Clinical trials
Psychological Distress clinical trials
Below are recruiting psychological distress clinical trials, each written for real people, not researchers. We’re tracking 74 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06172907Recruiting
Support for young adults with cancer and their partners
This study offers support to young adults (ages 25-39) with cancer and their partners. It aims to help couples manage stress during or after cancer treatment.
Boston, MassachusettsAges 25–39 - NCT06197711Recruiting
PRISMA for mental health in pretrial detention
This study tests whether a program called PRISMA can help improve mental health for people in pretrial detention. It is designed for detainees in Zurich and Bern who speak one of nine languages and are not in immediate crisis.
Zurich, Canton of ZurichAges 18 years+ - NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT06699732Recruiting
Mindful self-compassion therapy for borderline personality disorder
This study tests if a therapy focused on being kind to yourself can help reduce self-harm, improve emotional control, and boost quality of life. It is for people with borderline personality disorder who are not currently hospitalized.
Rawalpindi, Punjab ProvinceAges 18 years+ - NCT06389565Recruiting
Change My Story: A mental health program for young adults with HIV
This study tests a mental health program to help young people living with HIV who feel down or depressed. It's designed to see if talking through your story can help you feel better and function day-to-day.
Ibadan, Oyo StateAges 16–29 - NCT06732375Recruiting
Mindset Moments for young adult cancer survivors
This study looks at a simple online program called 'Mindset Moments' to help young adults (ages 19-25) who have finished cancer treatment feel better emotionally. You may join if you're still feeling some distress and want to try a new way to cope.
Durham, North CarolinaAges 19–25 - NCT06766526Recruiting
Online support for emotional adjustment after prostate cancer
This trial tests an online support program to help men cope with emotional distress after prostate cancer. You participate from home using a computer or smartphone.
LinköpingAges 18 years+ - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+ - NCT07003334Recruiting
Study on mental health and immune therapy for stomach cancer
This study looks at how psychological distress relates to immune checkpoint inhibitors in people with stomach cancer. It may help understand if emotional well-being affects treatment response.
Guangzhou, GuangdongAges 18–75 - NCT07151079Recruiting
Group therapy for trans teens feeling stressed
This study tests a group therapy program for teens who are trans or gender diverse and feeling stressed, anxious, or sad. The goal is to see if talking together in a group helps improve their well-being.
Parkville, VictoriaAges 12–17 - NCT07424209Recruiting
Hypnotic communication during heart catheterization study
This study tests whether talking in a special relaxed way (hypnotic communication) during a heart procedure can help you feel calmer and more comfortable. You may be able to join if you are at least 18, can understand Italian, and are already scheduled for a coronary angiogram.
Ponderano, ItalyAges 18 years+ - NCT07447089Recruiting
EMDR therapy for cancer patients with PTSD
This study tests a treatment combining group and individual EMDR therapy to help cancer patients who have post-traumatic stress disorder (PTSD) from their diagnosis or treatment.
MilanAges 18–100 - NCT07454070Recruiting
Testing ear nerve stimulation for depression after a heart attack
This trial tests if a gentle, non-invasive ear stimulation device can help relieve depression in people who have had a heart attack and a stent placed. It aims to offer a drug-free option for those who choose not to take antidepressants or see a therapist.
Xi'an, ShaanxiAges 18 years+ - NCT07481890Recruiting
EMDR therapy for cancer patients
This trial tests a short therapy method (EMDR toolbox) to help cancer patients cope with emotional distress. It may reduce anxiety and improve well-being.
Bellinzona, Canton TicinoAges 18–65 - NCT07615257Recruiting
Mindfulness and CBT for Psoriasis-Related Emotional Stress
This study tests whether a combination of mindfulness and cognitive behavioral therapy (CBT)—talk-based techniques to manage thoughts and emotions—can help psoriasis patients feel less stressed and more compassionate toward themselves. Participants attend sessions over several weeks to learn these skills.
Rahim Yar Khan, Punjab ProvinceAges 25–75 - NCT07617467Recruiting
Group therapy for emotional distress in young people
This trial tests whether group-based therapy (Acceptance and Commitment Therapy, or ACT) can help young people manage anxiety, depression, and stress. The therapy teaches skills to accept difficult feelings while living according to your values.
Arendal, AgderAges 16–25 - NCT07550166Enrolling by invitation
Mindfulness App Study for Korean Older Adults
This study tests whether a mindfulness app—guided exercises to help you relax and focus your mind—can improve wellbeing in Korean immigrants aged 60 and older. You'll use the app on your smartphone for 8 weeks.
Tampa, FloridaAges 60 years+ - NCT07356830Enrolling by invitation
Art therapy for infertility: stress and pregnancy study
This study tests whether art therapy sessions, led by a nurse, can help reduce stress and improve pregnancy chances for women with infertility. If you join, you'll take part in guided art activities and fill out questionnaires about your feelings.
Yiwu, ZhejiangAges 18–40 - NCT06822673Enrolling by invitation
Mind-Body Therapy for Children with Headaches
This study tests a mind-body therapy (MBI) to see if it can reduce headaches and improve well-being in children. It focuses on children aged 8 to 12 who get headaches and are otherwise healthy.
RawalpindiAges 8–12 - NCT04165460Enrolling by invitation
CBT programs for anxiety and coping in cervical cancer
This study tests two structured talk-therapy programs (cognitive-behavioral therapy) to help people with cervical cancer manage anxiety, depression symptoms, and unhelpful coping skills. It also looks at the role of a main caregiver during care planning and support.
Mexico City, TlalpanAges 18 years+ - NCT07455370Enrolling by invitation
Moral distress and stress study for nurses
This study looks at how work-related stress and moral challenges affect nurses. It aims to understand and improve support for nursing staff.
Phoenix, ArizonaAges Any age - NCT06590727Recruiting
Emotional health in breast cancer patients
This study looks at how surgery or cancer treatments affect the emotional well-being of people with breast cancer. It aims to understand your feelings and mental health during treatment.
RomaAges 18 years+ - NCT07626944Recruiting
Music and Sound Therapy for Dementia Behaviors
This study tests whether special music and sound patterns can help reduce difficult behaviors and improve mood in people with dementia living in assisted care. Researchers will play these sounds to you and track any changes in how you feel and behave.
Denver, ColoradoAges 55–95 - NCT06461780Recruiting
Needs and Quality of Life in Advanced Cancer on Immunotherapy
This study looks at the physical and emotional needs of people with advanced cancer who are receiving immunotherapy. It aims to understand how these needs affect quality of life.
TaipeiAges 18 years+
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Common questions
- Are there clinical trials for psychological distress?
- Yes. Clin2 currently lists 74 recruiting psychological distress studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a psychological distress trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a psychological distress trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.