Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03506867Enrolling by invitation
Test program to help recent smokers in Ottawa or Toronto
This trial offers a health program for people age 16+ who smoked recently and live in Ottawa or Toronto. It aims to help with quitting and follow-up over one year, especially for people facing financial hardship or housing instability.
Ottawa, OntarioAges 16 years+ - NCT07227545Recruiting
Brain stimulation study for alcohol use disorder
This study tests a non-invasive brain stimulation treatment (using a mild electrical current) to see if it can help people reduce their alcohol use. It aims to improve symptoms of alcohol use disorder, which may help with recovery.
ShanghaiAges 18–60 - NCT07638553RecruitingPhase 3
Psilocybin to prevent alcohol relapse with depression
This study tests whether psilocybin (a psychedelic compound) can help people with severe alcohol use disorder stay sober longer, especially if they also have depression. Participants receive guided psilocybin sessions alongside counseling to reduce the risk of returning to heavy drinking.
BayonneAges 18 years+ - NCT07184983Recruiting
Brain stimulation for cannabis use disorder
This study tests whether a gentle brain stimulation technique (called tDCS) can help people who want to cut down or stop using cannabis. You'll wear a headband-like device during sessions at NYU, and the study team will check in with you over time.
New York, New YorkAges 22–65 - NCT06675539Recruiting
Testing a tool to predict alcohol withdrawal severity in French speakers
This study tests a French version of a questionnaire (PAWSS) that helps doctors predict how severe alcohol withdrawal might be. It is for people aged 18 to 60 who are dependent on alcohol and planning a supervised detox or being hospitalized for another reason.
ÉtampesAges 18–60 - NCT07365293Recruiting
Support for Families Affected by Opioid or Meth Use
This study tests a program that helps parents who are using opioids or methamphetamines get support for themselves and their families. It may be a good fit if you have Medicaid, live in certain counties, and are open to working with a coach.
Eugene, OregonAges Any age - NCT06405607RecruitingPhase 2
Psilocybin vs Ketamine for Alcohol Use Disorder Trial
This trial tests two psychedelic-assisted therapies, psilocybin and ketamine, to see which works better for reducing heavy drinking in people with alcohol use disorder (AUD). You'll receive either drug along with counseling, and the study monitors safety closely.
Iowa City, IowaAges 21–65 - NCT07330349Recruiting
Trauma and substance use in penetrating abdominal injury
This study looks at alcohol, drug use, and painkiller use in people with a penetrating abdominal injury (like a stab or gunshot wound to the belly). It aims to understand how these substances affect patient outcomes.
Cali, Valle del Cauca DepartmentAges 15 years+ - NCT06837662Recruiting
Counseling and peer support for opioid use disorder in primary care
This study tests whether adding counseling and peer support helps people with opioid use disorder and other medical problems stay in treatment. It is for patients seen at Central City Concern in Portland who are starting or restarting medication for opioid use disorder, or who are not yet on medication but want help.
Portland, OregonAges 18 years+ - NCT06484075RecruitingPhase 1/Phase 2
Sleep medication for alcohol use disorder
This study tests whether suvorexant, a sleep aid, can help people with alcohol use disorder by looking at brain changes. It may improve sleep and reduce drinking.
Bethesda, MarylandAges 18–75 - NCT06835907Recruiting
Baclofen for anxiety and alcohol use disorder
This trial tests if baclofen can help people with both anxiety and alcohol use disorder. It is an open-label study, meaning everyone knows they are taking the medication. Researchers want to see if it supports people in staying alcohol-free.
Jette, Brussels CapitalAges 18–65 - NCT07214207RecruitingPhase 2
Testing a sleep medicine for alcohol use disorder and stress-related drinking
This trial tests whether a medicine called suvorexant, which is used for sleep, can help people with alcohol use disorder drink less, especially when stressed. You would receive the medicine or a placebo, and researchers will track your drinking and stress levels over several weeks.
Columbus, OhioAges 18–65 - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT06852170Recruiting
Data-driven decisions for substance use services
This trial helps decision-makers use data to improve substance use services and prevent overdoses. It is for professionals who shape policy or run programs in behavioral health, public health, law enforcement, or advocacy.
Eugene, OregonAges 18 years+ - NCT06639373Recruiting
Road to Recovery Initiative
This study looks at how people recover when they use Road to Recovery services in British Columbia. If you have used these services before, you may be able to share your experiences to help improve recovery support for others.
Vancouver, British ColumbiaAges 18 years+ - NCT06405074Recruiting
Ultrasound for Smoking Cessation in Veterans
This study tests if a gentle ultrasound aimed at a specific part of the brain (the insula) can help veterans who smoke tobacco reduce or quit smoking. The research is for veterans who smoke heavily and are motivated to think about quitting but are not currently in treatment.
Washington D.C., District of ColumbiaAges 18–75 - NCT05445804RecruitingPhase 1
Oral cannabidiol (CBD) to help you quit tobacco
This Phase 1 study tests whether taking oral CBD can help people quit tobacco. It also checks safety and helps researchers learn how people respond to the treatment while they practice quitting.
Baltimore, MarylandAges 18–65 - NCT07773649RecruitingEarly Phase 1
PET scan to study energy use in brain of people with cocaine use disorder
This study uses a special PET scan to look at how brain cells make energy, which may be changed by cocaine. It might help researchers find better ways to treat cocaine use disorder.
Pittsburgh, PennsylvaniaAges 18–45 - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT05674409Recruiting
Telehealth family program for moderate to severe alcohol use
This study tests a brief treatment delivered by video that involves a Veteran and a concerned family member or friend. It’s meant for Veterans with ongoing alcohol problems, to see if family involvement helps them change drinking and stay safe during treatment.
Charleston, South CarolinaAges 21 years+ - NCT07273955Recruiting
Alcohol use and weight-loss surgery: a study of addiction follow-up
This study looks at how alcohol use disorder changes after weight-loss surgery. Researchers want to understand the link between eating disorders, alcohol problems, and addiction treatment before and after surgery.
StrasbourgAges 18 years+ - NCT07148843RecruitingPhase 2/Phase 3
CBD for alcohol withdrawal and cravings
This study tests whether adding CBD (a cannabis compound that doesn't get you high) to usual care can help reduce alcohol withdrawal symptoms and cravings. It may offer a new way to support people trying to cut down or stop drinking.
Baltimore, MarylandAges 21–65 - NCT06789250Recruiting
Online therapy for mental health and alcohol use issues
This trial tests an internet-based cognitive behavioral therapy program designed for people who struggle with both mental health symptoms (like depression or anxiety) and problematic alcohol use. The goal is to see if this approach can help improve both issues at the same time, conveniently from home.
LinköpingAges 18 years+ - NCT04331704RecruitingPhase 4
Alcohol and sexual health program for men at risk of HIV
This study tests an alcohol- and sexual-health program to help reduce HIV risk in men who recently had condomless sex and drink heavily. It may help you by offering structured support around drinking and HIV prevention (PrEP).
Gainesville, FloridaAges 18–30
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 409 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.