Clinical trials
Pain and Anxiety clinical trials
Below are recruiting pain and anxiety clinical trials, each written for real people, not researchers. We’re tracking 150 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07344467Recruiting
Melatonin vs. Pregabalin for pain and anxiety after spine surgery
This trial compares two medications—melatonin and pregabalin—to see which works better at reducing pain and anxiety after spine surgery. It aims to find a safer, effective option for recovery.
Tanta, El-GharbiaAges 21–60 - NCT06001502Recruiting
Virtual reality for pain and anxiety after heart bypass surgery
This trial tests whether using virtual reality (VR) goggles after heart bypass surgery can help reduce pain and anxiety. If you are having a planned CABG and have no major vision, hearing, or other health issues, you may be eligible.
Amsterdam, North HollandAges 18 years+ - NCT07307703Recruiting
TENS for pain and anxiety after gallbladder surgery
This trial tests whether TENS, a mild electrical therapy, can reduce pain and anxiety after gallbladder removal. If you are having planned gallbladder surgery and are in good health, you may be able to participate.
Niğde, AdanaAges 18 years+ - NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT06913270Recruiting
Virtual reality for pain during burn dressing changes
This study tests whether using virtual reality (VR) during dressing changes can help reduce pain and anxiety for adults with burn injuries. If you have moderate to severe pain during dressing changes, this approach might offer extra comfort without extra medication.
CairoAges 18–65 - NCT07767344Recruiting
Video education for gallbladder surgery recovery
This trial tests whether watching an educational video before gallbladder removal surgery can improve trust in your doctor, reduce pain, and lower anxiety. It may help you feel more prepared and calm before and after your procedure.
Sanliurfa, EyyübiyeAges 18–65 - NCT05540106Recruiting
Art therapy to reduce pain and anxiety in the ER waiting room
This trial studies whether guided art therapy can lower the pain and anxiety you feel while waiting to be seen in the emergency department. It may help you feel more calm and comfortable during the waiting time.
Stony Brook, New YorkAges 18 years+ - NCT06917300Recruiting
Virtual reality to reduce pain and anxiety before spine surgery
This trial tests if using virtual reality before surgery can help reduce pain and anxiety in people having elective spine surgery. If you're scheduled for spine surgery and speak Polish, you may be able to participate.
Lodz, Łódź VoivodeshipAges 25–70 - NCT07338292Recruiting
Virtual reality for pain and anxiety in urology procedures
This study tests if using virtual reality can reduce pain and anxiety during outpatient urology procedures like circumcision, prostate biopsy, or flexible cystoscopy. If you are having one of these procedures for the first time, you may be able to participate.
PadovaAges 18–99 - NCT07362589Enrolling by invitation
Does pain education before knee or hip replacement help?
This study tests whether a special education session before knee or hip replacement surgery can help reduce anxiety, pain, and the need for pain medicine after surgery. If you are scheduled for joint replacement and can take part in a short learning session, you may be eligible.
Istanbul, KayişdağiAges 18 years+ - NCT07234396Recruiting
Animated video for kids having elbow pins removed
This trial tests whether watching a short animated video before getting metal pins removed from a broken elbow can help reduce pain and anxiety in children. It compares the video to the usual care, which is just talking to the child.
Karachi, SindhAges 4–12 - NCT05505188Recruiting
Predicting long-term pain after head and neck radiotherapy
This study looks for ways to predict and improve pain you may have months after radiotherapy for first head and neck cancer. It may help doctors better anticipate pain and support patients during recovery.
CaenAges 18 years+ - NCT05141591Recruiting
Anxiety before ENT surgery and opioid use after surgery
This trial looks at whether people’s anxiety before ear, nose, and throat (ENT) surgery affects how much pain medicine (opioids) they need after surgery. It may help doctors better plan pain control based on anxiety level and possibly gender-related patterns.
Vienna, State of ViennaAges 18 years+ - NCT07122843Recruiting
VR and AI meditation for hospital pain relief
This study tests if a virtual reality (VR) meditation program can help reduce pain in hospitalized patients. If you have at least moderate pain (4 out of 10 or higher) and can speak English or Spanish, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT06436378Recruiting
Music Therapy for Chronic Pain Patients
This study tests whether listening to music can help people with chronic pain feel better. It is for people who are already being treated at the pain clinic at CHU de Québec-Université Laval and can attend a few sessions at the university.
Québec, QuebecAges 18 years+ - NCT06978166Recruiting
Digital therapy for chronic pain and mood
This study tests a smartphone app that gives you personalized tips and exercises to help manage chronic pain along with depression or anxiety. It is designed for adults ages 45 and older and aims to see if these digital check-ins can improve how you feel day to day.
St Louis, MissouriAges 45 years+ - NCT07288047Recruiting
Virtual reality for pain during early abortion
This study tests if using a virtual reality headset during a first trimester procedural abortion can help reduce pain and anxiety. You may be eligible if you are planning to have an abortion at Planned Parenthood of Western Pennsylvania and meet the criteria below.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06785389Recruiting
How fear before surgery affects pain and recovery
This study looks at how feeling scared or anxious before surgery might affect your pain and recovery afterward. It aims to help improve care for future patients.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT06407518Recruiting
Preoperative medicine for pain relief in colorectal cancer patients with sleep or anxiety issues
This trial tests whether taking a medicine called midazolam before surgery can help with pain after surgery in people with colorectal cancer who have trouble sleeping or feel anxious. You would receive the medicine as a drink before your operation.
Guangzhou, GuangdongAges 18–60 - NCT05895383RecruitingPhase 4
Nitrous oxide breathing during vasectomy: a feasibility study
This study looks at whether self-adjusting nitrous oxide (a calming gas) with oxygen can be safely and comfortably used during a vasectomy, and how people experience it. You may be offered the gas to see how it fits into care during the procedure.
Boston, MassachusettsAges 21–85 - NCT06970431Recruiting
Anxiety and pain relief during C-section
This trial tests a way to reduce anxiety and pain before and during a C-section. It may help pregnant women feel calmer and more comfortable.
Wuhan, HubeiAges 18–40 - NCT07689461Recruiting
Virtual reality for pain after hip replacement
This trial tests if using virtual reality can help reduce pain after hip replacement surgery. It may be a good option if you are having a hip replacement and have moderate to severe pain.
MalatyaAges 18–99 - NCT07005973Recruiting
Mindfulness app for surgery anxiety
This trial tests if a mobile mindfulness program can help reduce anxiety before surgery. If you feel anxious about an upcoming non-emergency surgery under general anesthesia, you may be able to join.
Hong KongAges 18 years+ - NCT07437469Recruiting
Binaural beats for pain and anxiety after surgery
This trial tests if listening to binaural beats (a type of sound therapy) after hip or knee replacement surgery can help reduce pain and anxiety. You would receive the sound therapy through headphones while in the recovery room.
Miami, FloridaAges 18–99
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Common questions
- Are there clinical trials for pain and anxiety?
- Yes. Clin2 currently lists 150 recruiting pain and anxiety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain and anxiety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain and anxiety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.