Clinical trials
pMMR/MSS Adenocarcinoma of the Colon or Rectum clinical trials
Below are recruiting pmmr/mss adenocarcinoma of the colon or rectum clinical trials, each written for real people, not researchers. We’re tracking 107 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07213193Recruiting
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RomaAges 18 years+ - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130 - NCT07115914Recruiting
PSMA PET scan to monitor prostate cancer after focal therapy
This trial uses a special PET scan (PSMA PET) to check if prostate cancer returns after focused treatment (focal therapy). It may help find any remaining cancer that standard scans miss.
Chicago, IllinoisAges 18 years+ - NCT07094204RecruitingPhase 1
Study of ASP5834 for advanced solid tumors with KRAS changes
This study tests a new drug (ASP5834) for people with advanced solid tumors that have changes in the KRAS gene. The study looks for a safe and effective dose, and may help you if your standard treatments have stopped working.
Santa Monica, CaliforniaAges 18 years+ - NCT07026422RecruitingPhase 2
Combination immunotherapy with chemoradiation for high-risk rectal cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy and radiation before surgery for people with a specific type of high-risk rectal cancer. The goal is to see if adding these drugs can improve treatment results.
Jinan, ShandongAges 18–75 - NCT07011576RecruitingPhase 2
Fruquintinib plus FOLFIRI for second-line metastatic colorectal cancer
This trial tests a combination of two drugs, fruquintinib and FOLFIRI chemotherapy, as a second treatment option for people with metastatic colorectal cancer. It is designed for patients who have already received one prior treatment containing oxaliplatin, fluoropyrimidine, and bevacizumab.
Denver, ColoradoAges 18 years+ - NCT06993402Enrolling by invitation
Düsseldorf ESD Study
This study is testing the use of ESD, a procedure to remove abnormal tissue from your digestive tract using a thin, flexible scope. It may be an option if you need this procedure in your esophagus, stomach, duodenum, colon, or rectum.
Düsseldorf, North Rhine-WestphaliaAges 18 years+ - NCT06958432RecruitingPhase 2/Phase 3
Shorter radiation before chemo and immunotherapy for rectal cancer
This trial tests a shorter course of radiation before chemotherapy and an immunotherapy drug to shrink mid-to-lower rectal cancer that has not spread. The goal is to improve treatment response and reduce side effects, potentially allowing for less invasive surgery.
Guangzhou, GuangdongAges 18–75 - NCT06919068Recruiting
Colon camera capsule for gut bacteria in the blood
This trial tests whether a camera capsule can detect problems in the large intestine when certain gut bacteria are found in the blood. If you have one of these bacteria and are stable enough for the exam, it might help identify the source of the infection.
OdenseAges 18 years+ - NCT06850090RecruitingPhase 3
Comparing two chemo drugs before radiation for rectal cancer
This trial tests if a newer chemo pill (TAS-102) works better than the standard pill (capecitabine) when given before radiation and surgery for rectal cancer. It is for people with stage II or III rectal cancer that has certain high-risk features.
Jinan, ShandongAges 18–75 - NCT06834126RecruitingPhase 1
Papaverine with radiation for advanced rectal cancer
This trial tests if adding papaverine (a drug) to radiation therapy can help people with locally advanced rectal cancer avoid surgery and keep their rectum. It is for patients who have already had chemotherapy and want a non-surgical approach.
Duarte, CaliforniaAges 18 years+ - NCT06783491RecruitingPhase 3
Chemotherapy with or without heated chemo for advanced colon cancer
This trial tests if adding heated chemotherapy directly into the abdomen during surgery improves outcomes for people with advanced colon cancer that hasn't spread to other organs. It compares standard chemotherapy before surgery alone versus chemotherapy before surgery plus heated chemo during surgery.
