Clinical trials
Sickle Cell clinical trials
Below are recruiting sickle cell clinical trials, each written for real people, not researchers. We’re tracking 179 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04819841RecruitingPhase 1/Phase 2
Gene correction using your own stem cells to improve sickle disease
This trial tests a gene-correction treatment that changes sickle hemoglobin (HbS) into normal hemoglobin (HbA) using your own stem cells. It may help reduce severe sickle cell complications for people with severe disease who meet specific safety and medical criteria.
Los Angeles, CaliforniaAges 12–50 - NCT07252050RecruitingPhase 1/Phase 2
Ruxolitinib and half-matched transplant for severe sickle cell disease
This trial tests a new approach using the drug ruxolitinib to help a half-matched bone marrow transplant work better for people with severe sickle cell disease. It aims to reduce complications and improve outcomes.
Aurora, ColoradoAges 12–45 - NCT07316478Recruiting
Stress Management and Mindfulness for Sickle Cell Disease
This study tests a stress management and mindfulness program designed to help people with sickle cell disease cope better. It aims to see if these techniques can reduce pain and improve your quality of life.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07356050Recruiting
Measles vaccine study for children with sickle cell disease
This study checks if the measles vaccine works well in children with sickle cell disease. It aims to help protect children with this condition from measles.
Cincinnati, OhioAges 6 months–6 years - NCT00542230Recruiting
Blood sample study for sickle cell trait and controls
This study collects blood samples to learn more about sickle cell-related genetics and biology. You might benefit indirectly by helping researchers understand the condition, even though this is laboratory research rather than a medication trial.
Bethesda, MarylandAges 18–100 - NCT07488091Recruiting
Sickle cell pregnancy care program in Ghana
This trial tests a team-based care program for pregnant women with sickle cell disease. It aims to improve health for both mothers and babies through regular checkups and support.
AccraAges 18–45 - NCT07610239Recruiting
Newborn Sickle Cell Disease Screening System in Uganda
This study tests a new computer system to help hospitals quickly identify babies with sickle cell disease (an inherited blood disorder) right after birth or at early health visits. Finding sickle cell disease early helps prevent serious health problems and saves lives.
JinjaAges 18 years+ - NCT06612268RecruitingPhase 3
Testing etavopivat for sickle cell disease
This study tests an experimental pill called etavopivat for people with sickle cell disease who have had some pain crises in the past year. The goal is to see if it reduces these crisis episodes.
Birmingham, AlabamaAges 12 years+ - NCT07566494RecruitingPhase 1
Testing VAS-101 for sickle cell disease
This early-phase trial tests a new drug called VAS-101 for people with sickle cell disease. It aims to find a safe dose and see how the drug affects the body.
Bethesda, MarylandAges 18–90 - NCT02447874RecruitingPhase 1/Phase 2
Arginine treatment for children’s sickle cell pain
This early-phase study tests whether arginine can help control pain in children with sickle cell disease. You may be considered if your child is having a sickle cell pain episode that needs stronger pain medicine given through an IV.
Atlanta, GeorgiaAges 7–21 - NCT02675959RecruitingPhase 2
Transplant with defibrotide for sickle cell disease
This trial tests a stem cell transplant from a half-matched donor using a strong conditioning regimen and a drug called defibrotide to protect organs. It aims to cure sickle cell disease in patients who have had serious complications like stroke, chest syndrome, or frequent pain episodes.
Los Angeles, CaliforniaAges 6 months–21 years - NCT06546670RecruitingPhase 1/Phase 2
Study of ITU512 for sickle cell disease
This trial tests a new medicine called ITU512 in two groups: healthy volunteers and people with sickle cell disease. In the second part, researchers want to see if ITU512 can help manage sickle cell disease.
Birmingham, AlabamaAges 12–55 - NCT05377372Recruiting
Study of early exposures in babies with sickle cell disease
This study asks mothers of babies with sickle cell disease about early-life exposures and related factors. It may help researchers understand what might affect health in the first months of life.
