Clinical trials
Spasticity clinical trials
Below are recruiting spasticity clinical trials, each written for real people, not researchers. We’re tracking 154 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07747961Recruiting
Virtual reality games for children with cerebral palsy
This trial tests whether playing virtual reality games, designed as part of a rehab program, can help improve movement and daily skills in children with a specific type of cerebral palsy (spastic diplegia). It may be a fun and engaging way to support physical therapy.
IslamabadAges 7–15 - NCT07704840RecruitingPhase 2
Testing a new pill for post-stroke arm stiffness
This study tests an experimental pill (BMS-986368) that targets two brain chemicals to reduce muscle stiffness after a stroke. It's for people who had a stroke in the last 4 to 18 months and have moderate tightness in their elbow and wrist.
Elkins Park, PennsylvaniaAges 18–80 - NCT07730086Recruiting
Using smartphones to study walking in children with cerebral palsy
This trial uses a smartphone app to measure how children with cerebral palsy walk. It aims to see if phone sensors can help doctors better understand gait problems.
Minya, Menia GovernorateAges 6–12 - NCT04752774RecruitingPhase 1/Phase 2
Botox-like injection study for arm spasticity after stroke
This trial tests whether IPN10200, a Botox-like treatment, is safe and helps reduce stiff, tight upper-arm muscles caused by spasticity after stroke or brain injury. You may be able to join if you meet specific timing, prior-treatment, and muscle-stiffness measurements.
Downey, CaliforniaAges 18–70 - NCT07715006Recruiting
Spinal nerve stimulation for children with cerebral palsy
This study adds a mild electrical stimulation to the spinal nerves during a planned SDR surgery for children with cerebral palsy, to see if it helps improve movement more than the surgery alone.
Pittsburgh, PennsylvaniaAges 3–14 - NCT03206190Recruiting
Study for early SPG4 symptoms in family members
This study looks at people in families with a known SPG4 gene change (a SPAST mutation) to understand early, subtle signs and the beginning of symptoms. It may help researchers find better ways to detect SPG4 earlier, before full walking problems start.
TübingenAges 18–70 - NCT03981276Recruiting
Study aims to understand inherited walking stiffness disorders
This study looks at the causes and biology (“biomarkers”) of hereditary spastic paraplegias and related conditions. You may join as someone with the condition, a family member without symptoms, or a healthy person, to help researchers understand what’s happening in the nervous system.
InnsbruckAges Any age - NCT04006418Recruiting
Study of spastic paraplegia in patients and healthy controls
This study enrolls people diagnosed with spastic paraplegia and also compares them with healthy people. It helps researchers learn more about the condition and may guide future care or treatments.
FuzhouAges Any age - NCT07694804Recruiting
Physical therapy for arm and hand function in children with cerebral palsy
This study tests two types of physical therapy to help children with spastic diplegic cerebral palsy improve the use of their arms and hands. The treatments focus on stretching and coordination exercises, and they may help your child with daily activities.
Mansehra, KPKAges 6–12 - NCT05147441Recruiting
Freezing the obturator nerve for tight hip muscles
This trial looks at cryoneurotomy, a procedure that “freezes” a nerve, to reduce spasticity (tight, stiff muscles) in the hip adductors. It may help some people with spasticity who are already receiving this standard nerve-freezing treatment as part of their care.
Victoria, British ColumbiaAges 12 years+ - NCT05179473Recruiting
Predict and diagnose stiffness after a recent stroke
This study looks at how to predict and measure spasticity (muscle stiffness and tightness) in people after a recent stroke. It may help clinicians better diagnose and understand what to expect as you recover.
Montreal, QuebecAges 18–85 - NCT05197764Recruiting
Track muscle growth in young children with spastic cerebral palsy
This study looks at how the muscles in the body grow in infants and young children with spastic cerebral palsy (a type of movement difference). It may help doctors better understand normal growth patterns and how care choices affect muscle development.
