Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 159 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06583148Recruiting
Smoke-Free Home Program for Tribal Communities
This study aims to help make homes smoke-free in American Indian communities. It tests a program that supports people who smoke or live with a smoker to create a healthier home environment.
Atlanta, GeorgiaAges 18 years+ - NCT07390695Enrolling by invitation
Gamified exercise for hardcore smokers who are inactive
This trial tests if a fun, game-like exercise program can help heavy smokers who don't exercise much improve their heart and lung fitness and feel more ready to quit smoking.
Yogyakarta, Special Region of YogyakartaAges 17–45 - NCT03495024RecruitingPhase 4
Varenicline for quitting smoking in people with schizophrenia
This trial tests whether varenicline helps people with schizophrenia or schizoaffective disorder stop smoking. It also looks at related nervous-system side effects that can happen with some anti-psychotic medicines.
Philadelphia, PennsylvaniaAges 18–75 - NCT06626178Recruiting
AI for preventing smoking-related diseases
This study uses artificial intelligence to analyze CT scans and other health data to better identify people at risk for smoking-related diseases like lung cancer. Researchers hope to improve early detection and prevention.
MilanAges 18 years+ - NCT05188287Recruiting
Phone app support to help Black smokers quit
This study tests a culturally tailored smartphone app plus coaching to help African American adults quit smoking. You may qualify if you smoke daily, are ready to quit soon, and can use the quit supports they provide.
Oklahoma City, OklahomaAges 18 years+ - NCT07075068Recruiting
How smoking affects leg movement and coordination
This study tests how cigarette addiction changes the speed and coordination of your legs. If you are a smoker or a non-smoker, researchers will compare your movement to see if smoking makes a difference.
Istanbul, ÜsküdarAges 18–25 - NCT06595459RecruitingPhase 4
Options 2 study: testing nicotine replacement or medicines to help smokers switch
This study compares different nicotine replacement options to help people who smoke switch away from cigarettes. It may be a good fit if you smoke at least 5 cigarettes a day, aren't ready to quit in the next month, and are willing to stop using other stop-smoking aids.
Madison, WisconsinAges 21 years+ - NCT07585357Recruiting
Mobile app to help young smokers quit
This study tests a smartphone app that uses your location and daily habits to help you quit smoking. Researchers will send you personalized tips and support for 44 days to see if this approach helps you successfully stop smoking.
Baltimore, MarylandAges 18–40 - NCT06988644Recruiting
Smoking cessation support for health workers
This study offers counseling at work to help health professionals quit smoking. It tests whether talking with a counselor at your workplace makes it easier to stop smoking for good.
Grenoble, isereAges 18 years+ - NCT07420621Recruiting
Text messages and incentives to help pregnant smokers quit
This study tests whether adding extra text messages and small rewards can help pregnant women who smoke to quit. It is for those who already smoke daily and want help to stop.
Kansas City, KansasAges 18 years+ - NCT06290869RecruitingPhase 3
Tobacco education and lung scan study
This study tests whether a special health education program, along with a free lung scan, can help long-term smokers quit. You may be able to join if you are a current smoker between 50 and 80 years old and have never had lung cancer.
Washington D.C., District of ColumbiaAges 50–80 - NCT07419425RecruitingPhase 4
Help for Black adults to quit smoking
This study tests a program to help Black adults who smoke quit. It offers support and medication to help you stop smoking.
Phoenix, ArizonaAges 21 years+ - NCT07157813Enrolling by invitation
Improving health habits in forensic psychiatric patients
This trial tests a program to help people in a forensic psychiatric hospital improve their lifestyle habits, like diet and exercise, and metabolic health. It aims to support better health and well-being.
Vaxjo, Kronoberg CountyAges 18–64 - NCT03199651Recruiting
Study for people with stage IV lung cancer
This study focuses on improving outcomes for people with stage IV non-small cell lung cancer by gathering health, treatment, and lifestyle information. It may help researchers understand what supports survival and care planning, especially for people who are current smokers or recent quitters.
Columbus, OhioAges 18 years+ - NCT03912194RecruitingPhase 3
Training to help you quit smoking sooner and feel better
This Phase 3 study tests a quit-training program that teaches how to handle urges and negative feelings when you start cutting back or stopping smoking. You may benefit by improving your chances of quitting and reducing stress during withdrawal.
Birmingham, AlabamaAges 18 years+ - NCT03948893Recruiting
Behavior program to help you quit nicotine
This study tests a structured counseling/behavior treatment to help people who smoke become nicotine-free. If you’re interested in quitting, you may be asked to complete questionnaires and follow a quit plan as part of the research.
Columbia, MissouriAges 18 years+ - NCT04647097Recruiting
Quit smoking and alcohol to prevent pancreatitis coming back
This trial is studying whether stopping alcohol and quitting smoking can help keep acute pancreatitis from returning. It’s for people whose pancreatitis happened because of alcohol, and who smoke every day.
PécsAges 18–80 - NCT07024992RecruitingPhase 2
Smoking cessation app for African Americans with HIV
This study tests a mobile app and nicotine patches to help African American adults living with HIV quit smoking. It's designed for people who are ready to quit in two weeks and may experience anxiety or depression.
Oklahoma City, OklahomaAges 18 years+ - NCT05257629RecruitingPhase 3
Aggressive smoking quit program after heart problems
This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.
New Westminster, British ColumbiaAges 18 years+ - NCT05646485Recruiting
Bladder cancer screening for people at higher risk
This trial tests screening for bladder cancer in people who have higher risk due to age, smoking, and certain job exposures. It may help find bladder cancer earlier when treatment can be more effective.
Dallas, TexasAges 50 years+ - NCT05687604Recruiting
Telehealth program to reduce cancer risk behaviors
This trial offers a scalable telehealth (phone/video) program to help people improve cancer risk habits like low physical activity, higher body weight, and smoking. It may help by giving structured coaching and support in the privacy of your home.
Chicago, IllinoisAges 18 years+ - NCT05766553Recruiting
Virtual reality mindfulness to reduce cigarette cravings
This trial tests whether guided mindfulness meditation in virtual reality can lower cigarette cravings and help people quit smoking. It may help by reducing urges to smoke during stressful moments.
IteuilAges 18–75 - NCT06053567RecruitingPhase 3
Community smoking cessation for adults with high anxiety sensitivity
This study tests a smoking cessation program designed for adults who are very sensitive to anxiety (like feeling panicky about physical symptoms). It takes place at local YMCA centers and aims to help you quit smoking through a community-based approach.
Austin, TexasAges 18 years+ - NCT06432985Recruiting
Smoking Cessation Program for Veterans with Cancer
This study tests a video-based program to help Veterans who smoke and are being treated for cancer or lung cancer screening to quit. If you're a VA patient in San Francisco and currently smoke, you may be able to join.
San Francisco, CaliforniaAges 18 years+
Hear when a new Smoking Cessation trial opens
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Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 159 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.