Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 157 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06500117Recruiting
Mindfulness app for quitting smoking
This trial tests a digital mindfulness program on your smartphone to help you quit smoking and stay smoke-free. It's for adults who have a smoking-related health problem and are motivated to stop.
DijonAges 18 years+ - NCT06678243Recruiting
Smartphone app to help occasional smokers quit
This study tests a smartphone app (SiS4) designed to help people who smoke occasionally but not daily to quit. You will use the app to track your smoking and get support tailored to your schedule.
Boston, MassachusettsAges 18 years+ - NCT05672914Recruiting
Help quitting smoking after a psychiatric hospital stay
This study tests a program meant to help people stop smoking after they leave a psychiatric hospital. It may help you stay smoke-free longer by offering structured support during a high-risk time.
Austin, TexasAges 18 years+ - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT06678789Recruiting
Testing low vs high nicotine pouches for smokers
This study compares how low and high nicotine pouches affect adult smokers who want to try a tobacco-free option. You'll attend two visits in Charleston to check health markers.
Charleston, South CarolinaAges 21 years+ - NCT07501624Enrolling by invitation
Pharmacist-led tobacco treatment for HIV patients
This study works with pharmacists at six Ryan White HIV clinics to help people with HIV quit smoking or using tobacco. If you have HIV, are 21 or older, and have already met with a pharmacist about tobacco, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT05694637Enrolling by invitationPhase 4
Support to help daily smokers with HIV stay abstinent
This Phase 4 study tests a smoking-quit support approach (reinforcement and coaching) to help people with HIV stop smoking and stay smoke-free. It may help improve smoking abstinence while you continue HIV care.
Francistown, Central DistrictAges 18 years+ - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT07014124Recruiting
Helping smoking fathers quit for their sick child
This study tests whether helping smoking fathers quit can improve their child's health. You and your child will get support through a messaging app, and the child will provide saliva samples.
Hong Kong, PokfulamAges 18 years+ - NCT03514602Recruiting
Help quitting smoking to prevent childhood obesity
This study supports pregnant people who smoke to quit or cut down, using behavior-based coaching. It also measures how changes in smoking may help lower a child’s risk of developing obesity.
Buffalo, New YorkAges 18–39 - NCT06042361Enrolling by invitation
Making smoke-free housing fairer for residents
This study aims to make smoke-free policies more equitable in affordable housing communities. If you live in one of the six selected properties in Massachusetts, Maryland, or New York, you may be able to participate in a survey or a group discussion.
Boston, MassachusettsAges 18 years+ - NCT06575673Recruiting
Online skills training to help smokers quit and feel better
This trial tests an internet-based program that teaches skills to help you quit smoking and manage stress, anxiety, or low mood. You'll use your own device to get support and learn new ways to cope.
Tai Po, New TerritoriesAges 18–64 - NCT05897346Recruiting
Train secondary students to be anti-smoke ambassadors
This trial teaches secondary school students how to promote not smoking and act as “anti-smoke ambassadors.” It’s testing whether a structured school training approach can improve students’ readiness to help prevent smoking among peers.
Hong Kong, Hong Kong,ChinaAges Any age - NCT06451029Recruiting
Preventing diseases caused by smoking
This study is looking at ways to prevent smoking-related diseases. It enrolls long-term smokers who are age 50 or older and who are not planning to quit.
Milan, Italy, MilanAges 50 years+ - NCT07061522Recruiting
Smoking effects on leg speed and coordination
This study looks at how smoking affects how fast and smoothly you can move your legs. If you are a young adult smoker, your participation helps researchers understand how smoking might slow down your reflexes and coordination.
Istanbul, ÜsküdarAges 18–25 - NCT07198971Recruiting
Music therapy to help cancer patients quit smoking
This study tests whether adding music therapy sessions can help people with cancer quit smoking more easily. You'll work with a tobacco addiction nurse and a music therapist to see if the music part makes it easier to stick with quitting.
Montpellier, HeraultAges 18 years+ - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT05415761Recruiting
Mobile phone support to help you quit smoking in clinic
This study tests different texting/app-based ways to help people quit smoking, especially those who may have less access to care. You may be assigned to one approach and get support through your phone.
Gainesville, FloridaAges 21 years+ - NCT06876831Recruiting
Lung cancer screening for current and recent smokers
This study aims to create a program to help people get screened for lung cancer while they are in the hospital. It is for people who are at higher risk due to their age and smoking history.
New York, New YorkAges 50–80 - NCT07322796Recruiting
Quit smoking before lung biopsy
This trial tests whether helping people quit smoking before a lung biopsy (bronchoscopy or CT-guided needle) improves the procedure or reduces complications. If you smoke and have a suspicious lung nodule, this study may help you quit while getting the care you need.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT07455513Recruiting
Smoking cessation help for people with lung cancer
This study tests a new resource to help smokers who have or may have lung cancer quit smoking. The goal is to see if this resource makes it easier to stop smoking.
Columbus, OhioAges 21 years+ - NCT05732272RecruitingPhase 3
Extended quitting treatment for African American adults who smoke
This study tests a longer smoking-cessation treatment to help people quit and stay smoke-free. It specifically targets African American adults who are ready to quit and can take study medication for about 6 months.
Kansas City, MissouriAges 18 years+ - NCT06583148Recruiting
Smoke-Free Home Program for Tribal Communities
This study aims to help make homes smoke-free in American Indian communities. It tests a program that supports people who smoke or live with a smoker to create a healthier home environment.
Atlanta, GeorgiaAges 18 years+ - NCT07390695Enrolling by invitation
Gamified exercise for hardcore smokers who are inactive
This trial tests if a fun, game-like exercise program can help heavy smokers who don't exercise much improve their heart and lung fitness and feel more ready to quit smoking.
Yogyakarta, Special Region of YogyakartaAges 17–45
Hear when a new Smoking Cessation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 157 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.