Clinical trials
Sarcoma clinical trials
Below are recruiting sarcoma clinical trials, each written for real people, not researchers. We’re tracking 401 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03965234RecruitingPhase 1/Phase 2
Lung infusion for colorectal cancer that has spread to the lungs
This trial tests a procedure where chemotherapy is delivered directly into the lungs during surgery to remove or destroy lung tumors. It aims to reduce the chance of cancer returning after surgery for people with colorectal cancer that has spread to the lungs.
Buffalo, New YorkAges 18 years+ - NCT03016819RecruitingPhase 3
Test drugs anlotinib and catequentinib for advanced sarcoma
This Phase 3 study tests two anti-cancer medicines (anlotinib and catequentinib) for people with certain advanced soft-tissue sarcomas, including alveolar soft part sarcoma, synovial sarcoma, and leiomyosarcoma. It is designed for tumors that cannot be removed and that have either grown despite treatment or no longer respond to standard options.
Phoenix, ArizonaAges 18 years+ - NCT06074692RecruitingPhase 2
PARP inhibitor, SBRT, and immunotherapy for advanced sarcoma
This trial tests a combination of a PARP inhibitor drug, targeted radiation (SBRT), and immunotherapy for people with advanced sarcoma that has spread. It aims to see if this triple therapy can shrink tumors or slow the disease.
Shanghai, Shanghai MunicipalityAges 10–70 - NCT06637007RecruitingPhase 2
Chidamide plus AK112 for advanced sarcoma after first treatment
This trial tests two new drugs (chidamide and AK112) together for people with advanced bone or soft tissue sarcoma that has not responded to standard first-line treatment. The goal is to see if this combination can shrink tumors or slow their growth.
Taiyuan, ShanxiAges 18–75 - NCT07662239Recruiting
Exercise program for young sarcoma survivors
This study tests a personalized exercise service for teenagers and young adults who have had sarcoma. It aims to help you get active and stay healthy after treatment.
Boston, MassachusettsAges 15–39 - NCT03138161RecruitingPhase 1/Phase 2
Testing three medicines for previously treated soft-tissue sarcoma
This trial tests trabectedin plus ipilimumab and nivolumab in people with advanced soft-tissue sarcoma that has already been treated. It aims to see how well this combination works and how safely it can be given.
Santa Monica, CaliforniaAges 18 years+ - NCT04181970Recruiting
Study of sarcoma care quality across Europe and Latin America
This observational study looks at information from people with sarcoma to understand how care is delivered across different centers. It does not test a new treatment, but may help improve future care and planning.
Buenos AiresAges 18–120 - NCT07222735RecruitingPhase 1
CAR T cells and radiation for children with sarcoma
This trial tests a combination of targeted radiation and special immune cells (CAR T cells) for children and young adults whose bone or soft tissue sarcoma has come back or not responded to standard treatments. The CAR T cells are made from your own blood cells and are designed to attack a protein called B7-H3 found on the sarcoma cells.
Memphis, TennesseeAges Up to 21 years - NCT07071727Recruiting
Short course of radiation before surgery for soft tissue sarcoma
This trial tests whether a shorter course of radiation before surgery is effective for soft tissue sarcomas in certain locations. It aims to make treatment more convenient while maintaining good results.
AmsterdamAges 18 years+ - NCT06709495RecruitingPhase 1/Phase 2
PEEL-224 with chemo for teens and young adults with sarcoma
This trial tests a new drug called PEEL-224 combined with two chemotherapy drugs (vincristine and temozolomide) for people ages 12 to 49 with sarcoma that has come back or hasn't responded to standard treatments. The goal is to see if this combination is safe and effective.
Boston, MassachusettsAges 12–49 - NCT06674811Recruiting
Childhood cancer surgery recovery study
This study looks at how children and young adults recover after surgery for solid tumors. It also includes their caregivers to understand how resilience affects recovery.
Rochester, MinnesotaAges 3–25 - NCT06129903Recruiting
Early psychiatric help for people with sarcoma
This study tests if getting a psychiatric consultation soon after a sarcoma diagnosis can improve mental health and quality of life. If you have a new sarcoma and need surgery at MSK, you may be able to join.
