Clinical trials
Sickle Cell clinical trials
Below are recruiting sickle cell clinical trials, each written for real people, not researchers. We’re tracking 171 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07064174Recruiting
Sickle cell kidney research study
This study collects kidney tissue samples from people with sickle cell disease and healthy volunteers to better understand how sickle cell affects the kidneys. If you have sickle cell disease or a related blood disorder, you may help researchers find new ways to protect kidney function.
Dallas, TexasAges 18–65 - NCT04774536RecruitingPhase 1/Phase 2
CRISPR gene-edited bone marrow transplant for severe sickle cell
This Phase 1/2 study tests a CRISPR-edited bone marrow (stem cell) transplant to treat severe sickle cell disease. It aims to reduce dangerous sickle-related complications by changing the patient’s stem cells before transplant.
Los Angeles, CaliforniaAges 12–35 - NCT07356050Recruiting
Measles vaccine study for children with sickle cell disease
This study checks if the measles vaccine works well in children with sickle cell disease. It aims to help protect children with this condition from measles.
Cincinnati, OhioAges 6 months–6 years - NCT07316478Recruiting
Stress Management and Mindfulness for Sickle Cell Disease
This study tests a stress management and mindfulness program designed to help people with sickle cell disease cope better. It aims to see if these techniques can reduce pain and improve your quality of life.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07282210RecruitingPhase 2
New medicine for sickle cell hemolysis
This trial tests a new medicine (SIL-8301) to help control red blood cell breakdown (hemolysis) in people with sickle cell disease. It is for those who are already taking hydroxyurea and have had few pain crises but still have complications from hemolysis.
Toronto, OntarioAges 16–35 - NCT07252050RecruitingPhase 1/Phase 2
Ruxolitinib and half-matched transplant for severe sickle cell disease
This trial tests a new approach using the drug ruxolitinib to help a half-matched bone marrow transplant work better for people with severe sickle cell disease. It aims to reduce complications and improve outcomes.
Aurora, ColoradoAges 12–45 - NCT07246265Recruiting
Morphine clearance study for sickle cell crisis in ICU
This study looks at how the body clears morphine in adults with sickle cell disease who are in the intensive care unit (ICU) for a pain crisis or acute chest syndrome and are receiving morphine through a patient-controlled analgesia (PCA) pump. The goal is to understand how kidney function affects morphine breakdown.
Tours, FranceAges 18 years+ - NCT06506461RecruitingPhase 1
Gene editing for sickle cell disease in young adults
This trial uses gene editing to fix your own blood stem cells, so you can stop having severe sickle cell crises. It is for young adults with frequent pain episodes or who need regular blood transfusions.
Memphis, TennesseeAges 18–24 - NCT03279094RecruitingPhase 1
Testing a half-matched bone marrow transplant for sickle cell
This early-phase study tests whether a “half-matched” donor bone marrow transplant, with special medicines to calm the immune system before transplant, can improve outcomes for people with sickle cell disease. It may help high-risk patients who have frequent complications and don’t have a fully matched donor.
Duarte, CaliforniaAges 1–30 - NCT07083531Recruiting
Bone health study for older Black women with sickle cell trait
This study looks at how carrying the sickle cell trait (not the disease) affects bone density, physical function, and frailty in older African American women. It aims to help understand bone loss risk and prevent fractures.
Farmington, ConnecticutAges 50 years+ - NCT07001189Recruiting
Numbing for sickle cell pain crisis: a study
This trial tests whether numbing a specific area (regional anesthesia) can reduce inflammation and pain during a sickle cell pain crisis. It may offer a new way to manage severe pain without strong medications.
Pointe-à-PitreAges 18 years+ - NCT07610239Recruiting
Newborn Sickle Cell Disease Screening System in Uganda
This study tests a new computer system to help hospitals quickly identify babies with sickle cell disease (an inherited blood disorder) right after birth or at early health visits. Finding sickle cell disease early helps prevent serious health problems and saves lives.
