Clinical trials
Post Operative Pain clinical trials
Below are recruiting post operative pain clinical trials, each written for real people, not researchers. We’re tracking 197 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07357233Recruiting
Comparing two methods for root canal pain relief in lower molars
This trial compares two different ways of cleaning and shaping the inside of a tooth (root canal) to see which one causes less pain afterward. It is for people with a specific type of tooth infection in a lower back molar.
AlexandriaAges 18–50 - NCT07386353RecruitingPhase 4
Comparing two ways to give pain medicine after C-section
This trial tests two different ways of giving morphine for pain relief after a planned cesarean section: one is injected into the spinal fluid and the other into the space around the spinal cord. The goal is to see which method works better and is safer.
Funchal, MadeiraAges 18 years+ - NCT02083835Recruiting
Study to improve pain after surgery using patient questionnaires
This trial studies how to better understand and improve pain after surgery by asking patients to complete short questionnaires. It may help hospitals find ways to reduce postoperative pain and better track recovery.
JenaAges 4 years+ - NCT07482709RecruitingPhase 1/Phase 2
Nerve block with or without ketamine for hysterectomy pain
This study compares two ways to reduce pain after a hysterectomy: a standard nerve block with bupivacaine (a numbing medicine) versus the same block plus ketamine (a medicine that can boost pain relief). The goal is to see if adding ketamine provides better comfort after surgery.
Karachi, SindhAges 25–65 - NCT07380139Enrolling by invitationPhase 1
Comparing two medications for nose surgery pain relief
This trial tests if two different medicines, dexamethasone and dexmedetomidine, given as a nerve block in your nose during rhinoplasty can better control pain after surgery.
CairoAges 18–65 - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT06460402Enrolling by invitation
Ice packs and warm baths after hemorrhoid surgery
This trial tests whether using ice packs and warm baths after hemorrhoid surgery helps wounds heal faster and reduces pain more than standard care. If you are having surgery to remove hemorrhoids, this study may offer a simple, gentle way to help you recover.
Kaohsiung CityAges 18–80 - NCT06350981Enrolling by invitationPhase 2/Phase 3
Pain control after lower back fusion surgery
This study is comparing different ways to manage pain after a specific type of lower back fusion surgery called TLIF. The goal is to find the best pain control plan to make recovery more comfortable.
Tampa, FloridaAges 18 years+ - NCT05816174Recruiting
Study of long-term pain after bone surgery in children
This study follows children and teens to learn how pain can last after planned orthopedic (bone) surgery in the hospital. It may help doctors better understand which kids are more likely to have long-lasting pain and how to support them.
BaselAges 8–18 - NCT06158620RecruitingPhase 1/Phase 2
Nasal spray for pain after ureter stent placement
This trial tests whether a nasal spray form of the painkiller ketorolac can safely reduce pain from a ureteral stent after stone surgery. If you are having a ureteroscopy with stent placement, this might help you manage discomfort without stronger medications.
Dallas, TexasAges 18 years+ - NCT06349772RecruitingEarly Phase 1
Pain relief after robotic sleeve gastrectomy: Zynrelef vs Exparel
This trial compares two long-acting pain medicines, Zynrelef and Exparel, to see which works better for pain control after robotic sleeve gastrectomy. The goal is to improve recovery and reduce the need for stronger painkillers.
Lubbock, TexasAges 18–65 - NCT06603961Recruiting
Preventing leg swelling after bypass surgery with a special bandage
This trial tests a custom pressure-guided elastic bandage to prevent leg swelling after coronary artery bypass surgery. The bandage is wrapped around the leg where a vein was taken for the bypass.
Bangkok, Bangkok NoiAges 18 years+ - NCT07164677Recruiting
Nerve block for pain after open-heart surgery
This study tests a nerve block (an injection near the back muscles) to see if it helps control pain after open-heart surgery. It might be a good option if you are having planned heart surgery through a cut in the middle of your chest.
SamsunAges 18–80 - NCT07548385RecruitingPhase 3
New pain medicine for after knee replacement surgery
This study tests a new medication called suzetrigine to help manage pain after knee replacement surgery. The goal is to see if it reduces pain and discomfort better than current treatments.
New York, New YorkAges 18–85 - NCT06483659RecruitingPhase 2
Oxytocin for pain after minimally invasive hysterectomy
This study tests if giving oxytocin (a natural hormone) through an IV can help reduce pain after a minimally invasive hysterectomy. If you are having this surgery, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT07745972Recruiting
Pain relief block for gallbladder surgery
This trial tests a numbing injection near the ribs to reduce pain after laparoscopic gallbladder removal. It may help you recover with less discomfort.
IstanbulAges 18–80 - NCT05841290Recruiting
Compare types of dental sealers for post-procedure pain
This study checks how much pain happens after dental procedures using different types of filling/sealing materials. It may help you and future patients understand which sealer options tend to cause less postoperative discomfort.
El Shorouk, Cairo GovernorateAges 18–50 - NCT06515691Recruiting
Nerve block for pain after weight loss surgery
This study tests a nerve block (an injection near the nerves) to see if it helps reduce pain after laparoscopic sleeve gastrectomy. The block is called a modified thoracoabdominal nerve plane block, and it may lead to better pain control and recovery.
Istanbul, BagcilarAges 18–65 - NCT07223580RecruitingPhase 4
Steroid use for pain after kidney stone surgery
This trial tests if giving a corticosteroid during ureteroscopy (a scope procedure to remove kidney or ureter stones) can reduce pain afterward. If you are having this surgery and are not already on steroids or strong pain medicines, this study may help manage your recovery.
Scottsdale, ArizonaAges 18 years+ - NCT07771816Enrolling by invitation
Mouth rinse and cold therapy for lower molar pain
This study tests whether using different strengths of a disinfectant rinse inside the tooth, sometimes combined with cold therapy, can reduce pain after a type of root canal treatment for lower molars. It aims to find the most comfortable and effective approach for managing post-procedure pain.
Cairo, Cairo GovernorateAges 15–40 - NCT07527039RecruitingPhase 4
Nerve Block for Pain Relief During Breast Reduction Surgery
This study tests a special numbing technique (pectoral block) to help control pain after breast reduction surgery in women with very large breasts causing symptoms like neck, shoulder, or back pain. The goal is to see if this nerve block reduces pain better than standard pain control methods.
Roanoke, VirginiaAges 18–75 - NCT05919745RecruitingPhase 4
Ibuprofen before mouth surgery to reduce pain sensing
This trial studies whether taking ibuprofen before tooth extraction and bone graft surgery can lower how much pain you feel afterward. It may help by changing the body’s pain response during healing.
Milwaukee, WisconsinAges 18 years+ - NCT06508814Recruiting
Pain with different gas pressures during laparoscopic hysterectomy
This trial compares two different gas pressure levels used during laparoscopic hysterectomy (a minimally invasive surgery to remove the uterus) to see which one causes less pain after the procedure. It may help you and your doctor choose the best pressure for your surgery.
Memphis, TennesseeAges 18–80 - NCT06838039Recruiting
A second nerve block for less pain after lung surgery
This study tests whether adding a second nerve block (serratus anterior block) within 24 hours after a lung surgery (VATS) can reduce pain better than the standard nerve block alone. It aims to help patients control pain with fewer strong painkillers.
HebronAges 18–70
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Common questions
- Are there clinical trials for post operative pain?
- Yes. Clin2 currently lists 197 recruiting post operative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a post operative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a post operative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.