Clinical trials · Connecticut
Substance Use Disorders clinical trials in Connecticut
We’re tracking 30 recruiting substance use disorders studies with a site in Connecticut — including Early Phase 1, Phase 1, Phase 1/Phase 2, Phase 2 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Connecticut
- NCT07800520RecruitingPhase 1
Brain imaging study for people with opioid use disorder
This study uses a special brain scan (PET) and MRI to look at how a protein in the brain, called CB1 (part of the body's natural pain and reward system), changes when people start treatment for opioid use disorder. It may help doctors understand how buprenorphine works and improve addiction treatments.
New Haven, ConnecticutAges 25–65 - NCT07221396Enrolling by invitation
A text-based program to help reduce stimulant use
This study tests a text-message program called LDART to help people who use cocaine or other stimulants cut down or quit. If you live in Connecticut, have a smartphone, and want to reduce your stimulant use, you may be able to join.
New Haven, ConnecticutAges 18 years+ - NCT06854757Recruiting
Support after losing a loved one to overdose
This study is for people who lost a loved one to an unintentional drug overdose in the past year. It looks at how families are doing after such a loss and what kind of support might help.
Farmington, ConnecticutAges 18 years+ - NCT06584448Recruiting
Drinking, acetate, and stress study
This study looks at how acetate (a substance produced when the body breaks down alcohol) affects stress and drinking. It tests if giving acetate can help people with alcohol use disorder (AUD) reduce their drinking.
New Haven, ConnecticutAges 18–60 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT06335407RecruitingPhase 1
Testing a new under-the-tongue med for alcohol use and trauma
This study tests a new sublingual (under-the-tongue) medication for people with alcohol use disorder who have also had a traumatic life event. It aims to see if the medication can help reduce drinking and related symptoms.
West Haven, ConnecticutAges 21–65 - NCT05547048RecruitingPhase 4
Phone-based support to help prevent HIV in justice-involved women
This study tests an integrated phone-based health program (e-health) designed for women involved with the justice system who have opioid use disorder. It aims to help people who qualify for HIV prevention (PrEP) stay protected, especially by using simple, ongoing support through phone access.
New Haven, ConnecticutAges 18 years+ - NCT05327504Recruiting
Writing therapy for PTSD and substance use in veterans
This study tests a structured “written exposure” therapy to help veterans with PTSD who also have a substance use disorder (SUD). It may help reduce PTSD symptoms while also supporting safer, more stable recovery.
West Haven, ConnecticutAges 18 years+ - NCT07520292RecruitingPhase 1
Testing NTX-2001 to reduce drinking in alcohol use disorder
This study tests whether a new medication called NTX-2001 can help people with alcohol use disorder drink less. Researchers will measure how the drug affects alcohol consumption and safety in adults aged 21–60.
New Haven, ConnecticutAges 21–60 - NCT07362082Recruiting
Telehealth treatment for opioid use disorder
This study tests whether treatment for opioid use disorder can be done effectively through telehealth (video calls and texts). It is designed for people who are not currently on medication for opioid addiction and want to start treatment from home.
New Haven, ConnecticutAges 18 years+ - NCT07029529RecruitingPhase 2
Apremilast for alcohol use disorder
This study tests whether a drug called apremilast can help people who drink heavily reduce their alcohol use. You will take the medication daily for several weeks and attend study visits to track your progress.
New Haven, ConnecticutAges 21–65 - NCT05957159RecruitingEarly Phase 1
Testing an alcohol brain imaging study based on opioid receptor balance
This early-phase study looks at how the brain’s opioid receptor balance may be different in people with alcohol use disorder (AUD), using brain scans and blood testing. It may help researchers understand why some people respond differently to alcohol and related treatments.
New Haven, ConnecticutAges 21–70 - NCT05781009RecruitingPhase 2
Pregnenolone treatment for alcohol use disorder
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
New Haven, ConnecticutAges 18–70 - NCT06371404Recruiting
Brain imaging study of stress and alcohol use disorders
This study uses a special brain scan to look at how stress and alcohol use affect the brain. It may help people with PTSD, alcohol use disorder, or healthy volunteers understand these conditions better.
