Clinical trials
Rheumatoid arthritis clinical trials
An autoimmune condition that causes painful swelling in the joints. We’re tracking 262 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06994143RecruitingPhase 1
A study of CLN-978 for rheumatoid arthritis
This trial tests a new medicine called CLN-978, given as an injection under the skin, to see if it can help people with active rheumatoid arthritis who haven't improved enough with other treatments. CLN-978 works by targeting a specific immune cell to reduce inflammation.
ErlangenAges 18 years+ - NCT06998628RecruitingPhase 2
Pentoxifylline for rheumatoid arthritis inflammation
This study tests if pentoxifylline, a medicine typically used for circulation, can help reduce joint inflammation in people with rheumatoid arthritis who still have active symptoms despite taking standard DMARDs.
Damietta, Damietta GovernorateAges 18–70 - NCT06972446RecruitingPhase 2
Targeted therapies for rheumatoid arthritis
This study tests different targeted treatments for adults with rheumatoid arthritis who have already tried other biologic or targeted medications and need a new option. It aims to find which treatment works best for people like you.
Peoria, ArizonaAges 18 years+ - NCT06946199RecruitingPhase 1
Study of Cizutamig for Hard-to-Treat Rheumatoid Arthritis
This trial tests an experimental drug called cizutamig for people with rheumatoid arthritis that hasn't responded to other treatments. It aims to see if a new approach can help control the disease in patients who still have active inflammation despite trying other advanced therapies.
Wuhan, HubeiAges 18–75 - NCT06947746Recruiting
Studying stem cells for rheumatoid arthritis knee pain
This trial tests if stem cells can improve pain and swelling in the knee for people with rheumatoid arthritis that hasn't responded well to standard treatments. It's for those who still have significant knee symptoms despite taking medications.
ShanghaiAges 18–65 - NCT06933134Recruiting
Using a biomarker to guide low-dose rituximab in rheumatoid arthritis
This trial aims to find out if a simple blood test (biomarker) can show whether a lower dose of rituximab will work for people with rheumatoid arthritis. If successful, it could help patients maintain good results with less medicine and fewer side effects.
ToursAges 18 years+ - NCT06915701RecruitingPhase 2/Phase 3
Vitamin E for rheumatoid arthritis inflammation
This study tests whether adding vitamin E to standard rheumatoid arthritis treatment can reduce inflammation and disease activity. It is designed for women with early RA who are not getting enough vitamin E from their diet.
Guadalajara, JaliscoAges 18 years+ - NCT06906549RecruitingPhase 4
Testing a lower dose of rituximab every 6 months for rheumatoid arthritis
This study tests whether a lower dose (200 mg) of rituximab given every 6 months is effective for maintaining control of rheumatoid arthritis. It is for people who are already on rituximab maintenance therapy and have low to moderate disease activity.
StrasbourgAges 18 years+ - NCT06876064Recruiting
Tracking people at risk for rheumatoid arthritis
This study follows different groups of people—from those at high risk of developing rheumatoid arthritis to those recently diagnosed—to learn more about the disease. By joining, you help researchers understand who gets RA and why, which may lead to earlier detection and better care.
Montpellier, HéraultAges 18–80 - NCT06841562Recruiting
Home Exercise and Anti-inflammatory Program for Early RA
This study tests if a home-based exercise program, combined with anti-inflammatory strategies, can help people newly diagnosed with rheumatoid arthritis manage their symptoms and improve health. It's a remote program, so you can participate from home.
Durham, North CarolinaAges 18 years+ - NCT06831331Enrolling by invitation
Diet and nutrition for newly diagnosed rheumatoid arthritis
This study tests whether a special diet can help manage symptoms of newly diagnosed rheumatoid arthritis. It aims to see if eating certain foods can reduce inflammation and improve your overall health.
GothenburgAges 18–85 - NCT06812481Recruiting
Anticholinergic drugs and bone health in rheumatoid arthritis
This study looks at whether a type of medication (anticholinergic drugs) used for other conditions affects bone health in people with rheumatoid arthritis. It will help doctors understand if these drugs increase the risk of osteoporosis (weak bones) and if they should be avoided.