JinjaAges 18 years+ - NCT06941389Recruiting
Comparing stem cell transplant vs standard therapy for sickle cell disease
This study compares two treatment approaches for children with sickle cell anemia: a stem cell transplant from a matched family donor versus continuing regular disease-modifying medicines. It aims to see which treatment works better over time.
Birmingham, AlabamaAges 3–20 - NCT06665997RecruitingPhase 4
Depot shot for pain in women with sickle cell disease
This study tests if a hormone shot (depot medroxyprogesterone acetate) can help reduce pain episodes in women with sickle cell disease. It aims to see if the shot improves pain and markers of inflammation.
Atlanta, GeorgiaAges 18–50 - NCT06647979RecruitingPhase 1
Gene editing for severe sickle cell or thalassemia
This trial tests a new gene therapy that edits your own blood stem cells to help them make more fetal hemoglobin, which can prevent sickling and reduce the need for transfusions. It is for people with severe sickle cell disease or beta thalassemia who do not have a matched sibling donor.
Boston, MassachusettsAges 13–40 - NCT06399107RecruitingPhase 1/Phase 2
Gene therapy trial for sickle cell disease using BAH243
This trial tests a gene therapy that uses a modified virus to deliver a healthy gene to your blood stem cells. It aims to help people with sickle cell disease produce normal red blood cells and reduce painful crises.
Beijing, Beijing MunicipalityAges 2–90 - NCT06184126Recruiting
Virtual reality for sickle cell pain in the emergency room
This trial tests whether using a virtual reality (VR) headset, along with your usual pain treatment, can help reduce pain during a sickle cell crisis. It is for adults with sickle cell disease who are in the emergency department and receiving IV opioids for a vaso-occlusive crisis.
Baltimore, MarylandAges 18 years+ - NCT06071377Recruiting
Learning About Health in People With Sickle Cell Trait
This study is for adults who have or might have sickle cell trait (carrying the sickle cell gene but not the disease). It aims to understand the health effects of sickle cell trait over time by following participants and collecting health information.
Birmingham, AlabamaAges 18 years+ - NCT04819841RecruitingPhase 1/Phase 2
Gene correction using your own stem cells to improve sickle disease
This trial tests a gene-correction treatment that changes sickle hemoglobin (HbS) into normal hemoglobin (HbA) using your own stem cells. It may help reduce severe sickle cell complications for people with severe disease who meet specific safety and medical criteria.
Los Angeles, CaliforniaAges 12–50 - NCT06016634RecruitingPhase 2
Alendronate for bone damage in adults with sickle cell disease
This trial tests if the drug alendronate can help heal bone damage caused by sickle cell disease. It may be an option if you have this bone problem and are between 18 and 80 years old.
Sacramento, CaliforniaAges 18–80 - NCT05904093RecruitingPhase 1
Testing a new pill for sickle cell disease safety
This study tests a medication called fostamatinib to see if it is safe and tolerable for people with sickle cell disease. It may offer a new treatment option for managing the condition.
Bethesda, MarylandAges 18–65 - NCT03121001RecruitingPhase 2
Transplant from a half-matched donor for aggressive sickle cell
This Phase 2 study tests a “half-matched” stem cell transplant to treat people with aggressive sickle cell disease. It may help by replacing the blood system using stem cells from a related donor who is close but not fully matched.
Chicago, IllinoisAges 16–60 - NCT05477563RecruitingPhase 3
One-time gene therapy for severe sickle cell and transfusion anemia
This trial tests a single dose of gene therapy (CTX001) to improve outcomes for people with severe sickle cell disease or transfusion-dependent beta-thalassemia. It aims to see how well it works and whether it is safe, especially after a planned stem cell transplant process.
New York, New YorkAges 12–35 - NCT05392894RecruitingPhase 3
Transplant using a half-matched donor for severe sickle cell
This trial tests whether a half-matched (haploidentical) blood stem cell transplant can treat adults with severe sickle cell disease. It may help reduce serious complications and improve survival, but it requires a fit health status and specific donor and medical conditions.
LondonAges 18 years+
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Common questions
- Are there clinical trials for sickle cell?
- Yes. Clin2 currently lists 171 recruiting sickle cell studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sickle cell trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sickle cell trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.