Birmingham, AlabamaAges 18–50 - NCT03214354RecruitingPhase 2
Stem cell transplant for children with sickle cell and ABO mismatch
This trial studies a stem cell transplant approach for children with sickle cell disease, using a sibling donor whose blood type is not compatible. It aims to see if this transplant method can safely reduce serious sickle cell complications.
Calgary, AlbertaAges 1–19 - NCT03353584Recruiting
Virtual reality for pain relief during sickle cell pain crises
This trial tests whether a virtual reality (VR) experience can help reduce pain during a sickle cell “vaso-occlusive crisis,” which is an episode of sudden, severe pain. It’s offered alongside the care team’s usual pain management to see if VR makes pain feel better.
Memphis, TennesseeAges 6–25 - NCT03587272RecruitingPhase 2
Sibling bone marrow transplant to reduce treatment side effects
This study tests a way to do a bone marrow (stem cell) transplant from an HLA-matched sibling in children with sickle cell disease, aiming to lower the risk of serious side effects. You may be considered if you have certain past sickle complications and your body can safely handle the transplant plan.
Washington D.C., District of ColumbiaAges 2–25 - NCT03786549Recruiting
Sickle cell care transition program for teens and families
This study tests a structured program to help teens with sickle cell disease smoothly transition from pediatric care to adult care, with support for parents or legal guardians. It may help families coordinate care sooner and more confidently during this change.
Fort-de-France-La Martinique, La MartiniqueAges 16–17 - NCT04055818RecruitingPhase 1
Testing three medicines for high-risk sickle cell disease
This Phase 1 study tests whether nicotinamide, oral tetrahydrouridine, and decitabine can help people with high-risk sickle cell disease. It is mainly a safety-and-dosing study, but it also looks for signs the medicines may improve disease-related problems.
Chicago, IllinoisAges 18 years+ - NCT04093986Recruiting
Using past pregnancy records from women with sickle cell
This study looks back at past pregnancy and breastfeeding experiences in women with sickle cell disease who took hydroxyurea. It aims to better understand how hydroxyurea exposure may affect pregnancy and baby outcomes.
Cincinnati, OhioAges Any age - NCT04109820Recruiting
Testing MitoQ for blood clotting activity in sickle cell
This trial studies whether MitoQ changes how your platelets (blood cells that help clot) work and how much “reactive oxygen” your body makes. It includes adults with sickle cell anemia and African American healthy volunteers to compare results.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04166526Recruiting
Brain and brain-vessel MRI study in kids with sickle cell
This study uses MRI scans to understand how the brain and blood vessels are affected in children with sickle cell disease, including before and after certain treatments. It also includes healthy children for comparison and may help improve future monitoring and care.
Boston, MassachusettsAges 8–18 - NCT04484272Recruiting
Phone app for stress and pain self-management in sickle cell
This study tests whether an m-health (phone) app that teaches stress and pain self-management can help adults with sickle cell disease manage moderate to severe pain. You may be able to use the app alongside your usual care, especially if you’ve had significant pain recently.
Gainesville, FloridaAges 18–99 - NCT05099874Recruiting
Computer training to improve attention in sickle cell disease
This trial tests whether a computer-based “attention control” training program can improve attention and daily functioning in children with sickle cell disease. To join, you must meet certain criteria and also pass an initial attention screening test during the study.
Washington D.C., District of ColumbiaAges 8–16 - NCT05170412Recruiting
Diet habits study for adults with sickle cell disease
This study asks adults with sickle cell disease about what they eat and their eating routines. The goal is to understand diet patterns in sickle cell and how they may relate to health, which could help future care and guidance.
Bethesda, MarylandAges 18–120
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Common questions
- Are there clinical trials for sickle cell?
- Yes. Clin2 currently lists 179 recruiting sickle cell studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sickle cell trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sickle cell trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.