BalıkesirAges 18 years+ - NCT05264025RecruitingPhase 1/Phase 2
Fexofenadine for active rheumatoid arthritis
This Phase 1/2 study tests whether fexofenadine (an allergy medicine) can improve symptoms and inflammation in people with active rheumatoid arthritis. Participants may be assigned to different treatment groups, and the study looks at safety and early signs of benefit.
Banī SuwayfAges 18–60 - NCT06726096Enrolling by invitationPhase 3
Trial of VDJ001 for moderate to severe rheumatoid arthritis
This trial tests a new medicine called VDJ001 for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. The goal is to see if VDJ001 helps reduce joint pain and swelling better than a placebo.
Beijing, Beijing MunicipalityAges 18–75 - NCT06718569Recruiting
Pain in Inflammatory Joint Diseases
This study looks at pain in people with inflammatory joint diseases. It aims to understand how pain changes when you start or switch to a newer type of arthritis medication.
OsloAges 18 years+ - NCT06671054RecruitingPhase 2
Testing AP1189 for newly diagnosed active rheumatoid arthritis
This study tests an oral drug called AP1189 for people just diagnosed with active rheumatoid arthritis who haven't yet taken standard arthritis medicines. You may be able to take part if your disease is very active and you're ready to try a new treatment option.
Cutler Bay, FloridaAges 18 years+ - NCT06649136RecruitingPhase 4
Optimizing methotrexate for active rheumatoid arthritis
This study tests whether increasing the dose of methotrexate or switching from pills to injections can better control rheumatoid arthritis symptoms. It aims to find the best way to use this common medication to reduce joint pain and swelling.
Vienna, State of ViennaAges 18–99 - NCT06628206RecruitingPhase 1
Testing LPX-TI641 for rheumatoid and psoriatic arthritis
This trial tests a new drug, LPX-TI641, to see if it is safe and how it works in the body for people with rheumatoid arthritis or psoriatic arthritis. It may be an option if you have active joint swelling and pain despite standard treatments.
AmmanAges 18 years+ - NCT06301373Recruiting
Combining methotrexate and tofacitinib for rheumatoid arthritis
This study tests whether combining two medicines—methotrexate and tofacitinib—works better for people with a specific type of rheumatoid arthritis. It may be a good fit if you have moderate to severe arthritis, have had a joint biopsy that shows a certain cell pattern, and haven't used similar treatments before.
Foshan, GuangdongAges 18–65 - NCT05428488RecruitingPhase 3
Step-by-step treatment for rheumatoid arthritis with TNF medicine
This trial tests a step-by-step plan for treating rheumatoid arthritis when current medicines aren’t controlling the disease. It compares how well a targeted approach works by adjusting treatment for people who need a TNF inhibitor.
Montpellier, FranceAges 18 years+ - NCT06201416RecruitingPhase 1
Single dose of SBT777101 for rheumatoid arthritis
This study tests a single dose of an experimental drug called SBT777101 for people with moderate to severe rheumatoid arthritis who have already tried and failed at least two advanced treatments. The goal is to see if it is safe and how the body handles it.
Scottsdale, ArizonaAges 18–70 - NCT05961592RecruitingPhase 1
Study drug R-2487 for people with active rheumatoid arthritis
This Phase 1 study tests how the drug R-2487 behaves in the body and looks at early safety in adults with active rheumatoid arthritis. If you have ongoing joint inflammation despite standard treatments, this trial may offer a chance to try an investigational therapy under close monitoring.
San Diego, CaliforniaAges 18–75 - NCT05782335Recruiting
Study immune cell changes with Orencia in rheumatoid arthritis
This trial studies how Orencia (abatacept) affects your immune system’s T and B cells in people with rheumatoid arthritis. It may help researchers better understand who responds to Orencia and what immune changes happen over time.
New York, New YorkAges 18 years+ - NCT04748809Recruiting
Diet trial for rheumatoid arthritis inflammation
This study tests whether an anti-inflammatory diet can help people with rheumatoid arthritis by lowering inflammation and disease activity. You may join if your symptoms are currently mild to moderate and you haven’t recently changed medications or your treatment plan.
La Jolla, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for rheumatoid arthritis?
- Yes. Clin2 currently lists 262 recruiting rheumatoid arthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rheumatoid arthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rheumatoid arthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.