Clinical trials
Severe Mental Disorder clinical trials
Below are recruiting severe mental disorder clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06601140Recruiting
Testing a smartphone app for tracking depression symptoms
This study tests a smartphone-based emotional monitoring device (EMOCARE) to see if it can accurately measure your mood compared to a standard depression questionnaire. It may help researchers find a simpler way to track depression symptoms.
AgenAges 18 years+ - NCT06967857RecruitingPhase 2
Dexamfetamine for adults with ADHD and depression
This trial tests a study medication (dexamfetamine) for adults who have both ADHD and moderate to severe depression. It aims to see if the medication is safe and helps improve both conditions.
BerlinAges 18–65 - NCT07227545Recruiting
Brain stimulation study for alcohol use disorder
This study tests a non-invasive brain stimulation treatment (using a mild electrical current) to see if it can help people reduce their alcohol use. It aims to improve symptoms of alcohol use disorder, which may help with recovery.
ShanghaiAges 18–60 - NCT05765864Recruiting
Study of self-harm in at-risk teens
This study looks at self-harm and thoughts/behaviors related to safety in teenagers who are considered at higher risk. It may help researchers better understand what supports are needed for teens who self-harm without wanting to die.
LjubljanaAges 13–18 - NCT06214065Recruiting
Brain stimulation for social thinking in autism
This trial tests whether mild brain stimulation (TMS) over the temporoparietal junction can improve a social thinking skill called 'mentalizing' in adults with autism. You would have MRI scans, cognitive tasks, and several TMS sessions.
Hartford, ConnecticutAges 18–35 - NCT07369752Recruiting
Breathing exercises for teens with depression or anxiety
This study looks at whether breathing exercises can help improve brain health and mental well-being in teens with depression or anxiety. It is designed for adolescents who are already receiving care at a Mayo Clinic psychiatry clinic.
Albert Lea, MinnesotaAges 12–17 - NCT06493825Recruiting
Mindfulness app for kids with severe tinnitus or misophonia
This trial tests whether a virtual reality mindfulness app can help children aged 10–18 with severe tinnitus or misophonia feel better mentally. It compares the mindfulness app to a placebo (sham) version.
Aurora, ColoradoAges 10–18 - NCT06462196Recruiting
Study of Depression, Bipolar Disorder & Suicide Risk
This study looks at how depression, bipolar disorder, and suicide risk naturally change over time. It aims to better understand these conditions so doctors can improve treatments.
Bethesda, MarylandAges 18–120 - NCT02531893Recruiting
Therapy for youth with severe, frequent irritability
This study tests whether two structured therapies can reduce severe irritability and angry reactions in children and teens. It focuses on youth who have had long-lasting, frequent outbursts and trouble responding to negative emotions.
Bethesda, MarylandAges 8–17 - NCT07566468Recruiting
Brain rhythm study for youth with ADHD or OCD
This study uses MRI and EEG to understand brain activity related to attention and impulse control in teens with ADHD or OCD. It may help researchers develop better treatments.
Bethesda, MarylandAges 10–17 - NCT06373484Recruiting
Matching treatment for kids with disruptive behavior and their parents
This study aims to find the best treatment approach for children with disruptive behavior by matching them to either group or individual therapy. It could help if your child struggles with behavior like defiance or conduct issues, and you're willing to participate in treatment.
Toronto, OntarioAges 6–12 - NCT07228182Recruiting
Brain stimulation study for gambling disorder
This trial tests a non-invasive brain stimulation method called high-intensity transcranial alternating current stimulation to see if it can reduce gambling urges and behavior in people with gambling disorder.
ShanghaiAges 18–60 - NCT05627492Recruiting
DBT booster sessions for youth at bipolar risk
This study adds short “booster” sessions to Dialectical Behavior Therapy (DBT) for young people who already took part in a prior DBT study, including those with bipolar symptoms or strong family risk. It aims to see if extra DBT support helps mood and coping over time.
Toronto, OntarioAges 14–25 - NCT05153382Recruiting
Dialectical behavior therapy for youth at bipolar risk
This trial tests whether a structured therapy called dialectical behavior therapy (DBT) helps young people with bipolar disorder or at risk for it, especially with self-harm or risky behaviors. It may help by teaching coping skills and improving safety and emotional control.
Toronto, OntarioAges 13–23 - NCT07411222Recruiting
Emotional Eating, Sleep, and Metabolic Health Study
This study examines how emotional eating, sleep quality, and mental state relate to metabolic syndrome (a group of conditions like high blood pressure, high blood sugar, and extra belly fat) in people with stable schizophrenia or bipolar disorder. It aims to help understand and improve overall health.
Bolu, BoluAges 18–65 - NCT07305688Recruiting
Climate anxiety and suicide risk in young people
This study explores how climate anxiety affects young people who are at risk for suicide. It aims to better understand the link between worries about climate change and suicidal thoughts or behaviors.
LimogesAges 16–24 - NCT04798274Recruiting
Brain wiring study in autism using safe hearing tasks
This study looks at how a brain chemical related to calming signals (“GABA”) may affect how people process sounds in autism. The goal is to understand brain function during hearing tasks, which could help guide future treatments.
Bethesda, MarylandAges 11–25 - NCT07113652Recruiting
Brain stimulation for obsessive-compulsive disorder
This trial tests a new type of noninvasive brain stimulation called temporal interference stimulation for people with OCD. It may help reduce symptoms when standard medications have not worked well enough.
Shanghai, Shanghai MunicipalityAges 18–50 - NCT05973110Recruiting
Virtual reality training to improve thinking in psychosis
This trial tests whether a virtual reality program can help people living with psychosis improve thinking and daily functioning. It may help if your symptoms are currently stable and you can safely use the VR equipment.
Ottawa, OntarioAges 18–60 - NCT07644338Recruiting
Brain Stimulation for Post-Traumatic Stress Disorder
This study tests a new non-invasive brain stimulation technique called temporal interference stimulation to help reduce PTSD symptoms. If you have PTSD that's lasted at least 3 months, this trial may help you or contribute to better treatments for others.
ShanghaiAges 18–50 - NCT06348992Recruiting
Talk therapy and yoga for burnout in parents of children with autism
This study tests if combining talk therapy (ACT) with gentle yoga can help parents of children with autism who feel burned out. If you often feel exhausted or overwhelmed by caregiving, this program may give you new coping skills and support.
Daqing, None SelectedAges Any age - NCT06528938Recruiting
Accelerated vs. standard TMS for teen depression
This study tests whether a faster, brain-guided form of TMS (called iTBS) can help treat depression in teenagers better than standard TMS. You may qualify if you're 16–19, have tried an antidepressant that didn't work well, and have no medical reasons to avoid TMS or MRI.
Ottawa, OntarioAges 16–19 - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT07342907Recruiting
Internal Family Systems therapy for borderline personality disorder
This study tests a type of talk therapy called Internal Family Systems (IFS) to see if it helps people with borderline personality disorder (BPD). You would attend 50 therapy sessions over about 12-15 months to explore how this approach may improve your symptoms and well-being.
Tiny, OntarioAges 18 years+
Hear when a new Severe Mental Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for severe mental disorder?
- Yes. Clin2 currently lists 164 recruiting severe mental disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.