Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07226570Recruiting
Ibogaine brain mapping study for opioid use disorder
This study uses MRI and EEG scans to map how ibogaine affects the brain in people with opioid use disorder. You must already be scheduled to receive ibogaine treatment in Tijuana, Mexico, on your own, as the study does not cover treatment costs.
Irvine, CaliforniaAges 21–70 - NCT07219966RecruitingPhase 3
Study of Brenipatide for alcohol use disorder
This trial tests an injectable medicine called brenipatide to help people with moderate-to-severe alcohol use disorder reduce or stop drinking. It is for adults who are motivated to change their drinking habits.
Birmingham, AlabamaAges 18–75 - NCT07219953RecruitingPhase 3
Testing brenipatide for alcohol use disorder
This study tests an experimental medicine called brenipatide to help people reduce or stop drinking. It involves getting a daily injection and completing check-ins and questionnaires over several months.
Scottsdale, ArizonaAges 18–75 - NCT06105853Recruiting
Stress and brain activity in alcohol use disorder
This study looks at how people with alcohol use disorder respond to stress and what happens in the brain. You'll use a smartphone and may have an MRI scan to understand your stress responses.
Mannheim, Baden-WurttembergAges 18–65 - NCT07158853RecruitingPhase 1
Brain stimulation and training for opioid use disorder
This trial combines a gentle brain stimulation technique called tDCS with thinking exercises to see if it helps people with opioid use disorder who are already on medication. It aims to improve treatment outcomes
Minneapolis, MinnesotaAges 18 years+ - NCT05986578Recruiting
Brain stimulation for cocaine use disorder
This study tests whether brain stimulation can help people with cocaine use disorder. It is a research study that aims to identify brain targets for treatment with a non-invasive technique called transcranial magnetic stimulation (TMS).
Houston, TexasAges 18–65 - NCT07112105Recruiting
Magnetic brain stimulation for stimulant use disorder in Veterans
This study tests whether magnetic brain stimulation (called TMS) can help treat severe stimulant use disorder in Veterans. If you qualify, you would receive TMS sessions and be monitored to see if it reduces your stimulant use.
Palo Alto, CaliforniaAges 18–65 - NCT07044466Recruiting
Social functioning study for people in treatment for opioid use
This study looks at how people recovering from opioid use disorder get along with a close friend or family member (called a CSO). It may help improve social support during early treatment.
Charleston, South CarolinaAges 18 years+ - NCT07029529RecruitingPhase 2
Apremilast for alcohol use disorder
This study tests whether a drug called apremilast can help people who drink heavily reduce their alcohol use. You will take the medication daily for several weeks and attend study visits to track your progress.
New Haven, ConnecticutAges 21–65 - NCT06994338RecruitingPhase 2
Tirzepatide for alcohol use disorder
This study tests whether a medication called tirzepatide (a once-weekly injection) can help people reduce their alcohol consumption. It is for people who drink heavily, have a high BMI, and are actively seeking help to drink less.
Los Angeles, CaliforniaAges 21–65 - NCT06985927Recruiting
Self-Concept and Memory in Alcohol Use Disorder
This study looks at how people with alcohol use disorder remember their past and see themselves. Researchers will ask about your memories and self-image to understand the link between alcohol and thinking patterns.
ReimsAges 24 years+ - NCT06866379Recruiting
Brain study on alcohol use disorder: septal nuclei
This study uses brain scans (fMRI) to look at a small area deep in the brain called the septal nuclei, which may play a role in alcohol use disorder. It aims to understand how the brain's structure and activity relate to heavy drinking, which could lead to better treatments.
FrederiksbergAges 30–65 - NCT06949423Recruiting
Deep TMS for alcohol use disorder
This study tests whether deep transcranial magnetic stimulation (dTMS) can change brain activity related to alcohol use. It is for people who have moderate to severe alcohol use disorder and are willing to attend clinic visits.
Palo Alto, CaliforniaAges 18–75 - NCT06943859RecruitingPhase 2
Ketamine for opioid use disorder
This study tests whether ketamine, when added to methadone treatment, helps reduce opioid use and cravings. It is for adults with opioid use disorder who are already in a methadone program and have had recent cravings or illicit use. The trial involves multiple visits and follow-up assessments.
Baltimore, MarylandAges 18–65 - NCT06790576RecruitingPhase 1
Optimizing TMS for stimulant use disorder
This test uses a safe, non-invasive brain stimulation method called TMS (transcranial magnetic stimulation) to see if it can help people with stimulant use disorder reduce their cravings and stay sober. You would need to be in an addiction treatment program and have been clean for at least 2 weeks to join.
Minneapolis, MinnesotaAges 18 years+ - NCT06706349Recruiting
Exercise to improve sleep in alcohol use disorder
This study tests whether a personalized exercise program can improve sleep quality in people with alcohol use disorder. You would work with a physical activity coach over several weeks, and your sleep and health would be monitored closely.
BesançonAges 18–65 - NCT06415721Recruiting
TMS guided by brain scans for alcohol use disorder
This study uses a brain stimulation technique called TMS combined with MRI scans to treat alcohol use disorder. It aims to see if targeting specific brain connections can help reduce drinking.
Palo Alto, CaliforniaAges 25–75 - NCT06660381RecruitingPhase 1
Psilocybin therapy for cannabis use disorder
This study tests if psilocybin (a substance that can change how you think and feel) can help people reduce or stop using cannabis. You will receive support and be monitored closely throughout the trial.
Baltimore, MarylandAges 18 years+ - NCT06643988Recruiting
Memory and thinking study for opioid use disorder
This study looks at how people with opioid use disorder remember personal events. You'll do tasks on a cellphone and at home while taking medication for opioid use disorder.
Philadelphia, PennsylvaniaAges 18–60 - NCT06620276Recruiting
Ketamine and therapy for alcohol use disorder and depression
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
Montreal, QuebecAges 18–70 - NCT06578429Recruiting
Deep TMS for methamphetamine use disorder
This study uses a type of brain stimulation called deep TMS to see if it can help people with methamphetamine use disorder reduce their cravings and use. You would receive daily magnetic pulses to specific brain areas over several weeks.
Palo Alto, CaliforniaAges 25–75 - NCT06559995RecruitingPhase 2/Phase 3
Ketone drink for alcohol withdrawal
This study tests whether a special ketone drink can ease alcohol withdrawal and help your brain heal. If you have been drinking heavily for at least 3 years and are having withdrawal symptoms now, this might be an option for you.
Philadelphia, PennsylvaniaAges 18–65 - NCT06444256RecruitingPhase 2
Testing a sleep medication for people with stimulant use
This trial tests whether a medication that blocks a brain chemical involved in wakefulness can help people with stimulant use disorder sleep better. If you use cocaine or methamphetamine and have trouble sleeping, this study may be an option.
Houston, TexasAges 18–65 - NCT06474026Recruiting
Focused Ultrasound for Stimulant Use Disorder
This trial tests a non-invasive brain treatment called focused ultrasound for people with stimulant use disorder (like methamphetamine or cocaine). It aims to help reduce cravings and improve recovery by gently stimulating a brain area involved in addiction.
Seoul, SeoulAges 19–60
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 409 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.