Clinical trials
Rheumatoid arthritis clinical trials
An autoimmune condition that causes painful swelling in the joints. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06492200Recruiting
High-Fiber Diet for Rheumatoid Arthritis
This study tests whether eating more high-fiber foods can improve rheumatoid arthritis symptoms by changing the bacteria in your gut. You would follow a special diet and have your disease activity monitored.
WürzburgAges 18–99 - NCT06503237Recruiting
SWK002 for tough-to-treat rheumatoid arthritis
This trial tests a new treatment called SWK002 for people with rheumatoid arthritis that hasn't improved after trying multiple medications. It aims to see if SWK002 can help when other treatments have failed.
Changsha, HunanAges 18 years+ - NCT06596772RecruitingPhase 3
Comparing a biosimilar to Enbrel for rheumatoid arthritis
This trial tests if a new biosimilar called MB04 works as well as the standard drug Enbrel for people with moderate to severe rheumatoid arthritis. Participants will keep taking methotrexate while being assigned to one of the two drugs to see how they compare.
HaskovoAges 18–75 - NCT06628206RecruitingPhase 1
Testing LPX-TI641 for rheumatoid and psoriatic arthritis
This trial tests a new drug, LPX-TI641, to see if it is safe and how it works in the body for people with rheumatoid arthritis or psoriatic arthritis. It may be an option if you have active joint swelling and pain despite standard treatments.
AmmanAges 18 years+ - NCT06630715Recruiting
Comparing Upadacitinib for Psoriatic and Rheumatoid Arthritis
This study tests whether the medication upadacitinib (Rinvoq) works similarly for psoriatic arthritis and rheumatoid arthritis. Participants will have ultrasound imaging to track joint inflammation while taking upadacitinib.
Legnano, MilanoAges 18 years+ - NCT06649136RecruitingPhase 4
Maximizing methotrexate therapy for active rheumatoid arthritis
This trial tests whether increasing your methotrexate dose or switching from pills to injections can better control active rheumatoid arthritis. It's for people already taking a stable, moderate dose of methotrexate but still having joint swelling and symptoms.
Vienna, State of ViennaAges 18–99 - NCT06671054RecruitingPhase 2
Testing AP1189 for newly diagnosed active rheumatoid arthritis
This study tests an oral drug called AP1189 for people just diagnosed with active rheumatoid arthritis who haven't yet taken standard arthritis medicines. You may be able to take part if your disease is very active and you're ready to try a new treatment option.
Cutler Bay, FloridaAges 18 years+ - NCT07293871Recruiting
Ultrasound treatment for rheumatoid arthritis
This trial tests whether ultrasound waves applied to the spleen can reduce inflammation in adults with rheumatoid arthritis. It is for people with moderate to severe disease who have not tried many biologic medications.
Colleyville, TexasAges 18 years+ - NCT06718569Recruiting
Pain in Inflammatory Joint Diseases
This study looks at pain in people with inflammatory joint diseases. It aims to understand how pain changes when you start or switch to a newer type of arthritis medication.
OsloAges 18 years+ - NCT06769386Recruiting
Muscle Oxygen in Rheumatoid Arthritis
This study looks at how muscles use oxygen in people with rheumatoid arthritis. You will do some exercise tests to measure your muscle oxygen levels, which may help doctors understand how the disease affects your muscles.
Kırşehir, MerkezAges 18–65 - NCT06812481Recruiting
Anticholinergic drugs and bone health in rheumatoid arthritis
This study looks at whether a type of medication (anticholinergic drugs) used for other conditions affects bone health in people with rheumatoid arthritis. It will help doctors understand if these drugs increase the risk of osteoporosis (weak bones) and if they should be avoided.
BalıkesirAges 18 years+ - NCT06841562Recruiting
Home Exercise and Anti-inflammatory Program for Early RA
This study tests if a home-based exercise program, combined with anti-inflammatory strategies, can help people newly diagnosed with rheumatoid arthritis manage their symptoms and improve health. It's a remote program, so you can participate from home.