Córdoba, CórdobaAges 18–75 - NCT06780787RecruitingPhase 2
Study of chemo plus immunotherapy for localized rectal cancer before surgery
This trial tests a combination of chemotherapy (FOLFOX) and two immunotherapies (botensilimab and balstilimab) before surgery for patients with localized rectal cancer. It aims to see if adding immunotherapy helps shrink the tumor and improve outcomes.
Duarte, CaliforniaAges 18 years+ - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80 - NCT05732389RecruitingPhase 2
Immunotherapy for early rectal cancer with dMMR or MSI
This trial studies whether immunotherapy (nivolumab plus ipilimumab) can help people with early-stage rectal cancer that has dMMR or MSI changes. It’s meant for patients who have not yet had chemotherapy, radiation, or immunotherapy for colorectal cancer.
AalborgAges 18 years+ - NCT06669572RecruitingPhase 2
Lenvatinib and pembrolizumab for advanced anal or rectal cancer
This trial tests a combination of two drugs, lenvatinib and pembrolizumab, for people with anal or rectal cancer that has spread or cannot be removed and has worsened after initial treatment. The goal is to see if this combination can help shrink or control the cancer.
Chicago, IllinoisAges 18 years+ - NCT05476263Recruiting
Negative pressure wound therapy for esophagus or rectum
This trial studies whether a device called Suprasorb CNPendo helps healing of certain full-thickness (through-and-through) injuries or wounds in the esophagus or rectum. It may be an option if your medical team is already considering negative pressure wound therapy for these specific problems.
BerlinAges 18 years+ - NCT06317727Recruiting
Pulsed field ablation for removing colon polyps
This study tests a new way to remove colon polyps using short bursts of energy (pulsed field ablation) instead of standard methods. It may help people with polyps in the lower part of the colon that are not too large or complex.
LondonAges 18 years+ - NCT06238713Recruiting
New vs. standard robotic prostate surgery for early cancer
This study compares two ways of doing robot‑assisted prostate removal surgery. It aims to see if a newer, less invasive method through a single small cut is as safe and effective as the standard method. If you have early‑stage prostate cancer and are eligible, you could help improve surgical recovery.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06236633Recruiting
Blocking an artery before rectal cancer surgery
This trial tests a technique called ischemic preconditioning, where doctors temporarily block a main artery in your gut before rectal cancer surgery to see if it helps reduce complications. If you are scheduled for this type of surgery and meet the health criteria, the study may offer more information about safer recovery.
MontpellierAges 18–90 - NCT06245356RecruitingPhase 2
A safety trial of trifluridine/tipiracil for DPD-deficient patients
This trial tests a chemotherapy drug (trifluridine/tipiracil) in people with metastatic colorectal or gastroesophageal cancer who have a DPD deficiency. DPD deficiency means your body may have trouble breaking down certain chemotherapy drugs, which can lead to serious side effects. This study aims to see if this drug is safe and effective for you.
AmiensAges 18 years+ - NCT06134687Recruiting
New stiffening tube for colon lesion removal
This trial tests a new flexible tube that becomes stiff to help doctors remove large or complex colon lesions during an endoscopic procedure. It may help people with certain types of flat or scarred growths that are harder to remove safely.
Houston, TexasAges 22 years+ - NCT05941806RecruitingPhase 3
Preventing urinary retention after rectal surgery
This trial tests a medication called tamsulosin, given before and after rectal surgery, to see if it helps men urinate normally after the operation. It may help avoid the need for a temporary urinary catheter.
Québec, QuebecAges 18 years+ - NCT05772481Recruiting
PET-MRI scan test for rectal cancer after pre-surgery treatment
This study looks at whether a special scan called PET-MRI can better show how rectal cancer responds to treatment given before surgery. If it works well, it could help doctors plan the right next steps after chemoradiotherapy.
StrasbourgAges 18–75
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Common questions
- Are there clinical trials for pmmr/mss adenocarcinoma of the colon or rectum?
- Yes. Clin2 currently lists 107 recruiting pmmr/mss adenocarcinoma of the colon or rectum studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pmmr/mss adenocarcinoma of the colon or rectum trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.