Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06357442Recruiting
Comparing progesterone methods for young people on estrogen therapy
This study compares two ways to give progesterone to young people on estrogen replacement therapy to see how they affect the lining of the uterus. It will help find which approach may be safer and more effective for your health.
Aurora, ColoradoAges 12–25 - NCT06381271Recruiting
TAVR for severe aortic valve regurgitation
This trial tests a procedure called TAVR to replace the aortic valve in people with severe aortic regurgitation (a leaky valve). It may help you if you have this condition and prefer a less invasive option than open-heart surgery.
Xi'an, ShannxiAges 18 years+ - NCT06403839Recruiting
Dental check before valve surgery to prevent infection
This study tests whether a dental check-up before heart valve surgery can help lower the risk of a serious heart infection after the operation.
OdenseAges 18 years+ - NCT06414265Recruiting
Testing a new valve for severe mitral regurgitation
This trial tests a new device called the SATURN system, which places a new mitral valve without open-heart surgery. It is for people aged 65 and older with severe mitral regurgitation who are at high risk for surgery.
TbilisiAges 65 years+ - NCT06430528Recruiting
Osilodrostat and steroid replacement for Cushing syndrome
This trial tests a new approach, called 'block-and-replace', for treating Cushing syndrome. You will take osilodrostat to lower high cortisol levels, along with a glucocorticoid (a steroid) to replace what your body needs. This study may help control the disease if surgery hasn't worked or isn't an option.
Ann Arbor, MichiganAges 18–75 - NCT06446739Recruiting
Low-dose vs standard-dose kidney therapy for ICU patients
This study compares two different doses of continuous kidney replacement therapy (CRRT, a type of dialysis) for patients in the intensive care unit with acute kidney injury. It aims to find out if a lower dose is as safe and effective as the standard dose.
Rochester, MinnesotaAges 18 years+ - NCT06493994Recruiting
Looking at Myval valve placed through the armpit
This study collects information on people who have already received a new aortic valve through a small cut in their armpit using the Myval valve. Doctors want to see how well this approach works over time.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT06522087Recruiting
40 Hz brain stimulation to prevent confusion after hip or knee replacement
This trial tests if a non-invasive 40 Hz brain stimulation can prevent delirium (sudden confusion) in older adults after hip or knee replacement surgery. Delirium is common after surgery in elderly patients, and this treatment aims to lower that risk.
Zhengzhou, HenanAges 65–85 - NCT06544473RecruitingPhase 4
Estrogen pill vs. patch for Turner syndrome
This trial compares oral and transdermal (patch) estrogen to find the right dose for women with Turner syndrome. It aims to see which method works best for hormone replacement.
Aarhus, Aarhus NAges 18–50 - NCT06589063Recruiting
TAVR for severe low flow, low gradient aortic stenosis
This study tests whether TAVR (a minimally invasive valve replacement) helps people with a specific type of severe aortic stenosis where the heart doesn't pump as strongly. It aims to see if the procedure improves symptoms and outcomes.
SalernoAges 18 years+ - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT06679816RecruitingPhase 4
Hydrocortisone for hormone replacement in large pituitary tumor surgery
This trial tests hydrocortisone as hormone replacement therapy after surgery for large pituitary tumors. It aims to help patients maintain healthy cortisol levels during recovery.
Beijing, Beijing MunicipalityAges 18–70 - NCT06688448Recruiting
New biologic aortic valve replacement study
This study is testing a new generation of biologic (tissue) replacement valves for the aortic valve in adults aged 18 to 65. It aims to see how well these newer devices work compared to standard options.
São Paulo, São PauloAges 18–65 - NCT06722066Recruiting
TAVR and heart valve calcium study
This study looks at how calcium buildup in the aortic valve affects long-term results after a TAVR procedure (a minimally invasive heart valve replacement). It may help doctors understand which patients do better over time.
SeoulAges 19 years+ - NCT06829433Recruiting
Knee arthritis and walking study
This study looks at how people with knee arthritis or a knee replacement walk and move. It aims to find better ways to measure knee function and improve treatments.
Portsmouth, HampshireAges 40–85 - NCT06830499Recruiting
Sapien 3 valve for younger Chinese patients with severe aortic stenosis
This trial tests a newer artificial heart valve (Sapien 3) placed through a small tube in the leg, for younger people (50–70) with severe aortic stenosis. It aims to see if this less invasive option works well in this age group.
Xi'an, ShaanxiAges 50–70 - NCT06832085RecruitingPhase 4
Comparing stop-smoking medications for adult smokers in Ontario
This study compares three different stop-smoking treatments—nicotine patches, cytisine, or varenicline—to see which works best. If you want to quit or cut down in the next six months, this could help you find the right medication.
Ottawa, OntarioAges 18 years+ - NCT06862180Recruiting
Meal replacement for diabetes control trial
This trial tests whether replacing one meal a day with a special shake can help people with type 2 diabetes improve their blood sugar control and overall health. If you have type 2 diabetes, take diabetes pills, and your blood sugar is not well controlled (HbA1c 7–10%), you may be able to join.
Kubang Kerian, KelantanAges 30–65 - NCT06889974Recruiting
Timing of kidney treatment in tumor lysis syndrome
This study looks at when to start kidney dialysis for patients in the ICU who develop tumor lysis syndrome (a rapid breakdown of cancer cells after chemotherapy that can harm the kidneys). It aims to find the best timing for this treatment.
AngersAges 18 years+ - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT06931054Recruiting
Acupuncture, ear acupressure and nicotine patches for quitting smoking
This trial tests whether adding acupuncture and ear acupressure to nicotine replacement therapy helps people quit smoking. If you smoke at least 10 cigarettes a day, are 18 or older, and can read Chinese, you may be eligible.
Hong KongAges 18 years+ - NCT06968143Recruiting
Patient Satisfaction With Smart Knee Implants Trial
This trial looks at how satisfied patients are with a new 'smart' knee implant that tracks motion and function. If you are getting a total knee replacement, you might be able to join and help compare the smart implant with standard implants.
Chicago, IllinoisAges 18 years+ - NCT07058623Recruiting
Nurse-led telehealth vs in-person follow-up after knee replacement
This trial compares follow-up care with a nurse via video calls or phone versus in-person visits after your first total knee replacement. It aims to see if telehealth is as good as in-person for your recovery.
Hong KongAges 18 years+ - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 502 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.