Durham, North CarolinaAges 18 years+ - NCT06857227RecruitingPhase 1
Study of GNC-038 for active rheumatoid arthritis
This trial tests a new experimental antibody called GNC-038 for people with moderate to severe rheumatoid arthritis (RA) that hasn't responded well enough to standard treatments. It aims to see if targeting specific immune cells can reduce inflammation and improve symptoms.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06887127RecruitingPhase 3
Long-term safety study of TLL-018 for rheumatoid arthritis patients
This study offers continued access to TLL-018 for people with rheumatoid arthritis who completed the earlier study (TLL-018-301). It checks long-term safety and helps researchers understand if the medicine remains effective over time.
Beijing, Beijing MunicipalityAges 18–75 - NCT06889415Recruiting
Rheumatoid Arthritis and Bone & Muscle Loss: A Study
This study looks at how rheumatoid arthritis relates to bone thinning and muscle loss in people over 50. It aims to find what factors are linked to these conditions.
Konya, SelçukluAges 50 years+ - NCT06902519RecruitingPhase 1
Study of a new drug for rheumatoid arthritis
This trial tests an experimental drug for people with rheumatoid arthritis who have not had success with other treatments. It aims to see if the drug can help reduce joint pain and swelling.
Anniston, AlabamaAges 18–75 - NCT06906549RecruitingPhase 4
Testing a lower dose of rituximab every 6 months for rheumatoid arthritis
This study tests whether a lower dose (200 mg) of rituximab given every 6 months is effective for maintaining control of rheumatoid arthritis. It is for people who are already on rituximab maintenance therapy and have low to moderate disease activity.
StrasbourgAges 18 years+ - NCT06915701RecruitingPhase 2/Phase 3
Vitamin E for rheumatoid arthritis inflammation
This study tests whether adding vitamin E to standard rheumatoid arthritis treatment can reduce inflammation and disease activity. It is designed for women with early RA who are not getting enough vitamin E from their diet.
Guadalajara, JaliscoAges 18 years+ - NCT06933134Recruiting
Using a biomarker to guide low-dose rituximab in rheumatoid arthritis
This trial aims to find out if a simple blood test (biomarker) can show whether a lower dose of rituximab will work for people with rheumatoid arthritis. If successful, it could help patients maintain good results with less medicine and fewer side effects.
ToursAges 18 years+ - NCT06946199RecruitingPhase 1
Study of Cizutamig for Hard-to-Treat Rheumatoid Arthritis
This trial tests an experimental drug called cizutamig for people with rheumatoid arthritis that hasn't responded to other treatments. It aims to see if a new approach can help control the disease in patients who still have active inflammation despite trying other advanced therapies.
Wuhan, HubeiAges 18–75 - NCT06947746Recruiting
Studying stem cells for rheumatoid arthritis knee pain
This trial tests if stem cells can improve pain and swelling in the knee for people with rheumatoid arthritis that hasn't responded well to standard treatments. It's for those who still have significant knee symptoms despite taking medications.
ShanghaiAges 18–65 - NCT06994143RecruitingPhase 1
A study of CLN-978 for rheumatoid arthritis
This trial tests a new medicine called CLN-978, given as an injection under the skin, to see if it can help people with active rheumatoid arthritis who haven't improved enough with other treatments. CLN-978 works by targeting a specific immune cell to reduce inflammation.
ErlangenAges 18 years+ - NCT06998628RecruitingPhase 2
Pentoxifylline for rheumatoid arthritis inflammation
This study tests if pentoxifylline, a medicine typically used for circulation, can help reduce joint inflammation in people with rheumatoid arthritis who still have active symptoms despite taking standard DMARDs.
Damietta, Damietta GovernorateAges 18–70 - NCT07017686Recruiting
Reboot Study: Nerve stimulation for rheumatoid arthritis
This study tests a device that sends mild electrical pulses to the vagus nerve in the abdomen to treat rheumatoid arthritis. It is for people whose arthritis has not improved after trying multiple medications.
Fitzroy, VictoriaAges 18–75
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Common questions
- Are there clinical trials for rheumatoid arthritis?
- Yes. Clin2 currently lists 271 recruiting rheumatoid arthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rheumatoid arthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rheumatoid arthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.