New Haven, ConnecticutAges 18–70 - NCT06160284RecruitingPhase 1
Psilocybin for brain healing in opioid recovery
This study tests whether psilocybin, a psychedelic substance, can help change brain connections in people recovering from opioid use disorder. It involves brain scans and careful medical monitoring to explore new treatment options.
New Haven, ConnecticutAges 25–55 - NCT05042102RecruitingPhase 2
Donepezil plus brain training for alcohol use disorder
This Phase 2 study tests whether donepezil, along with structured cognitive (brain) training, can improve outcomes for people with alcohol use disorder. It will measure whether this combination helps after recent heavy drinking, while tracking safety over about 13 weeks.
West Haven, ConnecticutAges 18–80 - NCT05913752RecruitingPhase 1/Phase 2
Test drug CMND-100 in people with alcohol use disorder
This early study tests the safety and dosing of CMND-100 in first-time participants, including people with alcohol use disorder (AUD) and some healthy volunteers. It may help researchers understand whether the drug is safe, and how it might affect alcohol use in AUD.
New Haven, ConnecticutAges 18–60 - NCT07768007Recruiting
Methadone and memory study for opioid use disorder
This study tests whether a new approach can improve memory and mood in people taking methadone for opioid use disorder. It involves brain scans and may help with feelings of sadness or loss of interest.
New Haven, ConnecticutAges 18–50 - NCT07223398Recruiting
Making HIV care decisions with people who've been in the justice system
This trial helps people recently involved with the justice system and who use stimulants or opioids decide on HIV prevention or treatment. It tests a shared decision-making approach for taking HIV medication (ART) or PrEP.
New Haven, ConnecticutAges 18 years+ - NCT03764098RecruitingPhase 2
Guanfacine to reduce heavy drinking in adults with alcohol use disorder
This Phase 2 study tests whether guanfacine can reduce drinking in women and men who drink heavily and meet criteria for alcohol use disorder. It also looks at how the medicine affects drinking patterns in a controlled setting.
New Haven, ConnecticutAges 21–70 - NCT07488819Recruiting
Brain imaging study for people with PTSD or alcohol use disorder
This study uses a special brain scan (PET) to look at a protein called PDE4B in people with PTSD or alcohol use disorder. It may help researchers understand these conditions better.
New Haven, ConnecticutAges 18–70 - NCT06207162Recruiting
Brain scans and methadone treatment for opioid recovery
This study uses MRI scans over time to track brain changes in people with opioid use disorder who recently started methadone treatment. You can help researchers understand recovery patterns if you are early in your methadone journey and can commit to repeated visits.
New Haven, ConnecticutAges 18–50 - NCT05576350Recruiting
Coaching to reduce risky drinking and HIV risk
This study tests an intervention (coaching/skills training) to help reduce risky alcohol use and reduce behaviors that increase HIV risk. It may help you if you drink in an at-risk way and may benefit from HIV prevention like PrEP.
New Haven, ConnecticutAges 18–35 - NCT06214065Recruiting
Brain stimulation for social thinking in autism
This trial tests whether mild brain stimulation (TMS) over the temporoparietal junction can improve a social thinking skill called 'mentalizing' in adults with autism. You would have MRI scans, cognitive tasks, and several TMS sessions.
Hartford, ConnecticutAges 18–35
Substance Use Disorders trials by city in Connecticut
Where these studies are running in Connecticut
Institutions with a site for the recruiting substance use disorders studies listed above.
- Yale University · 12 studies
- Connecticut Mental Health Center · 2 studies
- VA Connecticut Healthcare System · 2 studies
- APT Foundation
- Connecticut Mental Health Center - Yale School of Medicine
- Connecticut Office of the Chief Medical Examiner
- MRRC at The Anlyan Center
- Olin Neuropsychiatry Research Center (ONRC)
What taking part in a substance use disorders study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Substance Use Disorders trials in other states
Common questions
- Are there substance use disorders clinical trials in Connecticut?
- Yes. We're currently tracking 30 recruiting substance use disorders studies with a site in Connecticut, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a substance use disorders study in Connecticut?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Connecticut to take part?
- Not necessarily. These studies have a site in Connecticut, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New substance use disorders studies open in Connecticut regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.