Clinical trials
Sputum clinical trials
Below are recruiting sputum clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06508008Recruiting
Safe sputum suction for stroke coma patients
This study tests a safer way to remove mucus from the airway in people who are in a coma after a stroke.
Nantong, JiangsuAges 20–90 - NCT07751705Recruiting
Sputum collection with a chest vibration device for COPD
This study tests whether a chest vibration device helps people with COPD produce sputum (phlegm) more easily during a breathing test. It may help researchers collect better samples to understand and treat COPD.
Hanover, Lower SaxonyAges 40–70 - NCT04890938Recruiting
Sputum-guided care to help manage COPD flare-ups
This trial tests a COPD care plan guided by what’s found in your mucus (sputum), along with comprehensive case management. It aims to reduce COPD flare-ups and improve day-to-day health for people with a history of frequent exacerbations.
Hamilton, OntarioAges 40 years+ - NCT04923958Recruiting
Testing new TB screening and diagnostic tests
This study tests rapid TB screening and lab-style diagnostic methods to see how well they find TB disease and TB that is resistant to rifampin (a key TB drug). It may help doctors diagnose TB faster and more accurately, especially in people at higher risk.
TbilisiAges 12 years+ - NCT05086432Recruiting
Test sputum-guided care to reduce cough in lung scarring
This study uses analysis of mucus (sputum) to guide treatment with the goal of reducing long-lasting cough in adults with interstitial lung disease (ILD). You may be asked to provide sputum samples and may receive treatment decisions based on those results.
Hamilton, OntarioAges 18 years+ - NCT06950892Recruiting
Remote sputum collection study for cystic fibrosis
This study tests if people with cystic fibrosis can collect sputum samples at home and mail them in, instead of coming to the clinic. It aims to make participation easier for patients.
Denver, ColoradoAges 18 years+ - NCT07759583Recruiting
Breathing exercises for smog-related pneumonia
This study tests two breathing techniques—Buteyko breathing and incentive spirometry—to see which better improves oxygen levels, breathing difficulty, exercise tolerance, and mucus clearance in people with pneumonia caused by air pollution.
Lahore, Punjab ProvinceAges 25–40 - NCT03909477Recruiting
Study of MRI brain scans in cannabis smokers over time
This study follows people who currently or used to smoke cannabis to see how cannabis use may change certain MRI scan signals in the brain over time. You may help researchers understand the effects of cannabis smoking and how brain imaging changes can be measured safely.
London, OntarioAges 18–85 - NCT05280132Recruiting
Testing quick tests to shorten antibiotics in severe COPD flare
This trial checks whether using fast test results (PCR from samples, a blood marker called procalcitonin, and sputum appearance) can safely reduce how long you need antibiotics during a severe COPD flare. It may help you receive fewer days of antibiotics while still controlling the infection risk.
ParisAges 18 years+ - NCT04761393Recruiting
Testing a lung protein in COPD sputum samples
This study looks at a lung protein called MMP12 in sputum (mucus) to better understand COPD. It may help researchers learn which COPD changes are linked to disease severity and lung damage.
Hamilton, OntarioAges 40–85 - NCT07347366Recruiting
Chest vibration device for mucus clearance in pneumonia
This study tests a device that uses gentle vibrations on your chest to help move mucus out of your lungs. It is for hospitalized adults who have trouble coughing up phlegm due to pneumonia or similar infections.
Yangsan, Gyeongsangnam-doAges 18 years+ - NCT04616313Recruiting
MRI and breathing tests in people who vape
This study uses a special lung scan (MRI) and breathing tests to understand how vaping affects lung structure and function. It may help researchers learn what early lung changes happen after starting vaping, even if you don’t feel sick.
London, OntarioAges 16 years+ - NCT07232550Recruiting
Breathing study for children needing bronchoscopy
This study collects samples (like fluid from the lungs) during a planned bronchoscopy to look for new ways to understand and predict children's breathing problems. It might help if your child already needs this procedure for a medical reason.
WarsawAges Up to 17 years - NCT07168993Recruiting
Testing a new sputum test for lung cancer in high-risk adults
This study tests a new, non-invasive sputum test (FlowPath Lung) to see if it can accurately detect lung cancer in people at high risk who have a lung nodule. If you are between 50 and 80, have a smoking history, and have a lung nodule, this test may help decide if further steps are needed.
Palo Alto, CaliforniaAges 50–80 - NCT03457415Recruiting
Provide sputum sample for lung cancer testing
This study collects sputum (mucus from deep in the lungs) to help test or label lung cancer-related results. You may be placed in a healthy, high-risk, or cancer group depending on your smoking history and whether you already have a lung cancer diagnosis.
Summit, New JerseyAges 21 years+ - NCT04436991Recruiting
Testing antibiotic doses in older adults in the emergency room
This study looks at how best to dose certain antibiotics in people age 75 and older who are admitted to a geriatric (older-adult) hospital unit. It aims to measure antibiotic levels in the body to see whether dosing can be improved for older patients.
GhentAges 75 years+ - NCT05192499Recruiting
Study gut-and-lung bacteria in very young children with asthma
This study looks at whether differences in the body’s bacteria (in the gut and/or airways) can help predict which toddlers with asthma may develop a more severe form. It may help doctors identify children at higher risk earlier so they can be monitored more closely.
Brest, FinistèreAges 1–3 - NCT05270525RecruitingPhase 2
Ensifentrine nebulizer trial to reduce COPD airway inflammation markers
This trial tests ensifentrine, given through a nebulizer, to see if it changes inflammation-related substances found in mucus/phlegm in people with COPD. It may help doctors understand whether this treatment improves COPD biology and could lead to better symptom control.
Birmingham, AlabamaAges 40–80 - NCT05937334Recruiting
Long-term study of asthma in adults in China
This study follows adults with asthma over about 2 years to learn more about asthma and how people do over time. If you qualify, you’ll be asked to join regular visits and follow the study plan.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06113861Recruiting
Better TB testing for kids in Bolivia
This trial tests new ways to diagnose tuberculosis (TB) in children with breathing problems. It aims to make TB detection faster and more accurate for kids who might have the infection.
Santa CruzAges 2 months–14 years - NCT06237660Recruiting
Wheeze study for young children
This study looks at young children (ages 1-5) who have had severe wheezing episodes that needed hospital care. It aims to find biomarkers (clues in the body) that could help predict which children might develop asthma later.
LondonAges 1–5 - NCT06506617Recruiting
Testing pneumonia patients in the emergency room
This trial studies a new testing method (HCAP-Pcr) for people with pneumonia caught in the hospital or other healthcare settings. Doctors will use a special lung washing procedure called bronchoalveolar lavage to quickly identify the cause of the infection, which could help guide treatment faster.
Florence, Tuscany/ItalyAges 18 years+ - NCT07125274Recruiting
New Sputum-Free Test for TB Diagnosis
This study is testing a new way to diagnose tuberculosis (TB) without needing sputum (phlegm) samples. It aims to find a simpler, faster method for people with possible TB or other lung infections.
HamburgAges 18 years+ - NCT07375667Recruiting
Airway suction guidance in ventilated patients
This trial uses dynamic airway resistance and machine learning to guide when sputum suction is needed in ventilated patients with ARDS, AECOPD, or severe pneumonia.
Bengbu, AnhuiAges 18–90
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Common questions
- Are there clinical trials for sputum?
- Yes. Clin2 currently lists 29 recruiting sputum studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sputum trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sputum trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.