Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05188287Recruiting
Phone app support to help Black smokers quit
This study tests a culturally tailored smartphone app plus coaching to help African American adults quit smoking. You may qualify if you smoke daily, are ready to quit soon, and can use the quit supports they provide.
Oklahoma City, OklahomaAges 18 years+ - NCT05646485Recruiting
Bladder cancer screening for people at higher risk
This trial tests screening for bladder cancer in people who have higher risk due to age, smoking, and certain job exposures. It may help find bladder cancer earlier when treatment can be more effective.
Dallas, TexasAges 50 years+ - NCT05687604Recruiting
Telehealth program to reduce cancer risk behaviors
This trial offers a scalable telehealth (phone/video) program to help people improve cancer risk habits like low physical activity, higher body weight, and smoking. It may help by giving structured coaching and support in the privacy of your home.
Chicago, IllinoisAges 18 years+ - NCT07157813Enrolling by invitation
Improving health habits in forensic psychiatric patients
This trial tests a program to help people in a forensic psychiatric hospital improve their lifestyle habits, like diet and exercise, and metabolic health. It aims to support better health and well-being.
Vaxjo, Kronoberg CountyAges 18–64 - NCT06053567RecruitingPhase 3
Community smoking cessation for adults with high anxiety sensitivity
This study tests a smoking cessation program designed for adults who are very sensitive to anxiety (like feeling panicky about physical symptoms). It takes place at local YMCA centers and aims to help you quit smoking through a community-based approach.
Austin, TexasAges 18 years+ - NCT07075068Recruiting
How smoking affects leg movement and coordination
This study tests how cigarette addiction changes the speed and coordination of your legs. If you are a smoker or a non-smoker, researchers will compare your movement to see if smoking makes a difference.
Istanbul, ÜsküdarAges 18–25 - NCT07059377RecruitingPhase 3
Semaglutide to help smokers with diabetes quit
This study tests if the diabetes drug semaglutide can help people with type 2 diabetes stop smoking more easily. Participants will get either semaglutide or a placebo to see if it improves quit rates.
Ottawa, OntarioAges 18 years+ - NCT07024992RecruitingPhase 2
Smoking cessation app for African Americans with HIV
This study tests a mobile app and nicotine patches to help African American adults living with HIV quit smoking. It's designed for people who are ready to quit in two weeks and may experience anxiety or depression.
Oklahoma City, OklahomaAges 18 years+ - NCT07015151Recruiting
Mobile lung cancer screening for smokers and former smokers
This trial uses a mobile unit to screen people at high risk for lung cancer. It aims to catch the disease early, when it's easier to treat.
Pierre-BéniteAges 50–75 - NCT06988644Recruiting
Smoking cessation support for health workers
This study offers counseling at work to help health professionals quit smoking. It tests whether talking with a counselor at your workplace makes it easier to stop smoking for good.
Grenoble, isereAges 18 years+ - NCT06832085RecruitingPhase 4
Comparing stop-smoking medications for adult smokers in Ontario
This study compares three different stop-smoking treatments—nicotine patches, cytisine, or varenicline—to see which works best. If you want to quit or cut down in the next six months, this could help you find the right medication.
Ottawa, OntarioAges 18 years+ - NCT06617312RecruitingPhase 2
Cytisinicline and brain response to smoking cues
This study tests how a medicine called cytisinicline (similar to a plant-based stop-smoking aid) affects brain activity when you see or think about smoking. It may help researchers understand how the medicine works, even if you aren't ready to quit right now.
Los Angeles, CaliforniaAges 18–65 - NCT06595459RecruitingPhase 4
Options 2 study: testing nicotine replacement or medicines to help smokers switch
This study compares different nicotine replacement options to help people who smoke switch away from cigarettes. It may be a good fit if you smoke at least 5 cigarettes a day, aren't ready to quit in the next month, and are willing to stop using other stop-smoking aids.
Madison, WisconsinAges 21 years+ - NCT03199651Recruiting
Study for people with stage IV lung cancer
This study focuses on improving outcomes for people with stage IV non-small cell lung cancer by gathering health, treatment, and lifestyle information. It may help researchers understand what supports survival and care planning, especially for people who are current smokers or recent quitters.
Columbus, OhioAges 18 years+ - NCT06432985Recruiting
Smoking cessation coaching for veterans with cancer
This study tests a counseling program to help veterans who smoke quit smoking, especially those undergoing cancer treatment or lung cancer screening. It may improve health outcomes during cancer care.
San Francisco, CaliforniaAges 18 years+ - NCT06290869RecruitingPhase 3
Tobacco education and lung scan study
This study tests whether a special health education program, along with a free lung scan, can help long-term smokers quit. You may be able to join if you are a current smoker between 50 and 80 years old and have never had lung cancer.
Washington D.C., District of ColumbiaAges 50–80 - NCT05766553Recruiting
Virtual reality mindfulness to reduce cigarette cravings
This trial tests whether guided mindfulness meditation in virtual reality can lower cigarette cravings and help people quit smoking. It may help by reducing urges to smoke during stressful moments.
IteuilAges 18–75 - NCT05257629RecruitingPhase 3
Aggressive smoking quit program after heart problems
This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.
New Westminster, British ColumbiaAges 18 years+ - NCT04647097Recruiting
Quit smoking and alcohol to prevent pancreatitis coming back
This trial is studying whether stopping alcohol and quitting smoking can help keep acute pancreatitis from returning. It’s for people whose pancreatitis happened because of alcohol, and who smoke every day.
PécsAges 18–80 - NCT03912194RecruitingPhase 3
Training to help you quit smoking sooner and feel better
This Phase 3 study tests a quit-training program that teaches how to handle urges and negative feelings when you start cutting back or stopping smoking. You may benefit by improving your chances of quitting and reducing stress during withdrawal.
Birmingham, AlabamaAges 18 years+ - NCT07491627Enrolling by invitation
Nicotine's effect on gum disease treatment in smokers and non-smokers
This study looks at how smoking and nicotine affect the success of gum disease treatment. It compares results between smokers and non-smokers who have gum disease.
Liège, LiegeAges 18 years+ - NCT05445804RecruitingPhase 1
Oral cannabidiol (CBD) to help you quit tobacco
This Phase 1 study tests whether taking oral CBD can help people quit tobacco. It also checks safety and helps researchers learn how people respond to the treatment while they practice quitting.
Baltimore, MarylandAges 18–65 - NCT05863923Enrolling by invitation
Text message program to help people with HIV quit smoking
This study tests a texting program that sends messages to help people living with HIV who smoke quit smoking. It may help you reduce tobacco use using regular, motivational text messages.
Worcester, MassachusettsAges 18 years+ - NCT07425119Recruiting
Quit smoking trial for people who smoke a little each day
This study tests a text message program to help people who smoke 1-10 cigarettes most days but not daily quit. It uses cues and reminders sent to your phone to support your quit attempt.
Durham, North CarolinaAges 18 years+
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Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 148 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.