Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07069673Recruiting
Abbott Cephea mitral valve disease registry
This study tracks people with mitral valve disease who receive the Cephea valve through a tube in an artery rather than open-heart surgery. It looks at how well the valve works over time.
Birmingham, AlabamaAges 18 years+ - NCT07107568Recruiting
Testing ways to check heart arteries before valve replacement
This trial compares different methods to evaluate coronary artery disease in patients planning to have a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. The goal is to find out if a less invasive approach is as safe and effective as the standard one.
InnsbruckAges 18 years+ - NCT07109557Recruiting
Baduanjin for recovery after knee replacement
This study tests whether doing Baduanjin, a gentle mind-body exercise, helps people recover better after knee replacement surgery. It focuses on patients who are in stable condition and willing to try the exercise.
YalovaAges 18–70 - NCT07125469Recruiting
Comparing CT scan measurements to surgery findings for aortic valve replacement
This study checks if measurements taken from a CT scan before surgery match the actual size of the valve measured during surgery. It may help doctors choose the best valve size for people with severe aortic stenosis who need valve replacement.
Cotignola, RavennaAges 18 years+ - NCT07168330Recruiting
How well does ankle replacement work? A long-term look
This study checks how well total ankle replacements work over time, using patient reports and X-rays. It may help you understand your own recovery and improve care for others.
MilanAges 18–90 - NCT07278323RecruitingPhase 4
Hormone therapy for frozen shoulder
This study tests if hormone replacement therapy can help treat frozen shoulder. It is designed for people with frozen shoulder in just one shoulder who are not currently using hormones and have no history of hormone-sensitive cancer.
San Francisco, CaliforniaAges 40 years+ - NCT07299942Recruiting
Beta-glucan supplement for weight loss in women
This trial tests whether taking a beta-glucan supplement (a type of fiber) during a calorie- and carb-restricted diet helps with losing body weight and fat, controlling appetite, and managing hunger hormones. It is for healthy women who are overweight or obese and not following a special diet.
GlasgowAges 18–60 - NCT07334691Recruiting
Trial of a new tricuspid valve replacement device
This trial tests a new catheter-based device to replace your tricuspid valve without open-heart surgery. It's for people with severe tricuspid regurgitation who are at high risk for surgery.
BonnAges 18–85 - NCT07366502Recruiting
Liposomal vs Regular Oral Iron After Sleeve Gastrectomy
This trial compares two types of oral iron supplements for people who have iron deficiency anemia after a sleeve gastrectomy. It aims to find which type is more effective at raising iron levels.
Istanbul, kadıköyAges 18–65 - NCT07394296Recruiting
Study on midline catheter replacements
This study looks at why midline catheters (a type of IV line) need to be replaced in patients. It will help understand how often this happens and the reasons behind it.
ValenciennesAges 18 years+ - NCT02836262Recruiting
New hip replacement implant for painful worn-out hip joints
This trial studies a specific hip replacement implant system in people whose hip pain is from worn-out (non-inflammatory) joint disease like osteoarthritis. It compares outcomes by tracking pain and function before and after surgery, and you must be able to return for follow-up visits.
Winnipeg, ManitobaAges 65–79 - NCT07437469Recruiting
Binaural beats for pain and anxiety after surgery
This trial tests if listening to binaural beats (a type of sound therapy) after hip or knee replacement surgery can help reduce pain and anxiety. You would receive the sound therapy through headphones while in the recovery room.
Miami, FloridaAges 18–99 - NCT07455292Recruiting
Heart valve study using advanced MRI
This study uses a special type of MRI, called 4D flow MRI, to better understand how severe aortic stenosis (a narrowed heart valve) affects heart function. It may help doctors learn more about different types of this condition and improve future treatment.
San Donato MilaneseAges 18 years+ - NCT07487818RecruitingPhase 2/Phase 3
Vagus nerve stimulation with nicotine patch for quitting smoking
This study tests if a gentle electrical stimulation of a nerve in your neck can help you quit smoking when used with nicotine replacement therapy (patches or gum). It might offer a new way to reduce cravings and withdrawal.
Rochester, MinnesotaAges 18 years+ - NCT07548385RecruitingPhase 3
New pain medicine for after knee replacement surgery
This study tests a new medication called suzetrigine to help manage pain after knee replacement surgery. The goal is to see if it reduces pain and discomfort better than current treatments.
New York, New YorkAges 18–85 - NCT07556003Recruiting
Physical Therapy After Knee Replacement Surgery
This study tests whether a physical therapy program helps improve walking ability and foot pressure patterns in women who have had knee replacement surgery or have knee problems. The goal is to see if structured rehabilitation helps you walk better and more comfortably.
SakakahAges 40–70 - NCT07569848Recruiting
Custom ankle replacement for severe bone loss
This study tests a custom-designed ankle replacement device for people with severe ankle bone damage or loss. The device is made specifically for each patient at the Rizzoli Institute in Italy to help restore ankle function and reduce pain.
BolognaAges 35–75 - NCT07651462Recruiting
Fasting Before Hip Surgery and Gut Health
This study tests whether fasting for 20 days before hip replacement surgery changes your gut bacteria in ways that might help your recovery. Researchers want to understand if this dietary approach affects how well you heal after the operation.
Berlin, State of BerlinAges 18–75 - NCT07122323Enrolling by invitation
Robot-assisted hip replacement for Legg-Calve-Perthes disease
This trial compares robot-assisted total hip replacement to the usual surgery for people with Legg-Calve-Perthes disease. It aims to see if the robotic arm helps the surgery go more smoothly.
Hangzhou, ZhejiangAges 18–80 - NCT06311331Enrolling by invitation
Total talus replacement for ankle bone damage
This trial tests a new total talus replacement implant for people with severe talus bone problems like avascular necrosis, non-healing fractures, or large bone defects. It aims to see how well the implant works and how patients recover.
Charlotte, North CarolinaAges 22 years+ - NCT03249428Enrolling by invitation
Cytisine vs nicotine patches for quitting smoking
This study compares cytisine (an aid to reduce cravings) with nicotine replacement therapy (like patches or gum) to help people quit tobacco/nicotine. It also looks at whether the two options work for people facing higher barriers like low income or housing insecurity.
Ottawa, OntarioAges 18 years+ - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT07761273Enrolling by invitation
Tricuspid valve repair using heart tissue
This study tests a new way to repair the tricuspid valve (the valve that controls blood flow on the right side of your heart) using a piece of your own heart tissue called the right atrial appendage. This might be an option for people who need this type of valve surgery.
Zagazig, Sharqia ProvinceAges 18–70 - NCT06371833Recruiting
Shoulder replacement study for arthritis or rotator cuff tears
This study is testing two types of shoulder replacement implants (one for arthritis and one for rotator cuff tears) to see how well they work over time. It may be a good option if you have severe shoulder pain from arthritis or a torn rotator cuff.
Cattolica, RiminiAges 18 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 502 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.