Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07788027Recruiting
Comparing two root canal cleaning methods for reducing post-procedure discomfort
This study compares two different methods of delivering a cleaning solution during root canal treatment to see which one causes less pain and discomfort after the procedure. Participants will be randomly assigned to one of the two methods.
MinyaAges 18–45 - NCT07212920Recruiting
Video physiotherapy for recent knee injuries
This study tests whether a video-based physiotherapy assessment works as well as an in-person exam for people with recent knee injuries. If you have a knee injury that started 1 to 12 weeks ago and haven't been treated yet, you may be able to participate from home using your phone or computer.
AlingsåsAges 18 years+ - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT04326192Recruiting
Spinal cord stimulation to reduce stubborn back and leg pain
This trial tests whether spinal cord stimulation (a treatment where a device sends mild signals to the spinal cord) can improve persistent nerve-type back and leg pain. It is mainly for adults who are already planning to try spinal cord stimulation but have not tried it before.
Portland, OregonAges 21–70 - NCT07458360Recruiting
Front block for better recovery after hip replacement
This study tests if a special nerve block called the front block (pericapsular nerve group block) improves recovery after hip replacement surgery. You may be eligible if you are having hip replacement under spinal anesthesia and do not have certain health issues.
KonyaAges 18 years+ - NCT07783386Recruiting
Comparing nerve block volumes for breast surgery pain
This study compares different volumes of a nerve block (SPSIP) for pain relief after breast surgery. It aims to see if one volume provides better pain control with fewer side effects.
Nilufer, BursaAges 18–75 - NCT05444361Enrolling by invitation
Ultrasound freezing treatment for pain after mastectomy
This trial tests a “freezing” nerve procedure guided by ultrasound to help reduce pain after mastectomy. It aims to lessen postoperative pain by temporarily calming specific nerves involved in chest wall sensation.
Los Angeles, CaliforniaAges 18 years+ - NCT06069154Enrolling by invitation
Freezing nerves for rib fracture pain
This study tests a procedure called cryoneurolysis, which uses cold to temporarily freeze nerves near broken ribs to relieve pain. It is for adults who have 1 to 6 recently broken ribs with at least moderate pain and are already getting a nerve block injection.
La Jolla, CaliforniaAges 18 years+ - NCT07409337Recruiting
Self-acupressure for period pain and PMS
This trial tests if doing acupressure on yourself can reduce period pain and premenstrual symptoms over about six months. It might help if you have painful periods and are looking for a non-medicine option.
Niğde, MerkezAges 18–30 - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT05985772Recruiting
Surgery vs no surgery for a type of knee tear
This trial compares surgery with non-surgical treatment for a specific tear in the knee's meniscus, the posterior-medial root tear. It aims to find out which approach works better and helps you decide with your doctor.
Chicago, IllinoisAges 18 years+ - NCT07311889Enrolling by invitation
Patient satisfaction with ELIXIR MD during plastic surgery recovery
This study looks at how satisfied patients are with their recovery after plastic surgery when the ELIXIR MD device is used. It aims to understand if this device helps improve the recovery experience.
Irvine, CaliforniaAges 18 years+ - NCT07776600Recruiting
Pain coaching by text or phone for veterans
This study tests a text or phone chatbot that offers pain coaching to veterans with chronic pain. It may help you manage your pain and avoid extra clinic visits.
Augusta, GeorgiaAges 18 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT07777081Recruiting
How your brain and body recover after a wrist fracture
This study looks at how your brain and body heal after a wrist fracture. By joining, you'll help doctors understand recovery better, which could improve care for future patients.
Cambridge, CambridgeshireAges 18 years+ - NCT07776379Recruiting
Predicting recovery with BDNF blood levels in chronic low back pain
This study looks at whether a protein in your blood, called BDNF, can help predict how well you might do with chronic low back pain. By participating, you may help doctors better understand and treat this condition.
Daegu, DaeguAges 20–80 - NCT07776366Recruiting
Study of disc protein levels and disc wear
This study looks at a protein called periostin in the discs of the lower back to see if it relates to how worn down the discs are, which might help improve future treatments.
Daegu, DaeguAges 20–80 - NCT07779135Recruiting
Aromatherapy for nerve pain from breast cancer treatment
This study tests whether using essential oils can help reduce pain, tingling, or numbness in hands and feet caused by paclitaxel chemotherapy for breast cancer. If regular pain medications aren't working well, this natural approach may offer additional relief.
ColmarAges 18 years+ - NCT07778069Enrolling by invitation
Virtual reality for children having joint steroid injections
This study tests whether using virtual reality (VR) during a steroid joint injection helps children feel less pain and anxiety. If it works, it could make the procedure easier for patients from 5 to 17 years old.
Columbus, OhioAges 5–17 - NCT07542730RecruitingPhase 4
Diphenhydramine to ease discomfort during early abortion procedure
This study tests whether adding diphenhydramine (a common allergy medicine) to sedation helps patients feel more comfortable during a procedural abortion in the first trimester. Researchers want to see if it improves pain control and overall experience.
Rochester, New YorkAges 18 years+ - NCT07779551Enrolling by invitation
Pain relief after thyroid surgery: comparing two numbing drugs
This study compares two medications, bupivacaine and ropivacaine, given as a neck block before thyroid surgery to see which provides better pain relief after the operation. It may help reduce post-surgery discomfort.
Sargodha, Punjab ProvinceAges 20–40 - NCT06975072RecruitingPhase 4
Can magnesium affect nerve monitoring during back surgery?
This study tests if giving magnesium during open thoracolumbar fusion surgery (a type of back surgery) affects nerve monitoring. It might help find the right dose for patients while keeping their nerves safe.
San Francisco, CaliforniaAges 18 years+ - NCT07221617RecruitingPhase 4
Methadone for pain after heart surgery
This trial tests whether a single dose of methadone given during heart surgery can improve pain control and recovery. It may be an option for people having planned (not emergency) heart surgery.
Rochester, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.