Clinical trials
Psychological Distress clinical trials
Below are recruiting psychological distress clinical trials, each written for real people, not researchers. We’re tracking 79 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07454070Recruiting
Testing ear nerve stimulation for depression after a heart attack
This trial tests if a gentle, non-invasive ear stimulation device can help relieve depression in people who have had a heart attack and a stent placed. It aims to offer a drug-free option for those who choose not to take antidepressants or see a therapist.
Xi'an, ShaanxiAges 18 years+ - NCT07447089Recruiting
EMDR therapy for cancer patients with PTSD
This study tests a treatment combining group and individual EMDR therapy to help cancer patients who have post-traumatic stress disorder (PTSD) from their diagnosis or treatment.
MilanAges 18–100 - NCT07424209Recruiting
Hypnotic communication during heart catheterization study
This study tests whether talking in a special relaxed way (hypnotic communication) during a heart procedure can help you feel calmer and more comfortable. You may be able to join if you are at least 18, can understand Italian, and are already scheduled for a coronary angiogram.
Ponderano, ItalyAges 18 years+ - NCT06766526Recruiting
Online support for emotional adjustment after prostate cancer
This trial tests an online support program to help men cope with emotional distress after prostate cancer. You participate from home using a computer or smartphone.
LinköpingAges 18 years+ - NCT07356830Enrolling by invitation
Art therapy for infertility: stress and pregnancy study
This study tests whether art therapy sessions, led by a nurse, can help reduce stress and improve pregnancy chances for women with infertility. If you join, you'll take part in guided art activities and fill out questionnaires about your feelings.
Yiwu, ZhejiangAges 18–40 - NCT07195019Recruiting
Women's Wellbeing Study for survivors of violence
This study tests whether a specially-designed yoga program can help women who have experienced interpersonal violence feel better. You would participate in yoga sessions and assessments to see if it reduces distress.
Providence, Rhode IslandAges 18–65 - NCT07151079Recruiting
Group therapy for trans teens feeling stressed
This study tests a group therapy program for teens who are trans or gender diverse and feeling stressed, anxious, or sad. The goal is to see if talking together in a group helps improve their well-being.
Parkville, VictoriaAges 12–17 - NCT07136948Recruiting
Mindfulness plus body-sensor training for stress relief
This study tests whether mindfulness training paired with a special shirt that tracks your breathing and heart rate can help reduce stress. You'll be assigned to one of two groups and give feedback on your experience.
Pittsburgh, PennsylvaniaAges 18–30 - NCT07003334Recruiting
Study on mental health and immune therapy for stomach cancer
This study looks at how psychological distress relates to immune checkpoint inhibitors in people with stomach cancer. It may help understand if emotional well-being affects treatment response.
Guangzhou, GuangdongAges 18–75 - NCT06979089Recruiting
Stress relief program for Dutch SMEs
This trial tests an online stress-management program for employees in small to medium-sized businesses in the Netherlands. It aims to help people with high stress levels feel better and cope more effectively.
Amsterdam, North HollandAges 18 years+ - NCT06941324Recruiting
Therapy to help teens and young adults with cancer feel better
This study tests a short-term therapy called Solution-Focused Brief Therapy to help teens and young adults with cancer reduce emotional distress. It's designed for people who are currently in treatment or have finished treatment within the last 5 years.
Ann Arbor, MichiganAges 15–39 - NCT06878092Recruiting
A support program for young refugees with emotional distress
This trial tests a program called Problem Management Plus with Emotional Processing (PM+EP) for youth who were forced to leave their home country. It aims to reduce stress and improve daily functioning. If you are a young refugee between 16 and 25 years old and feel very anxious or down, this might help you learn ways to cope.
StockholmAges 16–25 - NCT06822673Enrolling by invitation
Mind-Body Therapy for Children with Headaches
This study tests a mind-body therapy (MBI) to see if it can reduce headaches and improve well-being in children. It focuses on children aged 8 to 12 who get headaches and are otherwise healthy.
RawalpindiAges 8–12 - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+ - NCT06732375Recruiting
Mindset Moments for young adult cancer survivors
This study looks at a simple online program called 'Mindset Moments' to help young adults (ages 19-25) who have finished cancer treatment feel better emotionally. You may join if you're still feeling some distress and want to try a new way to cope.
Durham, North CarolinaAges 19–25 - NCT06575673Recruiting
Online skills training to help smokers quit and feel better
This trial tests an internet-based program that teaches skills to help you quit smoking and manage stress, anxiety, or low mood. You'll use your own device to get support and learn new ways to cope.
Tai Po, New TerritoriesAges 18–64 - NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT06389565Recruiting
Change My Story: A mental health program for young adults with HIV
This study tests a mental health program to help young people living with HIV who feel down or depressed. It's designed to see if talking through your story can help you feel better and function day-to-day.
Ibadan, Oyo StateAges 16–29 - NCT06279013Recruiting
Phone check-ins to manage symptoms during oral cancer treatment
This study tests two ways of using telephone check-ins to help people manage side effects and emotional distress while taking oral anti-cancer pills at home. If you are starting or recently started an oral anti-cancer drug, you may be able to join.
Phoenix, ArizonaAges 18 years+ - NCT06002191Recruiting
A text-based safety program for teens bullied online
This study tests a texting program called imHere4U to help teens who have been cyberbullied and feel distressed or think about suicide. The program aims to provide support and reduce suicide risk.
Pittsburgh, PennsylvaniaAges 12–17 - NCT05722236Recruiting
Peer support program to help people manage stress from IBD
This trial tests a “peer-to-peer” support program to help adults with inflammatory bowel disease (IBD) manage psychological distress (stress and emotional strain). It may help you cope better during major life or treatment changes related to IBD.
Halifax, N.S.Ages 18–99 - NCT05676255RecruitingPhase 2
SUPORT study for breast cancer survivors and their partners
This Phase 2 study looks at an online program for breast cancer survivors and their supportive partners who live together. The goal is to see whether the program helps survivors and partners during survivorship and adjustment after treatment.
Tucson, ArizonaAges 18 years+ - NCT05436106Recruiting
Reducing stress with a behavioral program for Black gender minority women
This trial tests a behavior-based program meant to help lower stress. It is designed for Black gender minority women who were assigned male at birth.
Atlanta, GeorgiaAges 18–99 - NCT04626050Recruiting
PTSD and stress support study for healthcare workers
This study looks at psychological distress, including post-traumatic stress disorder (PTSD), in healthcare workers after work-related trauma. You may be eligible if you are an adult healthcare worker with PTSD (and otherwise stable) who can complete regular study check-ins.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for psychological distress?
- Yes. Clin2 currently lists 79 recruiting psychological distress studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a psychological distress trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a psychological distress trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.