Clinical trials
Pain Management After Surgery clinical trials
Below are recruiting pain management after surgery clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06559215RecruitingPhase 2
Pain management with Exparel after knee surgery in teens
This trial is testing a long-acting numbing medicine called Exparel to see how well it controls pain after a specific knee surgery (MPFL reconstruction) in teens and young adults. It may help reduce the need for strong painkillers after the operation.
Frisco, TexasAges 13–21 - NCT07532590Recruiting
Pancreas Plus: smartphone app for pancreatic cancer monitoring
This study tests a smartphone app designed to help people with pancreatic cancer track their health and receive educational information about their condition. The app asks simple questions regularly and provides supportive content to help you stay informed and connected to your care team.
Pavia, PaviaAges 18 years+ - NCT07480278Recruiting
Pain relief after back surgery: two injections compared
This trial tests two different injection methods to see which one provides better pain relief after lower back surgery. If you are having a microdiscectomy, this study may help determine the best way to manage your post-operative pain.
Bursa, NilüferAges 18–65 - NCT07388745Recruiting
Comparing two pain blocks for heart bypass surgery
This study compares two different nerve-block injections (one near the spine, one under the shoulder blade) to see which provides better pain relief after heart bypass surgery. If you are scheduled for a planned bypass and are in reasonably good health, you might be able to join.
KütahyaAges 45–85 - NCT07571252RecruitingPhase 4
Pain Relief Before Jaw Surgery: A Study
This study tests whether taking pain medicine before jaw surgery (orthognathic surgery) helps reduce pain after the procedure. If you're having jaw surgery, this trial may help doctors understand the best way to manage your pain.
San JuanAges 21–65 - NCT06968065Recruiting
Pain control after minimally invasive heart surgery: nerve block vs wound injection
This study compares two ways to manage pain after minimally invasive heart surgery: a nerve block injection near the ribs or injecting numbing medicine into the wound. The goal is to find which method works better for reducing pain and your need for painkillers.
IstanbulAges 18–75 - NCT07280195Enrolling by invitationPhase 4
Comparing pain relief after shoulder replacement
This study compares two ways to manage pain after shoulder replacement surgery: a long-acting numbing medicine (ZYNRELEF) versus a temporary nerve block catheter. It aims to see which provides better pain control and recovery.
St Louis, MissouriAges 18 years+ - NCT07364864Recruiting
Opioid-free anesthesia for pancreas surgery
This study tests whether avoiding opioids (strong painkillers) during surgery for pancreas or duodenum cancer can lead to a smoother recovery. If you are having a large incision in your belly for this surgery, you might be able to use only regional anesthesia and other non-opioid medicines.
Krakow, Lesser Poland VoivodeshipAges 18–80 - NCT07185594RecruitingPhase 2/Phase 3
Study of a new pain drug after abdominal surgery
This trial tests a new medication called HRS-2129 for managing pain after abdominal surgery. It is for adults who will have moderate to severe pain after their operation, and aims to see if the drug can help control that pain safely.
Zhengzhou, HenanAges 18 years+ - NCT06996561RecruitingPhase 2/Phase 3
How your genes affect pain relief after surgery
This study looks at how your genes might affect pain relief from a medication called nalbuphine after abdominal or pelvic surgery. It aims to personalize pain management based on your genetic makeup.
Karachi, SindhAges 18–70 - NCT07864896RecruitingPhase 3
Study of a new pain medicine after knee replacement surgery
This trial tests a new oral pain medicine called suzetrigine for people who have a knee replacement. It aims to see if it helps control pain after surgery better or with fewer side effects than usual care.
New York, New YorkAges 18–80 - NCT07226700RecruitingPhase 3
Suzetrigine for pain after hip replacement surgery
This study tests an investigational pain medicine called suzetrigine to see how well it controls pain after total hip replacement surgery. It is for adults 18–80 who are having a first-time hip replacement and can receive spinal anesthesia.
New York, New YorkAges 18–80 - NCT07413055RecruitingPhase 3
Comparing two doses of dexamethasone for dental implant pain
This study tests whether a higher dose of dexamethasone (8 mg) works better than a lower dose (4 mg) for reducing pain after getting a single dental implant. It may help find the best way to manage discomfort after surgery.
MuscatAges 21–80 - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT07076069RecruitingPhase 4
Rotator cuff repair pain study: fewer narcotics
This trial tests a mix of pain medicines (multimodal regimen) to see if it reduces the need for strong narcotics after arthroscopic rotator cuff repair. If you have a torn rotator cuff that hasn't healed with other treatments and you are scheduled for surgery, you may be able to join.
The Bronx, New YorkAges 18 years+ - NCT07739303Recruiting
Nerve block comparison for shoulder surgery
This study compares two types of numbing injections (nerve blocks) given before shoulder surgery to see which one provides better pain relief while keeping your diaphragm (the muscle that helps you breathe) working well.
Yenimahalle, AnkaraAges 18–65 - NCT07442188Recruiting
Comparing two numbing blocks for hernia surgery pain
This trial compares two types of numbing injections (nerve blocks) given before hernia surgery to see which one works better for pain after the operation. The blocks target muscles around the belly area to help you feel less pain and recover more comfortably.
Ankara, Yenimahalle\AnkaraAges 18–65 - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT06545409Recruiting
Nerve block for pain relief in robotic thymus surgery
This trial tests a nerve block to reduce pain after robotic thymus surgery. It may help patients with thymus growths or cysts have less pain and use fewer painkillers after their operation.
RomeAges 18 years+ - NCT04371445RecruitingPhase 4
Dextenza drops after eye surgery to reduce post-op pain
This trial studies whether Dextenza (a steroid pain-relief eye insert) can improve comfort after a specific type of retina surgery (pars plana vitrectomy). It looks at people getting surgery for conditions like macular hole, epiretinal membrane, or vitreomacular traction.
Cleveland, OhioAges 18 years+ - NCT07218133Recruiting
Ear Stimulation to Reduce Pain After Spine Surgery
This trial tests whether a gentle electrical stimulation delivered through the ear can reduce inflammation and pain after major spinal fusion surgery. If you are having a long spinal fusion, you might be able to join.
St Louis, MissouriAges 18 years+ - NCT07859397Recruiting
Pain relief options for knee ligament surgery
This study compares two nerve-block approaches to see which provides better pain relief after knee ligament reconstruction surgery. If you are having this surgery, joining could help manage your pain more effectively.
AnkaraAges 18–65 - NCT07761936RecruitingPhase 3
Safinamide for Parkinson's disease pain
This study tests whether safinamide, an add-on medication for Parkinson's disease, can reduce chronic pain in people who also experience motor fluctuations (times when symptoms return between doses). It aims to see if this treatment can improve pain and quality of life.
Verona, VenetoAges 18 years+ - NCT07141108Recruiting
Using a digital tool to track chronic pain and improve quality of life
This trial tests a digital tool that helps you track your pain and activity level. The goal is to see if using the tool can improve your quality of life. You would use a smartphone or tablet app and share updates with your primary care team.
Malmö, Skåne CountyAges 18 years+
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Common questions
- Are there clinical trials for pain management after surgery?
- Yes. Clin2 currently lists 186 recruiting pain management after surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain management after surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain management after surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.