Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 421 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06435494Enrolling by invitation
Using patient reports to improve shoulder care across clinics
This study tests whether asking patients about their shoulder symptoms using a phone or computer app can help doctors and therapists work together to improve care. It is for adults with shoulder pain that started without a sudden injury.
Gentofte Municipality, HellerupAges 18–120 - NCT03935646RecruitingPhase 2
Test of Adderall’s short-term effects in college students with ADHD
This study measures how stimulant medication (Adderall) affects college students with ADHD in the short term. It compares people with ADHD to students without ADHD to see what changes you may notice during the study.
Laramie, WyomingAges 18–29 - NCT07649278Recruiting
ENHANCE Project Toolkit for people who use drugs
This study tests a toolkit designed to help people who use drugs access harm reduction services (like overdose prevention supplies and support). Researchers want to hear from people with recent drug use and from peer mentors about what would make these services easier to use.
Madison, WisconsinAges 18 years+ - NCT05489068Recruiting
Motivational interviewing approach for people starting addiction treatment
This study compares two ways of having conversations when you begin outpatient addiction treatment. It tests whether a motivational interviewing style at intake improves your engagement and involvement in your care.
Albuquerque, New MexicoAges 18 years+ - NCT05570708Enrolling by invitation
Therapist training trial on how experience shapes therapy
This study looks at how therapists’ personal experience affects their attitude and skills during substance-assisted therapy training. It’s mainly for therapists-in-training, and may help improve how future training and therapy are delivered safely.
BaselAges 27 years+ - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT05598034Recruiting
Brain stimulation with tDCS for moderate depression
This study tests whether a noninvasive brain stimulation called tDCS can improve depression symptoms. It also uses MRI scans, aiming to understand how brain changes may relate to symptom improvement.
Los Angeles, CaliforniaAges 20–55 - NCT06273904Recruiting
Focused ultrasound to help manage anxiety
This trial tests whether focused ultrasound can help people with anxiety disorders better manage their symptoms. It involves brain stimulation and recording sessions to see how the treatment works.
Charleston, South CarolinaAges 18–65 - NCT06897670Recruiting
Brain blood flow patterns in mood and memory disorders
This study uses a headband with light sensors (fNIRS) to measure blood flow in the brain while you do thinking tasks. It aims to understand differences in brain activity for people with depression, bipolar disorder, or mild memory loss.
Rochester, MinnesotaAges 18 years+ - NCT05877885Recruiting
Digital treatment for low motivation in older adults with depression
This study tests a digital therapy to improve apathy (feeling unmotivated or “checked out”) in people age 60+ who have depression. It also uses brain imaging (MRI) and questionnaires to see whether the treatment helps brain function linked to motivation.
Orlando, FloridaAges 60 years+ - NCT06781905Recruiting
Brain effects of ALK/ROS1 lung cancer drugs and quality of life
This study looks at how certain targeted therapy drugs for ALK/ROS1-positive lung cancer may affect thinking, memory, mood, and mental health. It aims to build a special care and research path where patients and researchers work together to understand and manage these side effects.
BronAges 18 years+ - NCT07446114Recruiting
Brain-computer interface trial for ALS (Canada)
This trial tests a brain-computer interface (BCI) device that may help people with ALS or motor neuron disease regain some control over their environment. It involves implanting the device in a blood vessel in the brain.
Toronto, OntarioAges 18 years+ - NCT07533903Recruiting
Brain-Computer Interface for Arm Control in Paralysis
This trial tests a surgically implanted brain-computer interface (BCI) device designed to help people with severe arm paralysis—from conditions like ALS or stroke—regain some ability to control their arms. The device reads signals from your brain and translates them into arm movements, potentially helping you perform daily activities.
MelbourneAges 21 years+ - NCT06853665RecruitingPhase 4
Study of mixed amphetamine for autism and ADHD in teens
This trial tests if a mixed amphetamine medication helps teenagers with both autism and ADHD who still have significant symptoms, even if they are already on other treatments. It also includes typically developing teens as a comparison group.
Boston, MassachusettsAges 8–18 - NCT04956016Recruiting
Compare two rTMS treatments for moderate to severe depression
This study tests whether a classic type of brain stimulation (rTMS) works better or the same as a deeper version for depression that keeps coming back or is ongoing. You may be offered one of the two stimulation options to see which helps reduce depressive symptoms.
PoitiersAges 18 years+ - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT07083557Recruiting
Validation study for lab tests on hormones and metabolism
This study checks if lab tests used for hormone, heart, metabolism, and muscle disorders are accurate and reliable. You might be eligible if you are an adult with a body mass index between 16 and 60.
Columbia, MissouriAges 18–100 - NCT07533773Recruiting
Brain Activity Changes After Depression Treatment
This study measures how brain activity in specific regions changes after you receive electroconvulsive therapy (ECT) or magnetic seizure therapy (MST) for severe depression. Researchers use a non-invasive headband to monitor blood flow in your brain before and after treatment to better understand how these therapies work.
Hefei, AnhuiAges 12–65 - NCT06373016Recruiting
Ketone drink study for stable bipolar disorder
This study tests whether a ketone drink can change how the body uses energy in people with bipolar disorder. It may help understand new ways to manage the condition.
Belmont, MassachusettsAges 18–45 - NCT05929144Recruiting
MRI testing to improve brain scans in neurodegenerative diseases
This study aims to improve MRI scan settings used when studying brain diseases that affect memory and movement. You would be asked to undergo MRI scanning as a healthy volunteer to help optimize the imaging process.
CaenAges 18 years+ - NCT07263321Recruiting
Depression treatment choice in general practice
This study helps people with moderate depression decide between medication and therapy. Your doctor will work with you to pick the best option.
AalborgAges 18–65 - NCT06544226Recruiting
Using smart devices to track eating disorder recovery
This study tests whether smart devices can help monitor recovery in people with eating disorders. You will use a device to track health signs and attend weekly clinic visits.
LiverpoolAges 10 years+ - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT07469384Recruiting
Brain stimulation study for schizophrenia using tDCS
This study tests whether a mild form of brain stimulation called tDCS (transcranial direct current stimulation) can help improve symptoms of schizophrenia or schizoaffective disorder. tDCS uses small electrodes on the scalp to gently stimulate brain areas involved in vision and thinking.
Orangeburg, New YorkAges 18–55
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 421 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.