Stroke, Cerebrovascular clinical trials

Breathing nitric oxide during clot-removal for stroke

This Phase 1 study tests whether inhaled nitric oxide (a gas breathed through a ventilator) can improve outcomes in people having a specific kind of emergency stroke procedure to remove a clot from the brain. It focuses on patients who need general anesthesia for the clot-removal procedure and have imaging results that suggest salvageable brain tissue.

Ultrasound to study neck artery plaques and predict risk

This study uses different ultrasound techniques to look at plaques in the neck artery and predict future heart or stroke events. It may help doctors understand which plaques are more dangerous.

Emergency stroke unit for ischemic stroke within 6 hours

This trial tests a dedicated emergency stroke unit for people with ischemic stroke who can get treatment within 6 hours of symptoms starting. It aims to see if this special care area improves outcomes.

High-intensity swallow therapy after ischemic stroke

This trial tests a more intensive swallow-therapy program for people with difficulty swallowing soon after an ischemic stroke. It may help improve safety and function when eating and drinking.

Calculus Bovis Sativus for Stroke Recovery

This study tests an investigational traditional Chinese medicine called Calculus Bovis Sativus (CBS) for people who have had an ischemic stroke or have small vessel disease in the brain. It aims to see if CBS can help recovery and is safe to use.

Tiprogrel for recent minor stroke or high-risk TIA

This trial tests a new anti-platelet drug called Tiprogrel to prevent another stroke in people who recently had a minor stroke or a transient ischemic attack (TIA) with certain artery narrowing or plaques. It aims to see if this medicine is safe and works better than current treatments.

Study on blood thinners and artery health for small vessel stroke

This study tests whether a combination of antiplatelet drugs and artery-stabilizing medication can improve recovery after a small stroke caused by damage to tiny blood vessels in the brain. It may help prevent further strokes and support healing.

Brain cooling plus clot removal for large artery stroke

This trial tests a new treatment that combines cooling the brain with a catheter and removing the clot to restore blood flow — for people who have had a major stroke in the front part of the brain within the last 24 hours.

Remote ischemic conditioning after aneurysm surgery

This trial tests a safe, non-invasive treatment called remote ischemic conditioning (using a blood pressure cuff on your leg) to see if it helps brain recovery after aneurysm surgery. It might reduce secondary damage and improve outcomes.

Vagus nerve stimulation for swallowing problems after stroke

This trial tests a non-invasive device that stimulates a nerve in the ear to help improve swallowing after a recent stroke. It may be an option if you have moderate swallowing difficulties diagnosed within the first week after your stroke.

Tenecteplase for stroke treatment 24-72 hours after symptoms start

This trial tests if the clot-busting drug tenecteplase can help people with a moderate to severe stroke when given 24 to 72 hours after symptoms began. It aims to see if this later treatment window can improve recovery and reduce disability.

Tegoprazan to prevent stomach problems after stroke

This study tests a stomach-protecting medicine called tegoprazan for people who have had a stroke and are starting antiplatelet therapy. It aims to prevent stomach complications like ulcers or bleeding.

Smartphone help to prevent another stroke after recent stroke or TIA

This trial tests a smartphone-based system that helps people who recently had a stroke or TIA manage their risk factors like high blood pressure or diabetes after leaving the hospital. It's designed to see if this tool can prevent another stroke.

Clot-busting therapy for stroke patients on blood thinners

This study tests whether giving a clot-busting medicine through an IV can help people who have had a stroke while taking a common blood thinner (apixaban, dabigatran, edoxaban, or rivaroxaban). It may be an option if your last dose of the blood thinner was 12 to 48 hours before the stroke and you arrive at the hospital within 4.5 hours of symptoms starting.

Tirofiban for recent mild stroke or TIA with narrowed brain artery

This trial tests the drug tirofiban (a blood thinner) to prevent another stroke in people who have had a mild stroke or high-risk TIA and have a narrowed artery in the brain. It must be started within 24 hours of symptoms.

Compare two aspirin doses after blunt vessel injury

This trial tests whether taking a lower-dose aspirin (81 mg) works as well as a higher-dose aspirin (325 mg) to prevent stroke after a blunt injury that affects blood vessels in the neck/head. It may help some patients lower their stroke risk with the simplest, safest dose.

Tenecteplase for mild stroke within 4.5 hours

This trial tests a clot-busting drug called tenecteplase for patients having a mild stroke (with weakness on one side or trouble speaking) who can get treatment within 4.5 hours. The goal is to see if this drug helps improve blood flow and reduces disability.

Study of treatment after a new brain artery dissection

This study looks at people who have had a fresh tear in a brain artery within the last month. The goal is to learn the best way to manage this condition and improve outcomes.

Understanding How Strokes Develop: A Research Study

This study follows people who have had or are at risk for stroke to understand what causes strokes and how they develop over time. By participating, you help researchers learn more about stroke prevention and treatment.

Brain Blood Flow Changes After Stroke Clot Removal

This study examines how blood flow in the brain changes after a minimally invasive procedure to remove a blood clot during an acute stroke. The research uses MRI imaging to understand brain recovery patterns and may help improve stroke treatment outcomes.

Stroke and quality of life study with caregivers

This study looks at quality of life for people who have had a recent stroke or mini-stroke, and their caregivers. You and a close relative or friend both take part in interviews and surveys over time.

Cognitive-motor training for stroke and Moyamoya disease

This trial tests a combined thinking and movement training program for people who have had a stroke or have Moyamoya disease and still have some thinking or movement problems. It may help improve both mental and physical abilities.

Testing a brain-wave device for stroke triage in ambulances

This trial is testing a portable EEG device (a non-invasive cap that measures brain activity) to help ambulance staff quickly determine if a patient is having a stroke. It aims to speed up diagnosis and care for people with suspected stroke symptoms.

Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography