Clinical trials
Parkinson Disease Dementia clinical trials
Below are recruiting parkinson disease dementia clinical trials, each written for real people, not researchers. We’re tracking 315 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06088121Recruiting
TMS with cognitive training for mild Alzheimer's dementia
This study tests a combination of brain stimulation (TMS) and cognitive training to improve memory and thinking in people with mild Alzheimer's. It may help if you are already on a stable dose of a donepezil-type medication and have a confirmed Alzheimer's diagnosis.
Incheon, Bupyeong 6(yuk)-dong, Bupyeong-guAges 60–85 - NCT06084533Enrolling by invitation
Brain inflammation imaging in Parkinson's disease
This study uses a special PET scan to look for signs of brain inflammation in people with Parkinson's disease. It aims to understand how inflammation relates to Parkinson's and may help in developing new treatments.
St Louis, MissouriAges 50 years+ - NCT05962489Recruiting
Sleep-focused DBS therapy study for Parkinson’s disease
This study looks at a sleep-focused approach to brain stimulation (DBS) in people with Parkinson’s disease. You may be able to join if you’re planning or scheduled for specific DBS surgery at the University of Minnesota and have the needed brain imaging.
Minneapolis, MinnesotaAges 21 years+ - NCT05967390Enrolling by invitation
Personalized brain-mapping test using a scalp-to-brain scan
This trial looks at whether a personalized brain “map” using imaging and scalp measurements can be measured and evaluated in people who can safely attend the testing. It may help researchers better understand how brain structure relates to performance, using scan-based measurements and related procedures.
Hong KongAges 60–95 - NCT05603715RecruitingPhase 2
Pyridostigmine to help constipation in Parkinson’s
This trial tests whether pyridostigmine can improve constipation symptoms in people with Parkinson’s disease. If you have Parkinson’s and functional constipation (with infrequent bowel movements), this study may offer a new medication option and closely track your bowel function.
Burlington, VermontAges 18 years+ - NCT05568498RecruitingPhase 2
Probiotic trial for depression in Parkinson’s disease
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Vancouver, British ColumbiaAges 40–80 - NCT05357612RecruitingPhase 4
PET scan study for brain serotonin in neurodegenerative diseases
This study uses a special PET brain scan tracer to better understand serotonin receptor activity in people with certain neurodegenerative conditions, especially when they develop hallucinations or delusions. The results may help researchers improve how these brain changes are measured and tracked over time.
Nashville, TennesseeAges 50–85 - NCT04997642Recruiting
Parkinson’s patient database for memory and movement tracking
This study builds a research database of people who receive care for Parkinson’s disease, including those with mild memory problems or dementia. It aims to collect consistent information that researchers can use to better understand Parkinson’s and related thinking changes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04701177Enrolling by invitation
Smartphone-based study of brain biomarkers in memory clinic patients
This observational study follows people with (or at risk for) Alzheimer’s-related brain changes and a comparison group without them. It uses clinic visits, cognitive testing, questionnaires, and possibly a spinal fluid test to better understand brain biomarkers and how they relate to thinking and daily life.
Corfu, CorfuAges 45 years+ - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04335994Recruiting
Home sleep testing for people with memory trouble
This study looks at how well home sleep apnea testing works for people with cognitive impairment (memory/thinking problems) to help improve outcomes. You may be asked to do a home sleep test (and possibly an in-lab test) and will involve a caregiver if needed.
Toronto, OntarioAges Any age - NCT03402919Recruiting
Brain and memory study for people with thinking changes
This study looks at memory and thinking changes using questionnaires, memory testing, and brain scans. It may help researchers better understand neurodegeneration and dementia and how these problems show up over time.
Calgary, AlbertaAges 50–90 - NCT03623672Enrolling by invitation
Study for early signs of Parkinson-related brain changes
This study enrolls people with idiopathic REM sleep behavior disorder, a sleep problem that can come before Parkinson’s disease or related conditions. It aims to better understand early (“prodromal”) changes so future treatments can be targeted earlier.
Sun City, ArizonaAges 18 years+ - NCT03233646Recruiting
Retina scans in memory and nerve disorders
This study uses pictures of the back of your eye (retinal imaging) to look for differences in people with neurodegenerative diseases and compares them with people without these conditions. It may help researchers understand eye changes that could connect to brain or nerve health.
Durham, North CarolinaAges 18 years+ - NCT03174938Recruiting
BioFINDER 2 study for healthy aging and memory problems
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
ÄngelholmAges 20–100 - NCT02763683Recruiting
Study brain changes in Parkinson-related dementia
This study looks at brain features linked to dementia in people who have Parkinson disease. It may help researchers understand why dementia happens in Parkinson and how it could be detected or treated in the future.
St Louis, MissouriAges 50 years+ - NCT07138560RecruitingPhase 4
Study of IPX-203 for Parkinson's disease (BOOST-PD)
This study tests a new formulation of carbidopa-levodopa (IPX-203) to see how well it works for people with Parkinson's disease. It uses a wearable device to measure movement and aims to improve “off” time, when symptoms return between doses.
Cleveland, OhioAges 40 years+ - NCT05025254Recruiting
Online thinking tests for people with Parkinson’s disease
This study tests online “thinking” (cognitive) abilities in people with Parkinson’s disease. It may help researchers better understand how thinking changes over time and how tests can be done from home.
Montreal, QuebecAges 45–90 - NCT05741151Recruiting
Testing a nerve target in Parkinson’s disease
This trial is studying the “superior cervical ganglion” as a possible treatment approach for Parkinson’s disease. It may help people whose symptoms are truly caused by Parkinson’s, not by another condition.
RomeAges 30–80 - NCT06323278Recruiting
Thinking and memory training for Parkinson's disease
This study tests whether a thinking-and-memory training program (cognitive stimulation) can help people with Parkinson's who have mild memory or thinking problems, but not dementia. You must not have had deep brain stimulation surgery.
MilanAges 18–80 - NCT06456684Recruiting
AV133 PET scan study in early Parkinson's disease
This study uses a special PET scan to look at a protein (VMAT2) in the brain that is linked to Parkinson's disease. It helps researchers understand early changes in people with newly diagnosed Parkinson's or those at high risk of developing it.
Beijing, Beijing MunicipalityAges 30 years+ - NCT07832695Recruiting
Brain stimulation plus practice for Parkinson's disease
This study tests whether a type of brain stimulation, called repetitive transcranial magnetic stimulation (rTMS), combined with guided practice can improve movement and daily function in people with Parkinson's disease. It may help you move better and do everyday tasks more easily.
Taipei, Zhongzheng Dist.Ages 18 years+ - NCT07798271Recruiting
Optimizing deep brain stimulation for Parkinson's disease
This study is for people with Parkinson's disease who already have a deep brain stimulator (a device that sends electrical pulses to the brain) and still have motor fluctuations (times when symptoms come and go). The researchers want to see if adapting the device's settings can better control symptoms than the current standard settings.
Davis, CaliforniaAges 18 years+ - NCT07777419Recruiting
Thinking and mood after brain stimulation for Parkinson's
This study looks at how deep brain stimulation (a treatment that uses mild electrical pulses to help control movement) affects thinking and mood in people with Parkinson's disease. It is a joint study by a Swiss university hospital that uses records from usual care and tests over time.
BernAges 18–75
Hear when a new Parkinson Disease Dementia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for parkinson disease dementia?
- Yes. Clin2 currently lists 315 recruiting parkinson disease dementia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a parkinson disease dementia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a parkinson disease dementia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.