Leuven, Vlaams-BrabantAges 6 months–9 years - NCT05226637Recruiting
Shockwave plus botox-like treatment versus standard care for arm spasticity
This study tests whether adding shockwave treatment to botulinum toxin type A (a botox-like injection) improves outcomes for people with stiff, tight upper-arm muscles after brain injury, stroke, or cerebral palsy. It also compares this to standard botulinum toxin care alone.
Edmonton, AlbertaAges 18–99 - NCT05649930Recruiting
Power training for tight calf muscles in children with spastic paresis
This trial tests whether a specific exercise program that strengthens leg muscle power can improve calf muscle length and strength in children with spastic paresis (stiffness from the brain or nerves). If it works, it may help children move more easily and build stronger calves.
AmsterdamAges 4–18 - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT05926596Recruiting
Leg stretching with an on-demand exoskeleton for spasticity
This trial studies whether a wearable exoskeleton that helps with leg stretching can reduce stiffness and improve movement in people with spasticity after a spinal cord injury. It may help you stretch more safely and comfortably, but you must meet specific health and device-wear requirements.
Syracuse, New YorkAges 18 years+ - NCT06001736Recruiting
Nerve transfer surgery for arm weakness after stroke
This study tests a surgery called CC7 transfer, where a nerve from your healthy side is moved to help your weaker arm. It is for people whose arm has stopped getting better after a stroke and still has significant weakness.
Lebanon, New HampshireAges 18–65 - NCT06017960Recruiting
Dry needling for leg stiffness after stroke
This study checks if a treatment called dry needling (putting thin needles into tight muscles) can help reduce leg stiffness after a stroke. It uses ultrasound and muscle activity readings to see how well it works.
Madrid, MadridAges 18 years+ - NCT06229626Recruiting
Intensive home training for hereditary spastic paraparesis SPG4
This trial tests an intensive, video-based exercise program for people with a specific type of hereditary spastic paraparesis (SPG4). It aims to see if adding extra training at home can improve walking and strength.
ParisAges 18 years+ - NCT06270550Recruiting
Movement therapy for children with spastic diplegia
This study tests a movement therapy called Dynamic Movement Intervention to help children with spastic diplegia (a type of cerebral palsy) improve their walking and balance. It may be a good fit if your child is between 4 and 7, can walk short distances, and has mild muscle tightness.
CairoAges 4–7 - NCT06281223Recruiting
Brain and spinal cord connection study in spasticity
This study looks at how the brain and spinal cord connect in children with spasticity (muscle stiffness). It will help doctors understand more about this condition by studying patients who are already scheduled for surgery to reduce stiffness.
NiceAges 3–17 - NCT06365476Recruiting
Shockwave therapy for arm stiffness after stroke
This trial tests whether shockwave therapy (gentle sound waves) can help relax stiff wrist and finger muscles after a stroke. It is for adults who have had one stroke and have noticeable muscle tightness in their arm.
Taipei, TaipeiAges 18 years+ - NCT06478238RecruitingEarly Phase 1
Calcium folinate for hereditary spastic paraplegia type 56
This trial tests a drug called calcium folinate (a form of vitamin B9) to see if it can help people with a rare genetic type of spastic paraplegia (SPG56). It aims to improve leg stiffness and weakness caused by a specific gene change.
Shanghai, Shanghai MunicipalityAges Any age - NCT06494618Recruiting
Botulinum toxin plus shockwave for leg spasticity in cerebral palsy
This study tests if combining botulinum toxin injections with radial extracorporeal shockwave therapy (RESWT) works better than injection alone for reducing leg spasticity in children with cerebral palsy. If your child has spasticity in leg muscles and is already receiving botulinum toxin, they may benefit from this additional therapy.
Istanbul, KadikoyAges 2–18
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Common questions
- Are there clinical trials for spasticity?
- Yes. Clin2 currently lists 154 recruiting spasticity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spasticity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spasticity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.