Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 507 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05927090Enrolling by invitation
Repair outcomes after acute aortic dissection surgery
This study looks at how patients do after surgery for an urgent (acute) tear of the aorta or related bleeding in the wall of the ascending aorta. It may help doctors better understand what outcomes to expect after early emergency surgery.
Saint-DenisAges 18–90 - NCT03328611Recruiting
Joint replacement outcomes database for degenerative joint disease
This study collects information about people with “wear-and-tear” joint disease who need joint replacement. The goal is to better understand outcomes after surgery and improve future care.
Indianapolis, IndianaAges Any age - NCT07864896RecruitingPhase 3
Study of a new pain medicine after knee replacement surgery
This trial tests a new oral pain medicine called suzetrigine for people who have a knee replacement. It aims to see if it helps control pain after surgery better or with fewer side effects than usual care.
New York, New YorkAges 18–80 - NCT07321899Recruiting
Study of a new tricuspid valve replacement device for severe leakage
This trial tests a new device called the Medtronic Intrepid TTVR system to replace the tricuspid valve in people with severe tricuspid regurgitation (leaky valve). It aims to see if the device can safely and effectively fix the leak and improve symptoms.
Birmingham, AlabamaAges 18 years+ - NCT06883578Recruiting
Effect of a low valine diet on body weight and metabolism
This trial studies if a diet low in valine, a building block of protein, can help people with excess weight lose weight and improve their metabolic health. It may offer an alternative approach for weight loss.
Shanghai, Shanghai MunicipalityAges 16–80 - NCT07226700RecruitingPhase 3
Suzetrigine for pain after hip replacement surgery
This study tests an investigational pain medicine called suzetrigine to see how well it controls pain after total hip replacement surgery. It is for adults 18–80 who are having a first-time hip replacement and can receive spinal anesthesia.
New York, New YorkAges 18–80 - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT07871487Recruiting
Brain protein changes after hip or knee replacement surgery
This study looks at whether having hip or knee replacement surgery with spinal anesthesia affects certain proteins in the brain that are linked to memory and thinking. It compares people having surgery with people who have arthritis but are not having surgery, to help understand if the surgery causes any short-term brain changes.
UppsalaAges 55–75 - NCT06570460RecruitingPhase 4
Estrogen pills vs. patch for Turner syndrome
This study compares two ways of taking estrogen (pills or a skin patch) in women with Turner syndrome to see which works better over time. It also includes healthy women for comparison.
Aarhus, Aarhus NAges 18–50 - NCT07709858Recruiting
Outcomes after TAVR for severe aortic valve disease
This is a registry study that tracks how people do after a TAVR procedure for a severely narrowed aortic heart valve. It helps doctors learn more about long-term outcomes and improve care for future patients.
SeoulAges 18 years+ - NCT07692217Recruiting
Joint health study for severe hemophilia A patients on new therapies
This study checks joint health and bleeding risk in people with severe hemophilia A who are taking newer factor VIII treatments or emicizumab. It uses ultrasound and blood tests to see how well these therapies protect joints.
Dallas, TexasAges 6 months+ - NCT05760924Recruiting
Testing a new heart pacing method for CRT nonresponders
This trial tests whether a different pacing approach called left bundle branch pacing can improve outcomes and heart structure changes in people who did not improve with standard biventricular CRT. It may help some patients with ongoing heart failure symptoms and weak heart pumping.
TomskAges 18–80 - NCT05450185Recruiting
Test filter lifespan during continuous kidney dialysis
This study looks at whether the lifespan (how long they can be used) of dialysis filters can be optimized during continuous kidney dialysis for very sick adults. If successful, it may improve care and use of dialysis supplies for people with dialysis-dependent kidney injury.
InnsbruckAges 18 years+ - NCT07516444Recruiting
Tricuspid valve replacement using a new catheter device
This trial tests a new device that replaces a leaky tricuspid valve (a heart valve) without open-heart surgery. If your tricuspid valve isn't working well and medicines haven't helped enough, this procedure might improve your heart function and symptoms.
Minneapolis, MinnesotaAges 18 years+ - NCT07514650Recruiting
Citrate Blood Thinner Safety in Critical Kidney Care
This study tests whether a specific blood-thinning method using citrate works safely and effectively in critically ill patients whose kidneys have suddenly stopped working and need a special filtering machine. Researchers want to confirm that this approach prevents dangerous blood clots while keeping patients safe.
Barcelona, BarcelonaAges 18 years+ - NCT07516145Recruiting
Robotic catheter repair for leaky tricuspid heart valve
This trial tests a new robotic catheter procedure to repair a leaky tricuspid valve (the valve on the right side of your heart). Instead of open-heart surgery, doctors thread a tiny device through a vein in your neck to fix the valve. It may be an option if you have severe leaking and your heart team thinks surgery is too risky for you.
ShatinAges 18–90 - NCT07465159Recruiting
Prehabilitation for frail patients before hip or knee replacement
This study tests whether a 'prehabilitation' program (tailored exercise and nutrition support before surgery) helps older patients who are frail recover better after hip or knee replacement. Participants will be randomly assigned to either the prehabilitation group or the usual care group.
ReykjavikAges 70 years+ - NCT07471243Recruiting
Dressing and wound care experiences after hip or knee replacement
This study looks at how people care for their surgical wounds and dressings after hip or knee replacement surgery. It aims to learn what helps patients feel more comfortable and confident in their recovery.
Bournemouth, DorsetAges 18 years+ - NCT06817148Recruiting
TAVR vs surgery for bicuspid aortic valve disease
This study compares two treatments for severe aortic stenosis in people with a bicuspid aortic valve: transcatheter aortic valve replacement (TAVR, a less invasive procedure) and surgical aortic valve replacement (SAVR, open-heart surgery). The goal is to see which approach works better for this specific condition.
Los Angeles, CaliforniaAges 50 years+ - NCT07362589Enrolling by invitation
Does pain education before knee or hip replacement help?
This study tests whether a special education session before knee or hip replacement surgery can help reduce anxiety, pain, and the need for pain medicine after surgery. If you are scheduled for joint replacement and can take part in a short learning session, you may be eligible.
Istanbul, KayişdağiAges 18 years+ - NCT07267117Recruiting
Heart valve disease progression and outcomes study
This study is following people with heart valve disease (leaky or narrowed valves) to understand how the disease changes over time and what problems it may cause. It does not test a new treatment, but helps doctors learn more about valve disease progression.
Fuzhou, FujianAges 18 years+ - NCT07262320Recruiting
Kidney treatment in Latin American ICUs
This study looks at how dialysis (renal replacement therapy) is used for patients in intensive care units (ICUs) with severe acute kidney injury in Latin America. Your participation can help improve care for people with kidney problems.
CochabambaAges 18 years+ - NCT07223151Recruiting
A taste test to help teens drink fewer sugary sodas
This study tests whether a special way of tasting sweet drinks can help teens who love sugary beverages cut back on them. It might help you reduce sugar and improve your health.
Bloomington, IndianaAges 12–18 - NCT06936631Recruiting
Comparing catheter replacement in urinary tract infections
This study tests whether replacing a urinary catheter early during a catheter-related infection leads to better outcomes than keeping it in place. It may help people who have had a catheter for at least two weeks and develop a urinary tract infection.
Leiden, South HollandAges 18 years+
Hear when a new Replacement trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 507 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.