Clinical trials
Skin Cancer clinical trials
Below are recruiting skin cancer clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07010692RecruitingPhase 1/Phase 2
Treating skin cancers with laser and ointment
This trial tests a combination of fractional laser and tirbanibulin ointment to treat basal or squamous cell skin cancer that hasn't been treated before. It may offer a less invasive option for people with these common skin cancers.
New York, New YorkAges 18 years+ - NCT06998342RecruitingPhase 2
Mohs surgery plus short radiation for head and neck skin cancer
This trial studies a combination of Mohs surgery and a short course of radiation therapy for people with squamous cell skin cancer of the head and neck. The goal is to see if this approach is effective with fewer side effects.
Burlington, VermontAges 18 years+ - NCT05108090Recruiting
Sentinel node biopsy for head and neck skin cancer
This study checks whether a “sentinel lymph node biopsy” can help find if skin cancer in the head or neck has spread to nearby lymph nodes. It uses special dye/medicine and imaging, then removes the cancer and the sentinel node soon after scanning.
Indianapolis, IndianaAges 18 years+ - NCT05033678Recruiting
Teledermoscopy and AI help review your skin spot images
This study tests a way for doctors to send clear images of your skin spot to be reviewed remotely using teledermoscopy (digital images of the skin). It may help speed up specialist input and improve how skin spots are assessed.
LundAges 15 years+ - NCT06624644RecruitingPhase 2/Phase 3
LNS8801 with or without pembrolizumab for advanced melanoma
This trial tests a new drug called LNS8801, alone or with pembrolizumab, for people with advanced melanoma that has stopped responding to prior treatments, especially anti-PD-1 therapy.
Newport Beach, CaliforniaAges 18 years+ - NCT06615635Recruiting
Radiation device trial for skin cancer in patients with weak immune systems
This trial tests a special radiation device (DaRT) placed directly into skin cancer tumors. It is designed for patients with weakened immune systems (immunocompromised) who have a single skin cancer lesion on the skin (not spread elsewhere).
Gilbert, ArizonaAges 18 years+ - NCT06489301Recruiting
Laser treatment for skin rejuvenation during tummy tuck
This study tests a laser treatment to see if it can help rejuvenate skin taken during tummy tuck surgery. If you are having a tummy tuck and meet the requirements, you may be able to join.
Fairborn, OhioAges 18 years+ - NCT06428721Recruiting
Can laser treatment prevent skin spots in older adults?
This study tests if a laser treatment on your forearms can prevent precancerous spots (actinic keratoses) from developing in older adults with fair skin. You would receive the laser on one arm and a sham treatment on the other, and your skin will be monitored.
Fairborn, OhioAges 60 years+ - NCT06423573Recruiting
Skin cancer risk in epidermolysis bullosa patients using Filsuvez
This study tracks anyone with dystrophic or junctional epidermolysis bullosa who is using Filsuvez gel to see how often skin cancers appear. It is designed to understand the long-term safety of the treatment.
Palo Alto, CaliforniaAges Any age - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+ - NCT06057675RecruitingPhase 2
Tranexamic acid for nose reconstruction after Mohs surgery
This trial tests if tranexamic acid (a medicine that helps blood clot) reduces bleeding and bruising during nose reconstruction after skin cancer removal. It is for adults having a specific type of flap repair on their nose.
Nashville, TennesseeAges 18 years+ - NCT05955924RecruitingPhase 3
Nicotinamide to prevent skin cancer after organ transplant
This trial tests nicotinamide (a vitamin-like medicine) to help prevent new keratinocyte skin cancers in people who have had a kidney, liver, heart, or lung transplant. It may lower the chance of developing new skin tumors while you continue your usual transplant anti-rejection medicines.
Calgary, AlbertaAges 18 years+ - NCT05381597RecruitingPhase 2/Phase 3
Skin cream treatment for small early non-melanoma skin cancers
This study tests whether 5-fluorouracil and calcipotriene (medicines used on the skin) can treat certain small, early skin cancers or pre-cancers without surgery. It’s for specific types and locations of lesions and aims to see how well the treatment works and how safe it is.
