Clinical trials
pMMR/MSS Adenocarcinoma of the Colon or Rectum clinical trials
Below are recruiting pmmr/mss adenocarcinoma of the colon or rectum clinical trials, each written for real people, not researchers. We’re tracking 115 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06805045Recruiting
Image-guided surgery for rectal cancer
This trial uses special imaging to guide surgery for rectal cancer. It studies whether detailed scans taken before surgery can help doctors remove the cancer more precisely.
BolognaAges 18–80 - NCT06812728RecruitingPhase 2
Chemo and radiation before surgery for advanced rectal cancer
This trial tests giving a strong chemotherapy combination (FOLFIRINOX) followed by radiation before surgery for locally advanced rectal cancer. If you have stage 3 or high-risk stage 2 rectal cancer that has not spread, this approach may shrink the tumor and improve outcomes.
Shibīn al Kawm, MenoufiaAges 18–70 - NCT06834126RecruitingPhase 1
Papaverine with radiation for advanced rectal cancer
This trial tests if adding papaverine (a drug) to radiation therapy can help people with locally advanced rectal cancer avoid surgery and keep their rectum. It is for patients who have already had chemotherapy and want a non-surgical approach.
Duarte, CaliforniaAges 18 years+ - NCT06850090RecruitingPhase 3
Comparing two chemo drugs before radiation for rectal cancer
This trial tests if a newer chemo pill (TAS-102) works better than the standard pill (capecitabine) when given before radiation and surgery for rectal cancer. It is for people with stage II or III rectal cancer that has certain high-risk features.
Jinan, ShandongAges 18–75 - NCT06919068Recruiting
Colon camera capsule for gut bacteria in the blood
This trial tests whether a camera capsule can detect problems in the large intestine when certain gut bacteria are found in the blood. If you have one of these bacteria and are stable enough for the exam, it might help identify the source of the infection.
OdenseAges 18 years+ - NCT06958432RecruitingPhase 2/Phase 3
Short-course radiation plus chemo and immunotherapy for rectal cancer
This trial tests a treatment plan that uses a short course of radiation to the lymph nodes-sparing area, followed by chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of mid or low rectal cancer (pMMR/MSS). The goal is to see if this approach can shrink the tumor and improve outcomes without needing extensive surgery.
Guangzhou, GuangdongAges 18–75 - NCT07011576RecruitingPhase 2
Fruquintinib plus FOLFIRI for second-line metastatic colorectal cancer
This trial tests a combination of two drugs, fruquintinib and FOLFIRI chemotherapy, as a second treatment option for people with metastatic colorectal cancer. It is designed for patients who have already received one prior treatment containing oxaliplatin, fluoropyrimidine, and bevacizumab.
Denver, ColoradoAges 18 years+ - NCT07026422RecruitingPhase 2
Combination immunotherapy with chemoradiation for high-risk rectal cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy and radiation before surgery for people with a specific type of high-risk rectal cancer. The goal is to see if adding these drugs can improve treatment results.
Jinan, ShandongAges 18–75 - NCT07094204RecruitingPhase 1
A study of ASP5834 for adults with solid tumors and KRAS mutations
This trial is testing a new drug called ASP5834 for people with advanced solid tumors that have a specific change in the KRAS gene. The study will find the best dose and see if it helps shrink tumors.
Santa Monica, CaliforniaAges 18 years+ - NCT07115914Recruiting
PSMA PET scan to monitor prostate cancer after focal therapy
This trial uses a special PET scan (PSMA PET) to check if prostate cancer returns after focused treatment (focal therapy). It may help find any remaining cancer that standard scans miss.
Chicago, IllinoisAges 18 years+ - NCT07213193Recruiting
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RomaAges 18 years+ - NCT07245095RecruitingPhase 2
Pre-medication for better views during upper endoscopy
This trial tests whether taking two medicines (N-acetylcysteine and simethicone) before an upper endoscopy helps the doctor see the stomach lining more clearly. It may be an option for people having their first endoscopy, without active bleeding.
Mexicali, Estado de Baja CaliforniaAges 18–99 - NCT07283939Recruiting
Testing a tool to adjust chemo doses and reduce treatment delays
This trial tests a computer algorithm called PAGODA that helps doctors adjust chemotherapy doses for people with gastrointestinal cancers. The goal is to prevent unplanned treatment delays while keeping the treatment effective.
Fairbanks, AlaskaAges 18 years+ - NCT02107105Recruiting
Study how surgery affects life quality in rectal cancer
This trial studies how surgical treatment for rectal cancer affects patients’ quality of life and other day-to-day impacts. It may help doctors understand what to expect after surgery and how to better support patients.
Houston, TexasAges 18 years+ - NCT02292641Recruiting
MRI study for repeat pelvic colorectal cancer
This study uses a special MRI to help understand and stage colorectal cancer that has come back in the pelvis. The goal is to improve how doctors make treatment decisions after previous surgery.
OsloAges 16 years+ - NCT07467980Recruiting
Measuring oxygen in the colon during bowel surgery
This study tests a new way to measure oxygen levels inside the colon during surgery, right after the surgeon reconnects the bowel. It may help doctors see if the new connection is healing well.
Nashville, TennesseeAges 18 years+ - NCT07535112RecruitingPhase 1
Testing BAY 3771249 for Advanced Colorectal Cancer With KRAS Mutation
This early-stage study tests a new drug called BAY 3771249 in people with advanced colorectal cancer that has a specific genetic change (KRAS G12D mutation). Researchers want to learn if it's safe and whether it helps shrink tumors.
Phoenix, ArizonaAges 18 years+ - NCT07589205RecruitingPhase 1
Testing IBI3028 for Advanced Solid Tumors
This early-stage trial tests a new drug called IBI3028 in people with advanced cancers that cannot be removed by surgery or have spread. The study aims to find the right dose and understand how the drug works in your body.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06993402Enrolling by invitation
Düsseldorf ESD Study
This study is testing the use of ESD, a procedure to remove abnormal tissue from your digestive tract using a thin, flexible scope. It may be an option if you need this procedure in your esophagus, stomach, duodenum, colon, or rectum.
Düsseldorf, North Rhine-WestphaliaAges 18 years+
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Common questions
- Are there clinical trials for pmmr/mss adenocarcinoma of the colon or rectum?
- Yes. Clin2 currently lists 115 recruiting pmmr/mss adenocarcinoma of the colon or rectum studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.