Clinical trials
Positive Mental Health clinical trials
Below are recruiting positive mental health clinical trials, each written for real people, not researchers. We’re tracking 87 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05445180Recruiting
Brain scan study of thinking in cannabis users with psychosis
This study uses brain imaging to understand how thinking works in people who use cannabis, comparing those with psychosis to people without psychosis. It may help researchers learn what brain patterns relate to thinking difficulties and how cannabis use fits in.
Montreal, QuebecAges 16–80 - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT05744479RecruitingPhase 4
Metformin to reduce weight gain from antipsychotic medicines
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Toronto, OntarioAges 16–65 - NCT05851950Recruiting
Group CBT to reduce rumination in psychosis
This trial tests a structured group therapy (rumination-focused CBT) to help reduce repetitive negative thinking (“rumination”) that can worsen symptoms in people with psychosis. It may help you feel less stuck in unhelpful thoughts and improve day-to-day functioning while you continue your usual care.
CopenhagenAges 18–37 - NCT05859347Recruiting
Brain stimulation study for cannabis use disorder
This trial tests whether a treatment called repetitive transcranial magnetic stimulation (a non-surgical magnetic stimulation to the brain) can help people reduce or stop cannabis use. You may be eligible if you have cannabis use disorder and meet specific safety and symptom criteria.
Toronto, OntarioAges 18–65 - NCT05973110Recruiting
Virtual reality training to improve thinking in psychosis
This trial tests whether a virtual reality program can help people living with psychosis improve thinking and daily functioning. It may help if your symptoms are currently stable and you can safely use the VR equipment.
Ottawa, OntarioAges 18–60 - NCT06032377Recruiting
Online therapy for sleep and brain health in older adults
This study tests an online talk therapy program (CBT) to help older adults with both sleep troubles and mild memory or thinking concerns. It's done from home, and aims to improve sleep and brain health.
Ottawa, OntarioAges 60–99 - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT06141408Recruiting
PrEP for Black men in Prince George's County
This study looks at whether a new program can help Black men in Prince George's County, Maryland, start or stay on PrEP, a daily pill that prevents HIV. If you're HIV-negative and at risk, this could be a way to protect your health.
Fairfax, VirginiaAges 18 years+ - NCT06246214Recruiting
Biological rhythms for perinatal mental health
This study looks at whether understanding your body's daily rhythms (like sleep and activity) can help treat depression after childbirth. If you are 4-6 weeks postpartum and have been diagnosed with postnatal depression, this could be an option for you.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06351514RecruitingPhase 3
Accelerated brain stimulation for negative symptoms of schizophrenia
This trial tests a faster form of brain stimulation called accelerated intermittent theta burst stimulation to help with persistent negative symptoms of schizophrenia. Negative symptoms include things like lack of motivation, reduced emotion, or social withdrawal.
SingaporeAges 21–65 - NCT06456307Recruiting
Stepped care for mood and anxiety during pregnancy
This study tests a step-by-step approach to help pregnant women who are feeling anxious or down. If you are at least 28 weeks pregnant and feeling stressed, worried, or sad, the study will offer you support and check on how you are doing.
NairobiAges 14 years+ - NCT06587230Recruiting
Tealeaf-NC: Teacher-led support for students in North Carolina
This study tests the Tealeaf program, where teachers and school staff work together to support students who may be struggling emotionally or behaviorally. It aims to help students in kindergarten through 8th grade who have elevated scores on a behavior and emotions questionnaire.
Chapel Hill, North CarolinaAges 5–99 - NCT06604104Recruiting
Visual Frailty Study in Older Adults with AMD
This study looks at something called 'visual frailty' in older adults with advanced age-related macular degeneration (AMD). It aims to develop a tool to better understand how vision loss affects daily life and overall health in people aged 60 and over.
Edinburgh, ScotlandAges 60 years+ - NCT06635486Recruiting
Mental health support for Venezuelans in Lima
This study offers mental health support to Venezuelan adults living in Lima who are feeling anxious, depressed, or have experienced trauma. It will check if you have signs of depression, anxiety, or post-traumatic stress and provide help if you do.
LimaAges 18 years+ - NCT06680011Recruiting
Study of diagnostic markers for neurosyphilis
This study looks for better ways to diagnose neurosyphilis, an infection that affects the brain and spinal cord. Researchers will compare test results from people with neurosyphilis, people with syphilis but no brain involvement, and healthy volunteers.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06702722Recruiting
Therapy and HIV support for moms in Malawi
This study tests if combining problem-solving therapy with HIV care support can improve mental health and HIV outcomes for pregnant women living with HIV in Malawi who have elevated depressive symptoms.
LilongweAges 18 years+ - NCT06389565Recruiting
Change My Story: A mental health program for young adults with HIV
This study tests a mental health program to help young people living with HIV who feel down or depressed. It's designed to see if talking through your story can help you feel better and function day-to-day.
Ibadan, Oyo StateAges 16–29 - NCT07625345RecruitingPhase 1
Brain Imaging Study of PDE4B Using a Radioactive Tracer
This research study uses a special radioactive tracer and imaging machines (PET and MRI scans) to take pictures of a specific protein in your brain called PDE4B. This is an early-stage study to see if this imaging method works safely and can help us understand brain chemistry in the future.
Bethesda, MarylandAges 18–101 - NCT06809166RecruitingPhase 4
Contrave for weight loss in adults with obesity
This study tests whether a weight loss medication called Contrave can help adults with obesity lose weight by changing how their body uses energy and handles food. If you qualify, you will take Contrave and be monitored for several months.
Ottawa, OntarioAges 18–64 - NCT06845124RecruitingPhase 2
Testing CBD and naltrexone for alcohol craving
This trial is testing if taking cannabidiol (CBD) plus naltrexone can reduce alcohol craving in people with alcohol dependence. Naltrexone is already used to help with alcohol cravings, and CBD may add extra benefit.
Wiesloch, Baden-WurttembergAges 18–70 - NCT06888726Recruiting
Brain stimulation for negative symptoms in schizophrenia
This trial tests if a gentle electric current applied to your head can help with negative symptoms (like lack of motivation or emotion). You must have schizophrenia, take a common antipsychotic, and have some ongoing negative symptoms.
Shanghai, Shanghai MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for positive mental health?
- Yes. Clin2 currently lists 87 recruiting positive mental health studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a positive mental health trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a positive mental health trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.