Basking Ridge, New JerseyAges 18 years+ - NCT03099681Recruiting
Study of epithelioid sarcoma care and follow-up
This is an observational study for people diagnosed with epithelioid sarcoma, focused on how patients are followed over time. It does not appear to test a new treatment, but it can help doctors better understand the disease and follow-up needs.
Meldola, FCAges Any age - NCT05734066RecruitingPhase 1/Phase 2
Lurbinectedin drug study for young people with Ewing sarcoma
This trial tests lurbinectedin, a cancer medicine, by itself (no other drugs) in children and young adults whose Ewing sarcoma has come back or did not respond to prior treatment. It aims to see how safe the drug is and whether it can help control the cancer.
Los Angeles, CaliforniaAges 2–30 - NCT04845893Recruiting
Study of Ewing and related bone cancers
This is an observational study that follows people with Ewing’s sarcoma of the bone and certain “Ewing-like” tumors. It helps doctors understand the extent of disease at diagnosis and track outcomes, which may guide better planning for future care.
Rozzano, MIAges birth–49 years - NCT04749446Recruiting
Study of outcomes in breast sarcoma patients
This study looks at the medical details and outcomes of people with breast sarcoma. It may help doctors better understand what treatments and factors are linked to different results over time.
Bologna, BOAges 19 years+ - NCT04332874RecruitingPhase 2
Pembrolizumab with local limb chemotherapy for sarcoma in arms or legs
This trial tests whether giving pembrolizumab along with chemotherapy delivered directly into an arm or leg (isolated limb infusion) can shrink sarcoma tumors. It is for people with advanced or metastatic sarcoma in an arm or leg who can safely have this local treatment.
Basking Ridge, New JerseyAges 12 years+ - NCT04199026Recruiting
Tiny implanted device delivers drugs to sarcoma tumors
This trial tests an implantable device placed during planned surgery to deliver cancer medicines directly to sarcoma tumors and study how they affect the tumors. It may be an option if your sarcoma has come back or spread and surgery is part of standard care.
Houston, TexasAges 10 years+ - NCT04055220Recruiting
Regorafenib to keep bone cancer from coming back
This trial studies whether regorafenib given after first treatment helps patients with bone sarcoma stay in remission longer. It focuses on safety and whether the medicine can prevent the cancer from growing or returning.
BesançonAges 12 years+ - NCT04122872Recruiting
German sarcoma registry for adults with rare tumor types
This study is a German “registry,” meaning it collects information about people with specific bone or soft tissue tumors (including some borderline or hard-to-classify cases). It helps doctors and researchers learn more about these rare conditions to improve future care.
Tübingen, Baden-WurttembergAges 18 years+ - NCT03442465Recruiting
Study of healing and function after bone reconstruction surgery
This study looks at how well people heal and how well they can move and use the repaired bone after reconstructive surgery for bone tumors. It may help doctors understand what recovery looks like and what could improve function over time.
Basking Ridge, New JerseyAges 4 years+ - NCT02275286RecruitingPhase 1/Phase 2
Trabectedin plus radiation for select soft tissue sarcomas
This trial studies whether adding a chemotherapy medicine called trabectedin to targeted radiation can help control certain soft tissue sarcomas. It focuses on specific cancer types and locations, aiming to shrink tumors while keeping radiation safe for nearby healthy organs.
BordeauxAges 18 years+ - NCT05961761RecruitingPhase 2
Testing propranolol plus pembrolizumab for advanced sarcoma
This Phase 2 trial tests whether combining propranolol (a blood-pressure/heart medicine) with pembrolizumab (an immune therapy) can help people with advanced angiosarcoma or undifferentiated pleomorphic sarcoma that has progressed after first-line chemotherapy. It aims to slow tumor growth and improve outcomes while also studying tumor markers from your biopsy tissue.
AarhusAges 18 years+ - NCT04300257Recruiting
Prediction tool for choosing treatment in sarcoma care
This trial tests a way to use patient information to help doctors decide which treatment approach may fit best for people with certain bone or soft-tissue tumors. It may help improve selection and care planning, but it depends on whether your data can be used.
Winterthur, Canton of ZurichAges Any age
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Common questions
- Are there clinical trials for sarcoma?
- Yes. Clin2 currently lists 401 recruiting sarcoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sarcoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sarcoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.