Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06387290RecruitingPhase 3
Mindfulness and pain management for chronic pain on opioids
This study tests whether adding mindfulness training to standard pain management visits can help people with chronic pain who are taking long-term opioids. It aims to improve pain relief and reduce opioid-related risks.
La Jolla, CaliforniaAges 18 years+ - NCT06661031Enrolling by invitation
Cannabis use help for young adults via phone app
This study tests a new program that combines telehealth coaching and a smartphone app to help young adults who use cannabis a lot to cut back or quit. If you are a patient at certain Boston clinics and use cannabis on most days, this study might be a good fit for you.
Boston, MassachusettsAges 18–26 - NCT05576350Recruiting
Coaching to reduce risky drinking and HIV risk
This study tests an intervention (coaching/skills training) to help reduce risky alcohol use and reduce behaviors that increase HIV risk. It may help you if you drink in an at-risk way and may benefit from HIV prevention like PrEP.
New Haven, ConnecticutAges 18–35 - NCT07466784Recruiting
Opioid use registry for emergency patients
This study is for people who come to the emergency department because of an opioid overdose, withdrawal, or related problem. It will collect information about patients' experiences to help improve care and support for opioid use.
Vancouver, British ColumbiaAges Any age - NCT06214065Recruiting
Brain stimulation for social thinking in autism
This trial tests whether mild brain stimulation (TMS) over the temporoparietal junction can improve a social thinking skill called 'mentalizing' in adults with autism. You would have MRI scans, cognitive tasks, and several TMS sessions.
Hartford, ConnecticutAges 18–35 - NCT05365347Recruiting
Program to reduce risky alcohol use in early psychosis
This study tests an intervention aimed at helping people with early psychosis who also drink in a risky way. It may help reduce problematic drinking during a critical early period of illness.
Halifax, Nova ScotiaAges 16–35 - NCT05453513Recruiting
Study how depression and cannabis affect the brain in young adults with HIV
This study looks at brain activity to understand how depression and cannabis use may be linked in young adults living with HIV. It mainly involves questionnaires, mental health screening, and brain scans, which may help researchers better understand risk factors and brain “underpinnings.”
Miami, FloridaAges 18–59 - NCT04871048Recruiting
tDCS training to reduce cannabis use in people with schizophrenia
This trial tests whether a non-painful brain stimulation method (tDCS) can help people with schizophrenia who also have moderate-to-severe cannabis use disorder reduce or quit cannabis. It also involves MRI scanning to help study brain changes.
BronAges 18–60 - NCT07091292Recruiting
Exercise as a treatment for cannabis use
This study tests whether regular exercise can help young adults reduce or stop their cannabis use. It may be a good fit if you are 18-40, use cannabis as your main drug, and want to try an exercise-based approach.
Hong KongAges 18–40 - NCT05684094Recruiting
Study links sleep, stress, and brain reward in risky drinking
This study looks at how sleep timing and stress affect brain responses related to reward and stress in young adults who drink heavily. It may help researchers understand why some people take bigger alcohol risks and how sleep and stress could be part of safer treatment.
Eugene, OregonAges 18–24 - NCT05866107Recruiting
App and smart scale program for weight loss in bipolar or schizophrenia
This study tests whether using a health app and smart body-fat scales helps people who are overweight or obese lose weight. It is designed for adults with bipolar disorder or schizophrenia who are stable and can safely follow the weight-loss and activity plan.
Beijing, Beijing MunicipalityAges 18–60 - NCT04084860RecruitingPhase 2
Brief medicine trial to help reduce heavy alcohol drinking
This Phase 2 study tests a brief medication approach meant to reduce “problem drinking.” It may help people cut back or stop alcohol use by adjusting brain signaling related to drinking cravings and urges.
