Clinical trials
Paraplegia clinical trials
Below are recruiting paraplegia clinical trials, each written for real people, not researchers. We’re tracking 35 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06553976Recruiting
Research network for hereditary spastic paraplegia
This trial aims to build a research network and gather information from people with two genetic types of hereditary spastic paraplegia (SPG4 and SPG5A). It will help doctors better understand these conditions and improve care.
Miami, FloridaAges Any age - NCT04712812Recruiting
Study of childhood-onset hereditary spastic paraplegia
This study follows people with hereditary spastic paraplegia that started in childhood to better understand how the condition progresses over time. It may help doctors learn what to expect and how to plan care, using genetic information and family history.
Boston, MassachusettsAges Up to 30 years - NCT03981276Recruiting
Study aims to understand inherited walking stiffness disorders
This study looks at the causes and biology (“biomarkers”) of hereditary spastic paraplegias and related conditions. You may join as someone with the condition, a family member without symptoms, or a healthy person, to help researchers understand what’s happening in the nervous system.
InnsbruckAges Any age - NCT04006418Recruiting
Study of spastic paraplegia in patients and healthy controls
This study enrolls people diagnosed with spastic paraplegia and also compares them with healthy people. It helps researchers learn more about the condition and may guide future care or treatments.
FuzhouAges Any age - NCT03206190Recruiting
Study for early SPG4 symptoms in family members
This study looks at people in families with a known SPG4 gene change (a SPAST mutation) to understand early, subtle signs and the beginning of symptoms. It may help researchers find better ways to detect SPG4 earlier, before full walking problems start.
TübingenAges 18–70 - NCT06478238RecruitingEarly Phase 1
Calcium folinate for hereditary spastic paraplegia type 56
This trial tests a drug called calcium folinate (a form of vitamin B9) to see if it can help people with a rare genetic type of spastic paraplegia (SPG56). It aims to improve leg stiffness and weakness caused by a specific gene change.
Shanghai, Shanghai MunicipalityAges Any age - NCT07803276RecruitingPhase 4
Injecting botox for stiff muscles: hands or ultrasound?
This study compares two ways of giving Botox injections to reduce muscle stiffness in people with spastic paraplegia: one uses the doctor's hands to find the injection spot, and the other uses ultrasound to guide the needle. The goal is to see if ultrasound guidance improves the results.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07561359Enrolling by invitation
12-Week Home Exercise Program for Hereditary Spastic Paraplegia
This trial tests whether a guided 12-week strength and movement exercise program, done at home using your phone or computer, can improve walking ability and muscle strength in people with hereditary spastic paraplegia (a genetic condition that causes leg stiffness and weakness). The program is tailored to your current fitness level.
Porto Alegre, Rio Grande do SulAges 16–70 - NCT06742697Recruiting
Exercise program to improve walking in Hereditary Spastic Paraplegia
This study tests a combined exercise program with flexibility, strength, aerobic, and movement training to see if it helps improve walking in adults with Hereditary Spastic Paraplegia. Participants attend at least 10 supervised sessions over several weeks.
Bosisio Parini, LombardyAges 18 years+ - NCT06272279Recruiting
Spinal Stimulation for Spinal Cord Injury
This study is testing a new way to use spinal cord stimulation to help people with spinal cord injuries. The goal is to see if it can improve movement or other functions.
Winnipeg, ManitobaAges 18–65 - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT06728787Recruiting
Robot-assisted walking for hereditary spastic paraplegia
This trial tests if robot-assisted walking therapy can help people with hereditary spastic paraplegia (a condition causing progressive leg stiffness and weakness) improve their walking ability. It may be an option if you can walk indoors on your own.
Bosisio Parini, Italy/leccoAges 4–70 - NCT06572046Recruiting
Registry for hereditary spastic paraplegia (HSP)
This registry collects information from people with hereditary spastic paraplegia or spastic ataxia to help plan future treatments. It aims to better understand the condition and connect patients with potential therapies.
PisaAges Any age - NCT05354622Recruiting
Genetic testing study for inherited leg stiffness
This study looks at genes (DNA) to understand an inherited condition that causes gradually worsening leg stiffness. It may help researchers learn what causes the condition and potentially guide future care.
Boston, MassachusettsAges 1 month–30 years - NCT07798674Recruiting
Natural history study for ataxias and spastic paraplegias
This study tracks how ataxias and related movement disorders progress over time. By joining, you help researchers learn more about these conditions and prepare for future treatments.
InnsbruckAges 5 years+ - NCT07732868Enrolling by invitation
Virtual Reality Therapy for Spinal Cord Injury
This trial tests a virtual reality (VR) program that uses brain-machine interface (BMI) technology to help people with spinal cord injuries regain movement. The program may help your brain and body work together better, potentially improving your recovery.
AveiroAges 18–65 - NCT07625332RecruitingPhase 2/Phase 3
Galantamine for Metabolic Syndrome in Spinal Cord Injury
This study tests whether a medication called galantamine can help improve metabolic syndrome (a cluster of health conditions including obesity, high blood sugar, and high cholesterol) in people with chronic spinal cord injury. The goal is to see if this treatment can reduce health risks and improve overall wellness.
West Orange, New JerseyAges 21–75 - NCT07536386Recruiting
Robotic Exoskeleton Walking Aid for Spinal Cord Injury
This study tests a self-balancing robotic exoskeleton device designed to help people with spinal cord injuries stand and walk. Researchers will assess whether the device improves mobility and quality of life over nine visits to a research center.
ParisAges 18 years+ - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT07417943Recruiting
Brain stimulation to improve movement in hereditary spastic paraplegia
This study tests whether a non-invasive brain stimulation technique (called neuromodulation) can improve walking, balance, and other movements in adults with hereditary spastic paraplegia (HSP). It may be a good fit if you can walk with or without help, have stable spasticity medications, and don't have a pacemaker or epilepsy.
Lexington, KentuckyAges 18 years+ - NCT06844734Recruiting
Study of ITB treatment for hereditary spastic paraplegia
This trial tests if a treatment called ITB (intrathecal baclofen) can help reduce muscle stiffness in people with hereditary spastic paraplegia (HSP). Participants will receive the treatment and be followed over time to see how well it works.
Shanghai, Shanghai MunicipalityAges 14–70 - NCT06156813Recruiting
Turkish lower limb movement log for stroke patients
This study aims to adapt a questionnaire that measures how well stroke survivors can use their legs in daily life. It may help doctors better understand your recovery and guide your rehabilitation.
GaziantepAges 18–80 - NCT07222033Recruiting
Self-balancing exoskeleton for spinal cord injury
This trial will test a self-balancing personal exoskeleton for people with spinal cord injuries. It may help you walk again and improve your mobility.
New York, New YorkAges 18 years+ - NCT06936163Recruiting
Surgery for foot deformities in hereditary spastic paraplegia
This study looks at how well surgery works for foot problems like tight heel cords or clubfoot in people with hereditary spastic paraplegia (HSP), a condition that causes leg stiffness. It aims to see if surgery can improve walking, reduce pain, and prevent falls.
Shanghai, Shanghai MunicipalityAges 10–45
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Common questions
- Are there clinical trials for paraplegia?
- Yes. Clin2 currently lists 35 recruiting paraplegia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a paraplegia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a paraplegia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.