Boston, MassachusettsAges 18 years+ - NCT03889899Recruiting
Device treatment for certain skin, mouth, or surface soft tissue cancers
This trial studies a radiation-emitting device (DaRT) to treat certain cancers on the skin, in the mouth, or in superficial soft tissues. You may qualify if you have a confirmed malignant tumor, enough body strength for treatment, and blood tests and pregnancy status that meet safety limits.
HaifaAges 18 years+ - NCT05779423RecruitingPhase 2
Freezing tumor plus two immunotherapies for advanced melanoma
This trial tests whether combining a local treatment that freezes a tumor (cryoablation) with two immune “checkpoint” medicines (ipilimumab and nivolumab) can better control unresectable melanoma. It may help when melanoma has grown after prior immune therapy.
Boston, MassachusettsAges 18 years+ - NCT05702398RecruitingEarly Phase 1
Vitamin A and niacinamide for high-risk skin cancer
This early trial tests whether adding vitamin A and niacinamide (a form of vitamin B3) can help people with a history of certain skin cancers reduce new disease. It is designed for adults with specific prior skin cancer or skin lesion treatment patterns.
Providence, Rhode IslandAges 18 years+ - NCT05047094Recruiting
DaRT radiation plus pembrolizumab for head and neck cancer
This trial tests whether a targeted internal radiation treatment (DaRT) combined with pembrolizumab (an immune therapy) can shrink recurrent or metastatic head and neck squamous cell cancer that cannot be fully removed with surgery. It may help by making cancer more visible to the immune system while delivering localized radiation to a tumor area.
JerusalemAges 18 years+ - NCT04534127Recruiting
DaRT radiation device for skin and mouth or superficial tumors
This trial tests a targeted radiation device (DaRT seeds) to treat certain cancers on the skin, in the mouth, or in superficial soft tissue. It may help when standard treatment (like surgery or regular radiation/chemo) hasn’t worked, isn’t safe, or isn’t wanted.
JerusalemAges 18 years+ - NCT04068155Recruiting
Radiation device for certain skin cancers you can treat locally
This trial tests a radiation-emitting device placed near the tumor to treat certain malignant skin cancers that can be fully covered. It may help shrink or control the cancer at the skin site where the device is applied.
GrenobleAges 18 years+ - NCT07478900Recruiting
Tattoo marking breast tumors before chemo
This trial tests a simple method: marking the tumor with a small tattoo before chemotherapy. The tattoo helps surgeons find the exact spot for lumpectomy after the tumor shrinks, so you can keep more of your breast.
Bhubaneswar, OdishaAges 18–75 - NCT06823414Recruiting
Robotic-assisted nipple-sparing mastectomy trial
This trial tests a robotic-assisted surgery technique for women who need a mastectomy but can keep their skin and nipple. It aims to improve outcomes for breast cancer patients and those at high risk.
A Coruña, GaliciaAges 18 years+ - NCT07545720RecruitingPhase 2
Pinoxin to prevent radiation skin damage
This study tests whether a protective agent called Pinoxin can prevent or reduce skin damage from radiation therapy. If you're getting radiation treatment for cancer, this trial may help protect your skin during therapy.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06837831Recruiting
Mepilex Lite Dressing for radiation skin damage on anal area
This trial tests a special wound dressing (Mepilex Lite) to treat skin burns from radiation therapy in patients with rectal cancer. It may help heal the skin around the anal canal more comfortably.
Jinan, ShandongAges 18 years+ - NCT07548762Recruiting
Skin-Sparing vs. Standard Mastectomy for Breast Cancer
This study compares two surgical approaches to remove breast cancer: one that preserves more of the skin (skin-sparing) versus a standard approach. The goal is to see which method results in fewer wound-healing problems after surgery.
Guangzhou, GuangdongAges 18–75
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Common questions
- Are there clinical trials for skin cancer?
- Yes. Clin2 currently lists 186 recruiting skin cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a skin cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a skin cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.