New York, New YorkAges 21–70 - NCT06189690Recruiting
Brain stimulation study for cocaine addiction
This trial tests whether a non-invasive brain stimulation technique called high-frequency repetitive transcranial magnetic stimulation (HF rTMS) can help reduce cocaine cravings and change brain chemistry. It may be a good option if you have cocaine use disorder and want to explore a new treatment that doesn't involve medication.
Mexico City, TlalpanAges 18–50 - NCT07812753Recruiting
Brain stimulation for smoking cessation
This study looks at how a non-invasive brain stimulation technique called TMS (which uses magnetic pulses to stimulate the brain) might affect the brain's reward system in people who smoke. The goal is to understand how to help people quit smoking more effectively.
Newark, New JerseyAges 18–60 - NCT07713251Recruiting
Computer skills training for teens seeking alcohol help
This study tests a computer-based program called Path180 to help teenagers ages 13-19 reduce their alcohol use. If you are already seeing a counselor or in treatment for alcohol or mental health, this program might add extra support.
Providence, Rhode IslandAges 13–19 - NCT06453109Recruiting
Focused ultrasound for chronic back pain with opioid use
This study tests whether focused ultrasound (a non-invasive treatment using sound waves) can help people with chronic back pain who also have opioid use disorder and anxiety. It aims to find a better way to manage pain without relying on opioids.
Washington D.C., District of ColumbiaAges 18–75 - NCT07624227RecruitingPhase 1/Phase 2
Cobenfy Maintenance Effects on Cocaine Use Disorder
This study tests whether a medication called Cobenfy can reduce cocaine's effects in people with cocaine use disorder. Researchers will monitor your health and test how the medication impacts your response to cocaine.
Lexington, KentuckyAges 18–60 - NCT07610746Recruiting
Brain Blood Flow in Newborns Exposed to Opioids Before Birth
This study looks at how opioid exposure during pregnancy affects blood flow and brain function in newborns. Researchers will compare babies exposed to opioids in the womb with babies who were not exposed, to better understand how prenatal opioid exposure affects the developing brain.
Indianapolis, IndianaAges Up to 1 day - NCT07602270Recruiting
How a Ketogenic Diet Affects Alcohol in Your Body
This study tests whether eating a ketogenic diet (very low carb, high fat) changes how your body processes alcohol. Researchers will have you follow a special diet and then measure your body's response to controlled amounts of alcohol in a lab setting.
Philadelphia, PennsylvaniaAges 21–50 - NCT07592195Recruiting
Breathing and aerobic exercise for men in drug recovery
This study tests whether breathing exercises and aerobic exercise (like walking or jogging) improve physical and mental health in men recovering from substance use. You'd attend supervised exercise sessions twice a week for 8 weeks and complete health questionnaires.
LuzhouAges 18–50 - NCT07561749Enrolling by invitation
Staying sober and inner peace in alcohol recovery
The study looks at how a person's mental, social, and spiritual life relates to a long period of staying sober. People who have been alcohol-free for at least a year may be able to help paint a clearer picture of what supports recovery.
Iași, IaşiAges 18–70 - NCT06125054RecruitingPhase 2
Ketamine and brain training for cocaine addiction
This trial tests whether a combination of ketamine (a medicine that may help the brain change) and neurofeedback training (a brain-exercise technique) can help people with cocaine addiction. The goal is to see if these treatments can improve brain flexibility and reduce cravings.
Zurich, Canton of ZurichAges 18–55 - NCT07532460Recruiting
Study of brain channels and memory in cocaine users
This research explores how certain brain chemicals (potassium channels) affect memory and thinking in people who use cocaine regularly. The study may help develop better treatments for cocaine use disorder and related thinking problems.
Zurich, Canton of ZurichAges 20–50 - NCT07457489Recruiting
Brain stimulation for opioid recovery
This study tests a non-invasive brain stimulation technique called TMS to see if it can reduce opioid cravings and help people who are already taking buprenorphine stay in recovery. TMS uses magnetic pulses to stimulate parts of the brain involved in addiction.
Brentwood, TennesseeAges 18–65
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 409 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.