Clinical trials
Severe Mental Disorder clinical trials
Below are recruiting severe mental disorder clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06208358Recruiting
Testing brain stimulation for gaming disorder
This study tests if a gentle brain stimulation technique (tACS) can help people with severe gaming disorder by improving how they interact with others. It aims to understand and treat the social challenges linked to the condition.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT07417813Recruiting
Lemborexant for insomnia in people with mental health conditions
This study tests if lemborexant, a sleep medication, can help people with both a mental health condition and insomnia. You would take the medicine as prescribed and complete questionnaires over 2 months.
Suzhou, JiangsuAges 18 years+ - NCT05538910Recruiting
Brain imaging study on substance use and depression
This study uses brain scans to understand how substance use and mental illness, like depression, are linked. It may help develop better treatments by looking at brain activity in people with and without depression.
Baltimore, MarylandAges 18–60 - NCT07667686Recruiting
French version of recovery survey for psychiatric patients
This study tests a French version of a questionnaire called the Recovery Assessment Scale. It asks about your personal experience of recovery while receiving psychiatric care. Your answers may help improve mental health services.
Jury, MoselleAges 18 years+ - NCT06942494Recruiting
CBT Self-Help for Teens with OCD (Family-Based)
This study tests a family-based cognitive behavioral therapy (CBT) self-help program for teens with OCD. It's designed to help you and a parent work together to manage OCD symptoms at home.
Xuhui, Shanghai MunicipalityAges 10–17 - NCT07499440RecruitingPhase 2
Testing a new medicine, HB-1, for PTSD
This trial tests an experimental medicine, HB-1, as a potential treatment for PTSD. It is a 8-week study to see if the medicine is safe and if it reduces PTSD symptoms. You must have a stable medication routine and be willing to take the study pill daily.
Deakin, Australian Capital TerritoryAges 18–65 - NCT06869863RecruitingPhase 1/Phase 2
Study of MediReg® for severe male infertility
This study tests an experimental medicine called MediReg® for men with severe infertility who have not been able to conceive. It aims to see if the drug is safe and can improve sperm quality, possibly offering a new option for men who have not had success with other treatments.
Moscow, MoscowAges 21–60 - NCT07106879Recruiting
Pre-screening for future metabolic and psychiatric studies
This study does not test a new treatment. It is a pre-screening program to see if you might qualify for future clinical trials on metabolic conditions (like diabetes or weight issues) or psychiatric health (like depression or anxiety). You will be asked some questions and may do some basic health checks to see which future trials could be a good fit for you.
Brooklyn, New YorkAges 18 years+ - NCT06978803Recruiting
Speech and brain study for early psychosis
This study looks at how people with early psychosis (within the first 5 years of treatment) talk during conversations. Researchers hope to learn more about speech patterns and brain activity related to psychosis.
Montreal, QuebecAges 18–60 - NCT04159662Recruiting
Brain scans to study thinking in schizophrenia and depression
This study uses brain imaging to better understand how thinking works in people with schizophrenia or major depression. Your results may help researchers learn what brain patterns match different thinking and symptoms.
Ottawa, OntarioAges 18–60 - NCT00025935Recruiting
Brain function study in children with mood problems
This study looks at how the brain works and how mood disorders change over time in children and teens with severe irritability, anger, and temper outbursts. It includes brain scans and regular check-ins to understand the illness better.
Bethesda, MarylandAges 7–85 - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT07031544Recruiting
Deep brain stimulation for severe OCD
This study tests whether implanting a small device deep in the brain—like a pacemaker for OCD—can help people whose severe OCD hasn't gotten better with standard medications and therapy.
Guangzhou, GuangdongAges 18–65 - NCT07640802Recruiting
Comparing talk therapies for irritability in children
This study compares two types of talk therapy for children who have frequent, intense irritability or temper outbursts. The goal is to see if a specific new therapy works better than a supportive, educational approach that does not include the active treatment techniques.
Bethesda, MarylandAges 8–17 - NCT04610697Recruiting
Cognitive training for people in forensic mental health care
This trial studies whether a structured “cognitive remediation” program (training thinking skills) can help people receiving care on a forensic treatment unit. It may benefit those who want support improving attention, memory, or problem-solving as part of their treatment.
Ottawa, OntarioAges 18–55 - NCT07764536Recruiting
Parent training plus a digital tool for child temper outbursts
This trial tests whether a digital tool can make parent training more effective for children who have frequent temper outbursts and irritability. The training helps parents learn skills to manage their child's behavior, and the digital tool may help them practice and apply those skills.
Bethesda, MarylandAges 8–13 - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT01392885Recruiting
Brain health and exercise program for schizophrenia
This trial studies how a structured exercise program may affect brain health in people with schizophrenia or schizoaffective disorder. It may help researchers understand whether exercise can support brain function and overall health in this condition.
Vancouver, British ColumbiaAges 19–45 - NCT03083405Enrolling by invitation
Study of tooth grinding during sleep
This study is for adults who have been diagnosed with sleep bruxism (tooth grinding during sleep). Researchers want to understand it better using sleep testing, and it may help refine how this condition is evaluated.
WroclawAges 18–70 - NCT07698925Recruiting
Breathing exercises for sleep problems in PCOS
This trial tests if simple diaphragmatic breathing exercises can improve sleep for women with Polycystic Ovarian Syndrome (PCOS) who have trouble sleeping. If you have PCOS and poor sleep, this gentle, non-drug approach might help.
Cairo, Cairo GovernorateAges 25–35 - NCT06792175Enrolling by invitation
Using speech to detect mental health conditions
This study uses a computer program to listen to your speech and see if it can help detect mental health or neurodevelopmental conditions. It may help find new ways to diagnose conditions like ADHD, anxiety, depression, and others earlier.
Brookline, MassachusettsAges 13–60 - NCT07198594Recruiting
Fast brain stimulation for hard-to-treat OCD
This study tests a fast-acting brain stimulation method (accelerated rTMS) for people whose obsessive-compulsive disorder has not improved enough with standard treatments. It aims to help those who still have moderate to severe symptoms despite trying multiple medications.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT04685148RecruitingPhase 1/Phase 2
Study of mental health treatment during pregnancy
This trial studies a treatment aimed at improving maternal mental health during pregnancy. It focuses on people who have had depression around pregnancy before, and checks whether the approach is safe and helpful for them.
CopenhagenAges 18–45 - NCT07459244Recruiting
ECG changes in people who use methamphetamine
This study looks at the electrical activity of the heart (ECG) in people who use methamphetamine, including those who develop psychosis from it. It compares them to healthy volunteers to see if methamphetamine affects heart function.
Elâzığ, ElâzığAges 18–65
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Common questions
- Are there clinical trials for severe mental disorder?
- Yes. Clin2 currently lists 164 recruiting severe mental disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.