Clinical trials
Sputum clinical trials
Below are recruiting sputum clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06508008Recruiting
Safe sputum suction for stroke coma patients
This study tests a safer way to remove mucus from the airway in people who are in a coma after a stroke.
Nantong, JiangsuAges 20–90 - NCT07751705Recruiting
Using sound waves to collect lung mucus samples in COPD patients
This trial is testing whether a device that uses sound waves can help collect lung mucus samples more easily in people with COPD. It compares two groups: current smokers and ex-smokers, to see if the device works differently for them.
Hanover, Lower SaxonyAges 40 years+ - NCT04890938Recruiting
Sputum-guided care to help manage COPD flare-ups
This trial tests a COPD care plan guided by what’s found in your mucus (sputum), along with comprehensive case management. It aims to reduce COPD flare-ups and improve day-to-day health for people with a history of frequent exacerbations.
Hamilton, OntarioAges 40 years+ - NCT05086432Recruiting
Test sputum-guided care to reduce cough in lung scarring
This study uses analysis of mucus (sputum) to guide treatment with the goal of reducing long-lasting cough in adults with interstitial lung disease (ILD). You may be asked to provide sputum samples and may receive treatment decisions based on those results.
Hamilton, OntarioAges 18 years+ - NCT04923958Recruiting
Testing new TB screening and diagnostic tests
This study tests rapid TB screening and lab-style diagnostic methods to see how well they find TB disease and TB that is resistant to rifampin (a key TB drug). It may help doctors diagnose TB faster and more accurately, especially in people at higher risk.
TbilisiAges 12 years+ - NCT07168993Recruiting
Sputum test for lung cancer in high-risk people with lung nodules
This study tests a new, non-invasive test that looks at a sputum (phlegm) sample to see if it can detect lung cancer in people who have a lung nodule. The test might help avoid more invasive procedures and help doctors decide next steps.
Palo Alto, CaliforniaAges 50–80 - NCT06113861Recruiting
Better TB testing for kids in Bolivia
This trial tests new ways to diagnose tuberculosis (TB) in children with breathing problems. It aims to make TB detection faster and more accurate for kids who might have the infection.
Santa CruzAges 2 months–14 years - NCT01789229Recruiting
Tumor and inflammation sample bank for one specific condition
This study builds a secure “tumor sample bank” using tissue collected from people who currently have one diagnosed condition, either cancer (malignant disease) or an ongoing inflammatory condition. Your samples could help researchers study your disease and develop better treatments in the future.
ViennaAges 18 years+ - NCT05937334Recruiting
Long-term study of asthma in adults in China
This study follows adults with asthma over about 2 years to learn more about asthma and how people do over time. If you qualify, you’ll be asked to join regular visits and follow the study plan.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07759583Recruiting
Breathing exercises for smog-related pneumonia
This study tests two breathing techniques—Buteyko breathing and incentive spirometry—to see which better improves oxygen levels, breathing difficulty, exercise tolerance, and mucus clearance in people with pneumonia caused by air pollution.
Lahore, Punjab ProvinceAges 25–40 - NCT05192499Recruiting
Study gut-and-lung bacteria in very young children with asthma
This study looks at whether differences in the body’s bacteria (in the gut and/or airways) can help predict which toddlers with asthma may develop a more severe form. It may help doctors identify children at higher risk earlier so they can be monitored more closely.
Brest, FinistèreAges 1–3 - NCT04761393Recruiting
Testing a lung protein in COPD sputum samples
This study looks at a lung protein called MMP12 in sputum (mucus) to better understand COPD. It may help researchers learn which COPD changes are linked to disease severity and lung damage.
Hamilton, OntarioAges 40–85 - NCT07460154Recruiting
Structured review to improve COPD management
This trial tests a structured review process to help people with COPD who have needed multiple steroid pills in the past year. It aims to improve care and prevent future harm from the condition.
North ShieldsAges 35 years+ - NCT07375667Recruiting
Airway suction guidance in ventilated patients
This trial uses dynamic airway resistance and machine learning to guide when sputum suction is needed in ventilated patients with ARDS, AECOPD, or severe pneumonia.
Bengbu, AnhuiAges 18–90 - NCT07347366Recruiting
Chest vibration device for mucus clearance in pneumonia
This study tests a device that uses gentle vibrations on your chest to help move mucus out of your lungs. It is for hospitalized adults who have trouble coughing up phlegm due to pneumonia or similar infections.
Yangsan, Gyeongsangnam-doAges 18 years+ - NCT03457415Recruiting
Provide sputum sample for lung cancer testing
This study collects sputum (mucus from deep in the lungs) to help test or label lung cancer-related results. You may be placed in a healthy, high-risk, or cancer group depending on your smoking history and whether you already have a lung cancer diagnosis.
Summit, New JerseyAges 21 years+ - NCT07232550Recruiting
Breathing study for children needing bronchoscopy
This study collects samples (like fluid from the lungs) during a planned bronchoscopy to look for new ways to understand and predict children's breathing problems. It might help if your child already needs this procedure for a medical reason.
WarsawAges Up to 17 years - NCT07125274Recruiting
New Sputum-Free Test for TB Diagnosis
This study is testing a new way to diagnose tuberculosis (TB) without needing sputum (phlegm) samples. It aims to find a simpler, faster method for people with possible TB or other lung infections.
HamburgAges 18 years+ - NCT06950892Recruiting
Remote sputum collection study for cystic fibrosis
This study tests if people with cystic fibrosis can collect sputum samples at home and mail them in, instead of coming to the clinic. It aims to make participation easier for patients.
Denver, ColoradoAges 18 years+ - NCT05280132Recruiting
Testing quick tests to shorten antibiotics in severe COPD flare
This trial checks whether using fast test results (PCR from samples, a blood marker called procalcitonin, and sputum appearance) can safely reduce how long you need antibiotics during a severe COPD flare. It may help you receive fewer days of antibiotics while still controlling the infection risk.
ParisAges 18 years+ - NCT04616313Recruiting
MRI and breathing tests in people who vape
This study uses a special lung scan (MRI) and breathing tests to understand how vaping affects lung structure and function. It may help researchers learn what early lung changes happen after starting vaping, even if you don’t feel sick.
London, OntarioAges 16 years+ - NCT03909477Recruiting
Study of MRI brain scans in cannabis smokers over time
This study follows people who currently or used to smoke cannabis to see how cannabis use may change certain MRI scan signals in the brain over time. You may help researchers understand the effects of cannabis smoking and how brain imaging changes can be measured safely.
London, OntarioAges 18–85 - NCT00900419Recruiting
Check biomarkers during bronchoscopy in breathing and throat pre-cancer
This study looks at “biomarkers” (measurable signals in samples) taken during bronchoscopy or related procedures in people with severe airway pre-cancer or certain lung/throat cancers, and in healthy volunteers. The goal is to better understand what these biomarkers mean and how they might help with diagnosis, staging, or monitoring.
Aurora, ColoradoAges 21–90 - NCT04579211Enrolling by invitation
Urine testing to skip repeated NTM sputum checks in cystic fibrosis
This study looks at whether a urine test (instead of repeated sputum—mucus—from the lungs testing) can help determine who with cystic fibrosis does not have certain lung germs called NTM. If the urine test works, it could reduce the need for lung sample testing while still keeping people safe.
Denver, ColoradoAges 18 years+
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Common questions
- Are there clinical trials for sputum?
- Yes. Clin2 currently lists 25 recruiting sputum studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sputum trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sputum trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.