitingPhase 4
Pain medicine safety study for kids having surgery
This study compares different pain medicines to see which works best and is safest for children after surgery for tonsil removal, gallbladder removal, or knee arthroscopy. It aims to help find the most effective and least risky pain control option.
Los Angeles, CaliforniaAges 12–20 - NCT07429916RecruitingEarly Phase 1
Ketamine for shoulder pain after weight loss surgery
This trial tests if a single dose of ketamine, given during surgery, can reduce common shoulder pain after laparoscopic gastric sleeve surgery. If you are having this weight-loss procedure and meet the weight and health criteria, this study may help improve your recovery.
IrbidAges 18–60 - NCT05196503RecruitingPhase 3
PRF gel in spine surgery to reduce nerve pain after herniation
This Phase 3 study tests whether applying a healing material called platelet-rich fibrin (PRF) around the nerve during disc herniation surgery can reduce leftover nerve pain afterward. If you qualify, your team will compare pain intensity between standard care and PRF during the operation.
Strasbourg, Bas-RhinAges 18 years+ - NCT07640646Recruiting
Heart Surgery and Long-Term Pain: A Patient Survey
This study asks patients who had heart surgery in the past year about any ongoing pain or discomfort in the surgical area. The goal is to understand how common long-term pain is after heart surgery and how it affects daily life.
Leuven, Vlaams BrabantAges 18 years+ - NCT07541040Recruiting
Nerve Blocks for Breast Surgery Pain Relief
This trial tests two different nerve-block techniques to reduce pain after breast surgery. The study compares a serratus block with an ESP block—both are injections of numbing medication near nerves—to see which works better for managing pain without heavy opioid use.
İzmit, KocaeliAges 18–65 - NCT07491146RecruitingPhase 2
Study of HSK55718 for pain after abdominal surgery
This trial tests a new medicine, HSK55718, to see if it safely reduces pain after planned abdominal surgery. It is for adults who have moderate or severe pain after surgery and are otherwise in good health.
Changsha, HunanAges 18 years+ - NCT06869967Recruiting
Pain Control After Ear Surgery (Mastoidectomy)
This study tests a pain-blocking injection to reduce pain after a specific type of ear surgery (mastoidectomy). It may help you feel less pain after your operation.
IstanbulAges 18 years+ - NCT05795478Recruiting
Oxycodone plus pregabalin for long-term pain after spinal surgery
This trial studies whether taking oxycodone together with pregabalin (both pain medicines) can reduce chronic pain that can linger after spinal surgery. If you qualify, you may be asked to rate your pain and complete questionnaires during recovery.
BeijingAges 18 years+ - NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT07034300RecruitingPhase 4
Comparing lidocaine with and without dexmedetomidine for arm surgery
This trial tests whether adding dexmedetomidine to lidocaine works better for numbing the arm during surgery. Patients get numbing medicine through a special IV in the arm while the surgery is happening.
Lahore, Punjab ProvinceAges 18–60
Hear when a new Pain After Surgery trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pain after surgery?
- Yes. Clin2 currently lists 419 recruiting pain after surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain after surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain after surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.