Clinical trials
Substance Use Risk clinical trials
Below are recruiting substance use risk clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07734623Recruiting
Ultrasound treatment for severe opioid or amphetamine use disorder
This trial tests a low-intensity focused ultrasound treatment for people with severe opioid or amphetamine use disorder. The ultrasound targets a part of the brain linked to addiction, and the goal is to see if it is safe and helpful.
TaipeiAges 20–50 - NCT06889831Recruiting
Paths to sexual health and recovery for women in the justice system
This study tests a program to help women with substance use and unmet contraception needs who have been involved with the criminal legal system in the past year. The goal is to see if the program supports both recovery and family planning choices.
Teaneck, New JerseyAges 18–44 - NCT05665179Recruiting
Community program for people receiving addiction treatment
This trial is focused on people who are currently getting treatment for substance use disorder. It aims to test community partnership approaches that reduce barriers and improve support during recovery.
Ann Arbor, MichiganAges 18 years+ - NCT06679062RecruitingPhase 2
Suvorexant for alcohol use disorder and PTSD
This study tests whether the sleep medication suvorexant can help people with both alcohol use disorder and PTSD. If you're struggling with drinking, PTSD symptoms, and poor sleep, this trial may offer a new treatment option.
Los Angeles, CaliforniaAges 21–65 - NCT05964010Recruiting
Parent-and-teen program for teen health visits
This trial offers a structured support program for teenagers and their primary caregiver during a primary care visit. It may help by testing an approach that connects youth and families with resources and support starting at the clinic visit.
New York, New YorkAges 12–17 - NCT07741825Recruiting
Mindfulness training to prevent relapse for peer support workers
This study tests a mindfulness-based program to help people who work as peer support specialists in substance use recovery reduce their risk of relapse. It may help you manage cravings and stay healthy in your role.
Austin, TexasAges 18–100 - NCT06810973Enrolling by invitation
HIV and Substance Use Support for People Leaving Jail
This study helps people with HIV or high risk of HIV who have had substance use problems and are in jail or recently released. It tests a program called SUCCESS-E to support health and reduce drug use.
Atlanta, GeorgiaAges 18 years+ - NCT05327504Recruiting
Writing therapy for PTSD and substance use in veterans
This study tests a structured “written exposure” therapy to help veterans with PTSD who also have a substance use disorder (SUD). It may help reduce PTSD symptoms while also supporting safer, more stable recovery.
West Haven, ConnecticutAges 18 years+ - NCT05562557Recruiting
Fatherhood program to improve outcomes and support families
This study partners with fathers to help improve family outcomes, especially when there are worries about substance use in the household. You may be able to join if you are a father caregiver and your family has an identified risk for substance use, and you speak English or Spanish.
The Bronx, New YorkAges 18 years+ - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT06216600Recruiting
Women's strength and resilience program for HIV and substance use
This study tests a program for women living with HIV who also struggle with substance use or heavy drinking. It combines exercise and support to help build strength and resilience. You may qualify if you've missed some HIV medications, have a detectable viral load, and have experienced violence.
San Diego, CaliforniaAges 18 years+ - NCT06479980Recruiting
Single session narrative therapy study
This study tests a single session of narrative therapy to help patients at the clinic process personal stories and improve well-being. It is for adults who can complete surveys in English.
Seattle, WashingtonAges 18 years+ - NCT06837311Recruiting
Smoking cessation after stroke via smartphone monitoring
This study tests a smartphone-based program that helps people who recently had a stroke quit smoking. It uses digital monitoring and support as part of your regular post-stroke follow-up to lower the risk of another stroke.
BordeauxAges 18–80 - NCT07146633Recruiting
Testing an EMDR app for PTSD and substance use
This study tests an app that uses EMDR therapy to help people with both PTSD and substance use problems. EMDR is a type of therapy that uses eye movements or taps to help process traumatic memories. You would use the app at home and avoid starting other new therapies during the study.
Toronto, OntarioAges 18 years+ - NCT07230847Recruiting
Healing of drug-coated vs. standard stents in high-bleeding-risk patients
This trial compares two types of stents (a drug-coated stent and a standard drug-eluting stent) in people with acute coronary syndrome who also have a high risk of bleeding. It uses a special camera to look at how the artery heals one month after the stent is placed.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT07130500Enrolling by invitation
Rewards for sticking with long-acting injections
This study tests whether offering small rewards (like gift cards) can help people stick with a long-acting injection of their medication. It's for people with serious mental health conditions who have had a recent hospital stay or are at high risk of one.
Pittsburgh, PennsylvaniaAges 18–65 - NCT03506867Enrolling by invitation
Test program to help recent smokers in Ottawa or Toronto
This trial offers a health program for people age 16+ who smoked recently and live in Ottawa or Toronto. It aims to help with quitting and follow-up over one year, especially for people facing financial hardship or housing instability.
Ottawa, OntarioAges 16 years+ - NCT03249428Enrolling by invitation
Cytisine vs nicotine patches for quitting smoking
This study compares cytisine (an aid to reduce cravings) with nicotine replacement therapy (like patches or gum) to help people quit tobacco/nicotine. It also looks at whether the two options work for people facing higher barriers like low income or housing insecurity.
Ottawa, OntarioAges 18 years+ - NCT06788587RecruitingPhase 2
Long-term stimulant for methamphetamine recovery
This study tests whether a high dose of a stimulant medication (lisdexamfetamine, an ADHD medicine) taken over many weeks can help people who have already completed a methamphetamine treatment program to stay off meth, reduce use, or avoid relapse.
Montreal, QuebecAges 18–55 - NCT04164940Recruiting
Tracking how hospital care affects alcohol risk in older adults
This study looks at how adults aged 21+ change over time after being admitted to the hospital for alcohol-related problems. It may help researchers understand which hospital approaches work best for reducing future alcohol-related harm—especially for people who have not had alcohol or drug use disorders before.
StavangerAges 21 years+ - NCT05570708Enrolling by invitation
Therapist training trial on how experience shapes therapy
This study looks at how therapists’ personal experience affects their attitude and skills during substance-assisted therapy training. It’s mainly for therapists-in-training, and may help improve how future training and therapy are delivered safely.
BaselAges 27 years+ - NCT07458425Recruiting
Lung cancer screening study using AI
This study tests how well an AI tool can predict lung cancer risk, based on your health information. It looks at how patients feel about this approach to screening, with the goal of making screening more personal and effective.
Chicago, IllinoisAges 50–80 - NCT06444360Recruiting
Program to reduce stimulant use and risky sex in young adults
This study tests a program to help sexually active young adults reduce stimulant use and risky sexual behavior. It involves online coaching sessions, and you can join from home if you have a private space and video chat access.
Los Angeles, CaliforniaAges 16–24
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Common questions
- Are there clinical trials for substance use risk?
- Yes. Clin2 currently lists 55 recruiting substance use risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.