Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 418 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07086014Recruiting
Brain response to methamphetamine cues in men
This study uses brain scans to see how men with methamphetamine use disorder react to images or reminders of the drug. It aims to understand cravings and brain activity, which could help improve treatments.
New York, New YorkAges 18–60 - NCT05703685RecruitingPhase 1
Imaging brain inflammation target in depression with PET
This Phase 1 study uses a PET brain scan tracer to see how a specific brain target (PDE4B) is involved in major depressive disorder (MDD). It’s mainly testing whether the imaging approach works and what it shows in people with depression who meet specific safety and medication rules.
Bethesda, MarylandAges 18–70 - NCT07136363Recruiting
RESTORE study: support for stimulant users leaving jail or prison
This trial tests a smartphone app (DynamiCare) to help people recovering from stimulant use (methamphetamine or cocaine) stay healthy after leaving jail or prison. It also focuses on those at risk for or living with HIV.
New Haven, ConnecticutAges 18 years+ - NCT06575751RecruitingPhase 2
Study of cannabidiol and cannabis concentrate users
This study looks at how cannabidiol (a compound in cannabis) affects people who regularly use strong cannabis concentrates like wax, shatter, or oil. It may help understand if using CBD can change how cannabis affects the body or help with cannabis use disorder.
Aurora, ColoradoAges 25–60 - NCT07091877Recruiting
Cocaine use and brain response study
This study looks at how cravings for cocaine change over time in people who have recently stopped using. Researchers will measure brain activity to understand this process better.
New York, New YorkAges 18–65 - NCT06430580RecruitingEarly Phase 1
Cannabinoids and stress response in heavy cannabis users
This early-phase study tests how cannabinoids affect your body's reaction to stress. If you use cannabis daily and have cannabis use disorder, you may be able to join to help researchers understand these effects better.
Tallahassee, FloridaAges 18–50 - NCT07050862Recruiting
Personalized brain stimulation to help veterans quit smoking
This study tests a personalized brain stimulation treatment to help veterans quit smoking. It uses magnetic pulses to target brain areas involved in addiction, which may reduce cravings and make it easier to stop.
Charleston, South CarolinaAges 18–70 - NCT07602270Recruiting
How a Ketogenic Diet Affects Alcohol in Your Body
This study tests whether eating a ketogenic diet (very low carb, high fat) changes how your body processes alcohol. Researchers will have you follow a special diet and then measure your body's response to controlled amounts of alcohol in a lab setting.
Philadelphia, PennsylvaniaAges 21–50 - NCT07064564RecruitingPhase 1
Study comparing naltrexone implants with monthly injection in healthy volunteers
This trial compares two forms of naltrexone (a medication used for alcohol and opioid dependence) in healthy volunteers. It tests how well the body processes and tolerates a low or high-dose implant versus the standard monthly injection.
Millcreek, UtahAges 18–65 - NCT07713251Recruiting
Computer skills training for teens seeking alcohol help
This study tests a computer-based program called Path180 to help teenagers ages 13-19 reduce their alcohol use. If you are already seeing a counselor or in treatment for alcohol or mental health, this program might add extra support.
Providence, Rhode IslandAges 13–19 - NCT03827460RecruitingPhase 1
Study tests how men and women respond to alcohol abstinence
This Phase 1 study looks at sex differences in how the body and brain respond when people stop drinking alcohol for a short time. You may be asked to complete questionnaires and provide blood samples to measure changes during the abstinence period.
Indianapolis, IndianaAges 21–35 - NCT04084860RecruitingPhase 2
Brief medicine trial to help reduce heavy alcohol drinking
This Phase 2 study tests a brief medication approach meant to reduce “problem drinking.” It may help people cut back or stop alcohol use by adjusting brain signaling related to drinking cravings and urges.
New York, New YorkAges 21–70 - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85 - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT04770025RecruitingPhase 2
Brain stimulation with therapy for risky alcohol use
This study tests whether a non-invasive brain stimulation device can make standard psychotherapy work better for people who drink in a risky way. It’s designed for community participants who are not already in alcohol-use treatment.
Albuquerque, New MexicoAges 21–60 - NCT04773691Recruiting
High-frequency brain stimulation to help cut alcohol use
This trial tests whether high-frequency rTMS (a non-surgical brain stimulation) can reduce how much alcohol you drink. It targets people with alcohol use disorder who are not fully stopping, and who want to cut down after a past relapse or failed withdrawal attempt.
DijonAges 18 years+ - NCT04929288Recruiting
Study how hormones affect alcohol risk in men and women
This study looks at how brain activity and hormone-related factors may help explain differences in alcohol risk between men and women. It may help researchers understand why alcohol use differs by sex and how risk develops.
Columbus, OhioAges 21–26 - NCT05033028RecruitingPhase 3
Using a smartphone to support opioid addiction recovery
This Phase 3 study tests whether using smartphones can help people with opioid-use disorder stick with treatment and recover more successfully. It focuses on people starting or already in treatment using methadone or buprenorphine, with support delivered through the study app or messages.
Piscataway, New JerseyAges 18–85 - NCT05062369Recruiting
Brain stimulation plus training to support alcohol abstinence
This study tests whether a combination of brain stimulation (tDCS) and cognitive training can help people with alcohol use disorder stay abstinent. You may be included if you are currently not drinking and can commit to the program timeline.
Minneapolis, MinnesotaAges 18–65 - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT05178069RecruitingPhase 2
Probiotic supplement study for alcohol use disorder and liver injury
This Phase 2 trial studies whether a probiotic (LGG) can improve health in people with alcohol use disorder and alcohol-related liver injury. It’s not an alcohol treatment study, so participants are mainly joining to see how the supplement affects the body and liver-related outcomes.
Louisville, KentuckyAges 21–65 - NCT05619185Recruiting
Online program to help couples reduce risky drinking
This study tests an adaptive (tailored) online program to help service members and their partners cut down risky alcohol use. It also focuses on whether couples can practice healthier communication and coping skills while feeling safe together.
Palo Alto, CaliforniaAges 18 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05766254Recruiting
Brain stimulation study for nicotine dependence and reward activity
This trial tests different targets for repetitive transcranial magnetic stimulation (rTMS)—a non-surgical brain stimulation—to change brain “reward” activity in people who are nicotine dependent. If you qualify, you may receive sessions of brain stimulation as the researchers look for the best brain target.
Newark, New JerseyAges 18–55
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 418 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.