Clinical trials · Massachusetts
Pain clinical trials in Massachusetts
We’re tracking 92 recruiting pain studies with a site in Massachusetts — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT03858205Recruiting
Low-dose radiation to relieve pain from bone tumors
This trial studies whether low-dose radiation can reduce pain from a specific bone lesion caused by multiple myeloma. It may help people whose main problem is painful bone metastasis, with targeted treatment to the painful spot.
Boston, MassachusettsAges 18 years+ - NCT03705598Recruiting
Tai chi for older adults with chronic pain
This study tests whether practicing Tai Chi can reduce pain and improve balance in older adults who have chronic pain in multiple areas. Tai Chi is a gentle form of exercise that involves slow movements and breathing, and it may help you feel better and reduce your risk of falling.
Boston, MassachusettsAges 65 years+ - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Boston, MassachusettsAges 18 years+ - NCT01788410Recruiting
MRI-guided freezing treatment for neck, head, and spine pain
This trial studies an MRI-guided procedure that “freezes” targeted nerves or joints to reduce pain in the head, neck, or spine. It may help if your pain comes from a joint problem or a compressed/damaged nerve and you can safely have MRI scans before and after the treatment.
Boston, MassachusettsAges 18 years+ - NCT07728695RecruitingPhase 1/Phase 2
Cannabis product for gynecologic pain study
This trial tests a new cannabis-based product to see if it helps with gynecologic pain (like endometriosis). It looks at how the product works and whether it is safe and effective.
Belmont, MassachusettsAges 21 years+ - NCT07674901Recruiting
Knee sleeve vs. no sleeve for chronic knee pain in older adults
This study tests whether wearing a fabric knee sleeve every day for up to 5 years helps reduce knee pain in people aged 50–64. It compares sleeve use to not using a sleeve to see if it makes a difference over time.
Springfield, MassachusettsAges 50–64 - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Waltham, MassachusettsAges 18 years+ - NCT07405645Recruiting
Focused Ultrasound for Cancer Pain in the Head or Neck
This trial tests a non-invasive focused ultrasound treatment aimed at a specific brain area to reduce severe cancer-related pain in the head, neck, or upper chest. It may help if your pain hasn't responded to standard medications.
Boston, MassachusettsAges 18–85 - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Burlington, MassachusettsAges 18 years+ - NCT07336537Recruiting
Testing talk-based data collection software for chronic pain
This study tests easy-to-use talk-based software to collect health information from people with chronic pain. It may help researchers learn if tools like these are helpful for managing pain at home or in a lab.
Cambridge, MassachusettsAges 18 years+ - NCT07270276Recruiting
Dry needling for shoulder muscle pain
This study tests if dry needling (a therapy that uses thin needles to release muscle knots) can help with shoulder muscle pain. It uses special tests to measure how the treatment affects your muscles and pain.
Boston, MassachusettsAges 18–80 - NCT07268118RecruitingPhase 2
Pain relief for cervical ripening balloon in labor
This study tests if using lidocaine gel on the cervix before placing a ripening balloon can reduce pain for pregnant women at full term. It may help women who want this balloon to start labor feel more comfortable.
Boston, MassachusettsAges 18 years+ - NCT07209436Recruiting
Comparing two nerve blocks for implant-based breast reconstruction pain
This trial compares two types of nerve blocks (pectoral and paravertebral) to see which one provides better pain relief and physical recovery after immediate implant-based breast reconstruction. It is for adults having this surgery for the first time, either for treatment or prevention.
Boston, MassachusettsAges 18 years+ - NCT07023523Recruiting
Controlling brain activity for chronic pain
This study tests if people with fibromyalgia can learn to control their own brain activity using real-time feedback from an MRI machine to reduce pain. It is designed to help those with long-term chronic pain find new ways to manage it.
Boston, MassachusettsAges 18–65 - NCT06240260Recruiting
TENS unit for pain relief during IUD insertion
This study tests whether a small device called a TENS unit can reduce pain during IUD insertion. The TENS unit sends gentle electrical pulses through pads on your skin to help block pain signals, and you'll be part of a group that uses it during the procedure.
Boston, MassachusettsAges 12–50 - NCT06976138Recruiting
Using Light or ions to Improve Sleep and Pain After Knee Surgery
This study tests whether a special bright light or negative ion therapy can help older adults sleep better and have less pain after knee replacement surgery. It's for people with knee arthritis who already have trouble sleeping and are scheduled for one knee replacement.
Chestnut Hill, MassachusettsAges 60 years+ - NCT06969105Recruiting
Music for comfort during labor and delivery
This study tests whether listening to music during labor can help reduce pain and anxiety. Researchers will compare outcomes for laboring women who listen to music versus those who do not.
Boston, MassachusettsAges 18 years+ - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT06812247Recruiting
Therapy dog visits for hospitalized trauma patients
This study looks at whether visits from therapy dogs can help people who are in the hospital after a traumatic injury feel better. You must be able to talk to the research team and not be afraid of dogs.
Boston, MassachusettsAges 18 years+ - NCT06799052Recruiting
Cervical preparation for same-day abortion procedure
This study compares two methods of preparing the cervix (the opening to the uterus) on the same day as a dilation and evacuation (D&E) procedure for abortion at 16 to 18 weeks of pregnancy. The goal is to see which preparation approach works best and is safest.
Boston, MassachusettsAges 16 years+ - NCT06757075RecruitingPhase 4
Managing pain after children's dental surgery
This study tests different ways to manage pain in young children after dental surgery done under general anesthesia. It aims to find the best method to keep children comfortable and reduce discomfort.
Brighton, MassachusettsAges 4–6 - NCT06723158Recruiting
Virtual reality glasses for oral surgery with sedation
This trial tests if wearing virtual reality (VR) glasses during oral surgery helps patients relax while under IV sedation. It may be a good option if you need sedation for a tooth extraction or other mouth procedure.
Boston, MassachusettsAges 16–65 - NCT06721819RecruitingPhase 3
Sleep and brain training before heart surgery to prevent delirium
This study tests whether a combination of sleep therapy, brain games, and light exercise before heart surgery can help prevent confusion or disorientation (delirium) after the operation. Participants will be asked to use a tablet and fitness tracker daily for about an hour before their surgery.
Boston, MassachusettsAges 60 years+ - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+
Pain trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting pain studies listed above.
- Beth Israel Deaconess Medical Center · 4 studies
- Brigham and Women's Hospital · 3 studies
- Massachusetts General Hospital · 3 studies
- Tufts Medical Center · 2 studies
- Athinoula A. Martinos Center for Biomedical Imaging
- AugMend Health at MIT.nano Immersion Lab
- Berkshire Medical Center
- Boston Medical Center
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Pain trials in other states
Common questions
- Are there pain clinical trials in Massachusetts?
- Yes. We're currently tracking 92 recruiting pain studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.