Clinical trials
Severe Mental Disorder clinical trials
Below are recruiting severe mental disorder clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05859347Recruiting
Brain stimulation study for cannabis use disorder
This trial tests whether a treatment called repetitive transcranial magnetic stimulation (a non-surgical magnetic stimulation to the brain) can help people reduce or stop cannabis use. You may be eligible if you have cannabis use disorder and meet specific safety and symptom criteria.
Toronto, OntarioAges 18–65 - NCT07480668Recruiting
Aromatherapy for emotional wellness during IVF
This study tests whether inhaling lavender essential oil can help reduce anxiety, stress, and depression for women waiting for IVF. You may benefit if you are feeling some emotional distress and are not using other mind-body or herbal treatments.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT07408934Enrolling by invitation
Group therapy for feeling safer with psychosis
This trial tests a group therapy program called the Feeling Safe Programme for people with psychosis. It aims to help you learn new ways to cope with your symptoms and feel safer. It meets once a week for 75 minutes.
Ottawa, OntarioAges 18 years+ - NCT07334561Recruiting
Brain stimulation for depression and pain
This study tests a non-invasive brain stimulation treatment (transcranial electrical stimulation) for people who have both depression and chronic pain. It aims to see if this treatment can help improve mood and reduce pain.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06891300RecruitingPhase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Ottawa, OntarioAges 18–65 - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT07557017Recruiting
Emotional Disorder Treatment Study Using Unified Protocol
This study tests a structured therapy approach called the Unified Protocol, designed to treat multiple emotional disorders (like depression, anxiety, and OCD) with one flexible treatment. Researchers want to see if this approach helps people manage their symptoms over 14 weeks of outpatient therapy.
PragueAges 18 years+ - NCT06959342Recruiting
Brain stimulation to reduce cravings in alcohol use disorder
This trial tests if a gentle brain stimulation technique (tDCS) can help people with alcohol use disorder control their cravings and drinking habits. It is an add-on to your regular treatment.
MannheimAges 18–65 - NCT07484750Recruiting
Mindfulness group therapy for OCD
This trial tests a type of group therapy that combines mindfulness with exposure techniques to help people with obsessive-compulsive disorder (OCD) manage their symptoms. If you have OCD and are between 16 and 55 years old, you may be able to join.
Shanghai, Shanghai MunicipalityAges 16–55 - NCT05142683Recruiting
Test an integrated care plan for teens with depression
This study tests whether a structured, coordinated care pathway helps teens (and their caregivers) manage depression better than usual care. It aims to see if targeted treatment and follow-up improve depression symptoms over time.
Toronto, OntarioAges 13–18 - NCT06973512Recruiting
Brain stimulation for severe addiction
This trial tests a new brain stimulation approach for people with severe addiction that hasn't gotten better with other treatments. It uses deep brain stimulation guided by brain mapping to try to reduce cravings and help you stay abstinent.
Toronto, OntarioAges 25–65 - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT06417437RecruitingPhase 4
Brain-computer interface test for depression
This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.
Shanghai, Shanghai MunicipalityAges 12 years+ - NCT06951542Enrolling by invitation
Reducing HIV and mental health stigma in Malawi
This study tests a program to reduce stigma for people living with HIV who also have symptoms of depression. It aims to improve mental health and HIV outcomes.
MulanjeAges 18 years+ - NCT06152705Recruiting
fMRI-Guided vs. Standard Brain Stimulation for Depression
This study compares two types of repetitive transcranial magnetic stimulation (rTMS) to treat depression. One type uses a brain scan (fMRI) to guide the treatment, while the other uses a standard approach. It may help people whose depression hasn't improved with medication.
Ottawa, OntarioAges 18 years+ - NCT07146633Recruiting
Testing an EMDR app for PTSD and substance use
This study tests an app that uses EMDR therapy to help people with both PTSD and substance use problems. EMDR is a type of therapy that uses eye movements or taps to help process traumatic memories. You would use the app at home and avoid starting other new therapies during the study.
Toronto, OntarioAges 18 years+ - NCT07031661Recruiting
Bipolar disorder risk study for teens and children
This study follows children and teens who may be at higher risk for bipolar disorder to develop a prediction model. It includes three groups: those with a parent who has bipolar disorder, those with atypical depression, and healthy volunteers.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT06675461Enrolling by invitation
Brief talk therapy for suicidal patients with borderline personality disorder
This trial tests a short talk therapy for people with borderline personality disorder who come to the emergency department after hurting themselves or thinking about suicide. The goal is to see if this brief help can ease suicidal thoughts and keep you safer.
Toronto, OntarioAges 16 years+ - NCT06672588Recruiting
Magnetic seizure therapy for schizophrenia
This trial tests a new type of brain stimulation called magnetic seizure therapy (MST) for people with schizophrenia who haven't gotten better with standard medicines. The goal is to see if MST can help reduce symptoms like hallucinations or confusion.
Vancouver, British ColumbiaAges 18 years+ - NCT07573839Recruiting
Predicting bipolar disorder relapse using voice and video analysis
This study uses artificial intelligence to analyze speech patterns and facial expressions from people with bipolar disorder to predict who might have a relapse. If successful, it could help doctors identify warning signs earlier and prevent episodes before they happen.
ShanghaiAges 18–64 - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT05608434RecruitingPhase 1/Phase 2
Virtual reality ADHD training for kids and teens
This study tests whether a virtual reality (VR) training program can help strengthen attention and focus in children and teens with ADHD. Participants will use a VR headset for training sessions, and the study will compare different groups to see how well the training works.
Bethesda, MarylandAges 8–16 - NCT05153369Recruiting
DBT-based care for youth at risk for bipolar disorder
This study tests a structured, “DBT-informed” care program for young people who either have bipolar disorder or are at family risk for it. It may help by offering closer, organized support aimed at preventing or reducing mood problems.
Toronto, OntarioAges 13–23 - NCT05427500Enrolling by invitationPhase 3
Nerve block treatment for PTSD with strong stress-and-alertness symptoms
This Phase 3 study tests whether a procedure called a stellate ganglion block can reduce PTSD symptoms, especially feeling highly “on edge” (hyperarousal). You may join if you have PTSD despite appropriate usual treatments and are able to go through the procedure safely.
Ottawa, OntarioAges 18–69
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Common questions
- Are there clinical trials for severe mental disorder?
- Yes. Clin2 currently lists 164 recruiting severe mental disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.